ArticleEcology letters2015
Effects of host heterogeneity on pathogen diversity and evolution.
Article in Ecology letters, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
33 citing papers in PubMed, 63 citations in OpenAlex.
- Playing it safe at early life stages: Balancing energy allocations to maximize fitness under seasonal pathogen dynamics.The Journal of animal ecology · 2026Article
- Infected host competence overshadows heterogeneity in susceptibility in shaping experimental epizootics.Ecology · 2026Article
- Prior pathogen exposure augments inter-individual heterogeneity in antibody levels and reinfection loads in a songbird-pathogen system.Scientific reports · 2026Article
- Host Prior Exposure Augments Gene Expression Heterogeneity of Both Host and Pathogen During In Vivo Infection.Molecular ecology · 2026Article
- Synthesizing selection mosaic theory and host-pathogen theory to explain large-scale pathogen coexistence.Nature communications · 2025Article
- Infected host competence overshadows heterogeneity in susceptibility in shaping experimental epizootics.bioRxiv : the preprint server for biology · 2025Article
- Host prior exposure augments heterogeneity in gene expression in both host and pathogen duringbioRxiv : the preprint server for biology · 2025Article
- Reinfection with a Bacterial Pathogen Augments Heterogeneity in Host Disease Responses.Research square · 2025Article
- Characterization of Ravn virus viral shedding dynamics in experimentally infected Egyptian rousette bats (Journal of virology · 2025Article
- Systematic shifts in the variation among host individuals must be considered in climate-disease theory.Proceedings. Biological sciences · 2025Article
- Baculovirus Genetic Diversity and Population Structure.Viruses · 2025Review
- Weak-form inference for hybrid dynamical systems in ecology.Journal of the Royal Society, Interface · 2024Article
- Prior exposure to pathogens augments host heterogeneity in susceptibility and has key epidemiological consequences.PLoS pathogens · 2024Article
- Prior exposure to pathogens augments host heterogeneity in susceptibility and has key epidemiological consequences.bioRxiv : the preprint server for biology · 2024Article
- Article
- Spatiotemporal-social association predicts immunological similarity in rewilded mice.Science advances · 2023Article
- Conflicting Evidence between Clinical Perception and Molecular Epidemiology: The Case of Fowl Adenovirus D.Animals : an open access journal from MDPI · 2023Article
- Social association predicts immunological similarity in rewilded mice.bioRxiv : the preprint server for biology · 2023Article
- Article
- Metagenomics show high spatiotemporal virus diversity and ecological compartmentalisation: Virus infections of melon,Virus evolution · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 4 institutions in 2 countries.
Funding
Abstract
Phenotypic variation is common in most pathogens, yet the mechanisms that maintain this diversity are still poorly understood. We asked whether continuous host variation in susceptibility helps maintain phenotypic variation, using experiments conducted with a baculovirus that infects gypsy moth (Lymantria dispar) larvae. We found that an empirically observed tradeoff between mean transmission rate and variation in transmission, which results from host heterogeneity, promotes long-term coexistence of two pathogen types in simulations of a population model. This tradeoff introduces an alternative strategy for the pathogen: a low-transmission, low-variability type can coexist with the high-transmission type favoured by classical non-heterogeneity models. In addition, this tradeoff can help explain the extensive phenotypic variation we observed in field-collected pathogen isolates, in traits affecting virus fitness including transmission and environmental persistence. Similar heterogeneity tradeoffs might be a general mechanism promoting phenotypic variation in any pathogen for which hosts vary continuously in susceptibility.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.