ArticleJournal of neuroscience methods2016
Custom fit 3D-printed brain holders for comparison of histology with MRI in marmosets.
Article in Journal of neuroscience methods, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 27 citations in OpenAlex.
- A pipeline to characterize spinal cord pathology in neurological disorders combining magnetic resonance microscopy and histopathology.Communications medicine · 2026Article
- Considerations and recommendations from the ISMRM Diffusion Study Group for preclinical diffusion MRI: Part 3-Ex vivo imaging: Data processing, comparisons with microscopy, and tractography.Magnetic resonance in medicine · 2025Review
- Combination of high resolution MRI with 3D-printed needle guides for ex vivo myocardial biopsies.Scientific reports · 2024Article
- A technology platform for standardized cryoprotection and freezing of large-volume brain tissues for high-resolution histology.Frontiers in neuroanatomy · 2023Article
- The BrainboxBrain communications · 2023Article
- Letrozole treatment alters hippocampal gene expression in common marmosets (Callithrix jacchus).Hormones and behavior · 2023Article
- Ultrahigh-resolution MRI Reveals Extensive Cortical Demyelination in a Nonhuman Primate Model of Multiple Sclerosis.Cerebral cortex (New York, N.Y. : 1991) · 2021Article
- Magnetic Resonance Imaging of Marmoset Monkeys.ILAR journal · 2020Review
- A multimodal computational pipeline for 3D histology of the human brain.Scientific reports · 2020Article
- The spectrum of spinal cord lesions in a primate model of multiple sclerosis.Multiple sclerosis (Houndmills, Basingstoke, England) · 2020Article
- Potential role of iron in repair of inflammatory demyelinating lesions.The Journal of clinical investigation · 2019Article
- The "central vein sign" in inflammatory demyelination: The role of fibrillar collagen type I.Annals of neurology · 2019Article
- MR Imaging-Histology Correlation by Tailored 3D-Printed Slicer in Oncological Assessment.Contrast media & molecular imaging · 2019Review
- A Tangible Educative 3D Printed Atlas of the Rat Brain.Materials (Basel, Switzerland) · 2018Article
- Spatiotemporal distribution of fibrinogen in marmoset and human inflammatory demyelination.Brain : a journal of neurology · 2018Article
- A digital 3D atlas of the marmoset brain based on multi-modal MRI.NeuroImage · 2018Article
- Human and nonhuman primate meninges harbor lymphatic vessels that can be visualized noninvasively by MRI.eLife · 2017Article
- Utilizing 3D Printing Technology to Merge MRI with Histology: A Protocol for Brain Sectioning.Journal of visualized experiments : JoVE · 2016Article
- Towards a comprehensive atlas of cortical connections in a primate brain: Mapping tracer injection studies of the common marmoset into a reference digital template.The Journal of comparative neurology · 2016Article
- Advanced MRI and staging of multiple sclerosis lesions.Nature reviews. Neurology · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
backgroundMRI has the advantage of sampling large areas of tissue and locating areas of interest in 3D space in both living and ex vivo systems, whereas histology has the ability to examine thin slices of ex vivo tissue with high detail and specificity. Although both are valuable tools, it is currently difficult to make high-precision comparisons between MRI and histology due to large differences inherent to the techniques. A method combining the advantages would be an asset to understanding the pathological correlates of MRI. NEW
method3D-printed brain holders were used to maintain marmoset brains in the same orientation during acquisition of ex vivo MRI and pathologic cutting of the tissue.
resultsThe results of maintaining this same orientation show that sub-millimeter, discrete neuropathological features in marmoset brain consistently share size, shape, and location between histology and ex vivo MRI, which facilitates comparison with serial imaging acquired in vivo. COMPARISON WITH EXISTING
methodsExisting methods use computational approaches sensitive to data input in order to warp histologic images to match large-scale features on MRI, but the new method requires no warping of images, due to a preregistration accomplished in the technique, and is insensitive to data formatting and artifacts in both MRI and histology.
conclusionsThe simple method of using 3D-printed brain holders to match brain orientation during pathologic sectioning and MRI acquisition enables rapid and precise comparison of small features seen on MRI to their underlying histology.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.