Evidence map›Paper›PMID 26365334›Full record

ArticleJournal of neuroscience methods2015

So you think you can jump? A novel long jump assessment to detect deficits in stroked mice.

Nitish Mittal, Jie Pan, Julie Palmateer, Lianna Martin, Arushi Pandya, Sungita Kumar, Adaora Ofomata, Patricia D Hurn, Timothy Schallert

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neuroscience methods, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Nitish MittalCollege of Pharmacy, University of Texas at Austin, Austin, TX, United States. Electronic address: mittal.n@utexas.edu.
Jie PanNanjing University Medical School, Nanjing, PR China; Department of Neuroscience, University of Texas at Austin, Austin, TX, United States.
Julie PalmateerDepartment of Neuroscience, University of Texas at Austin, Austin, TX, United States.
Lianna MartinDepartment of Psychology, University of Texas at Austin, Austin, TX, United States.
Arushi PandyaDepartment of Psychology, University of Texas at Austin, Austin, TX, United States.
Sungita KumarDepartment of Psychology, University of Texas at Austin, Austin, TX, United States.
Adaora OfomataDepartment of Psychology, University of Texas at Austin, Austin, TX, United States.
Patricia D HurnDepartment of Neuroscience, University of Texas at Austin, Austin, TX, United States; University of Texas System, Austin, TX, United States.
Timothy SchallertDepartment of Psychology, University of Texas at Austin, Austin, TX, United States.
The University of Texas at Austin · USAustin College · USNanjing Medical University · CN

Funding

PH-MEDIATED MECHANISMS OF INJURY IN CEREBRAL ISCHEMIAR01NR003521 · NINR · UNIVERSITY OF TEXAS AT AUSTIN · PI HURN, PATRICIA D. · 1994 to 2013
$4.5M
Mechanism of Vascular Dysfunction after Stroke in Postmenopausal FemaleR01NS070837 · NINDS · OREGON HEALTH & SCIENCE UNIVERSITY · PI ALKAYED, NABIL J · 2011 to 2015
$1.7M
NINDS NIH HHS R01NS070837NINR NIH HHS R01 NR003521
6 · The paper itself

Abstract

backgroundStroke survivors suffer from persistent disability, as well as severe sensorimotor and cognitive deficits. The preclinical assessment of such deficits is important for the development of novel interventions and therapeutics. NEW

methodThe aim of this study was to develop a quantitative behavioral measure of hindlimb functionality in rodents, which could be used to assess deficits after a neural injury, such as stroke. Here we introduce a test to measure long jump behavior in mice.

resultsUsing this test we first showed that while male and female mice exhibited no differences in jump success rate, the female mice showed lower baseline jumping latencies. Next we demonstrated that the induction of a cerebral stroke via middle cerebral artery occlusion (MCAO) for 45min did not affect the jump success rate in either group; however, it did significantly increase jump latencies in both male and female mice. Finally, we used therapeutic interventions to explore mechanisms that may be involved in producing this increase in jump latency by administering the anti-depressant fluoxetine prior to the long jump assay, and also tested for potential changes in anxiety levels after stroke. COMPARISON WITH EXISTING

methodsOther methods to assess hindlimb functionality are not specific, because they measure behaviors that rely not only on hindlimbs, but also on forelimbs and tail.

conclusionsThis study introduces a novel assay that can be used to measure a stroke induced behavioral deficit with great sensitivity, and raises interesting questions about potential mechanisms regulating this effect.

Indexed as

Disease Models, AnimalMotor ActivityAnimalsAnxietyFemaleFluoxetineHindlimbInfarction, Middle Cerebral ArteryMaleMice, Inbred C57BLNeurologic ExaminationSelective Serotonin Reuptake InhibitorsSex CharacteristicsStrokeTime FactorsTreatment OutcomeFluoxetineSelective Serotonin Reuptake InhibitorsAnxietyBehaviorDepressionMCAOStroke

Identifiers

PMID26365334
PMCPMC4651752
OpenAlexW1853466621

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.