Evidence map›Paper›PMID 26365021›Full record

ArticleJournal of clinical neurology (Seoul, Korea)2016

Treatment of Alzheimer's Disease with Repetitive Transcranial Magnetic Stimulation Combined with Cognitive Training: A Prospective, Randomized, Double-Blind, Placebo-Controlled Study.

Juyoun Lee, Byong Hee Choi, Eungseok Oh, Eun Hee Sohn, Ae Young Lee

2 registry-linked trialsOpen access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical neurology (Seoul, Korea), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 81 papers, 21 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
81citing papers in PubMed, 21 pooled it
6.9field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04482179 phase1completednot on this mapstarted 2020, after this paper: background citation

A Phase II, Randomized, Blinded Study of Transcranial Magnetic Stimulation and Constraint Induced Language Therapy for the Treatment of Chronic Aphasia - Alzheimer Disease Sub-study

TypeinterventionalSponsorUniversity of PennsylvaniaRan2020 to 2024Enrolled23ConditionsAlzheimer DiseaseArmsActive TMS, CILT, Sham TMS
NCT04866979 naunknown statusnot on this mapstarted 2021, after this paper: background citation

StimoLaMente - La Stimolazione Cerebrale Non Invasiva Applicata Alla Riabilitazione Della Malattia di Alzheimer/ StimoLaMente - Applying Non-invasive Brain Stimulation in Alzheimer's Rehabilitation

TypeinterventionalSponsorUniversità degli Studi di TrentoRan2021 to 2024Enrolled200ConditionsAlzheimer Disease, Mild Cognitive ImpairmentArmsExperimental: Continuous TBS (cTBS), Intermittent TBS (iTBS), Cognitive training (CT)., Sham Stimulation (shamTBS)
3 · Its place in the literature

Who cites it

81 citing papers in PubMed, 21 syntheses or guidelines pooled it, 163 citations in OpenAlex.

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  16. The role of noninvasive brain stimulation for behavioral and psychological symptoms of dementia: a systematic review and meta-analysis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2020
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  20. Cognitive training for people with mild to moderate dementia.The Cochrane database of systematic reviews · 2019
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21 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Juyoun LeeDepartment of Neurology, Cognitive Neuroscience Section, Chungnam National University Hospital, Daejeon, Korea.
Byong Hee ChoiCognitive Neuroscience Section, Chungnam National University Hospital, Daejeon, Korea.
Eungseok OhDepartment of Neurology, Cognitive Neuroscience Section, Chungnam National University Hospital, Daejeon, Korea.
Eun Hee SohnDepartment of Neurology, Cognitive Neuroscience Section, Chungnam National University Hospital, Daejeon, Korea.
Ae Young LeeDepartment of Neurology, Cognitive Neuroscience Section, Chungnam National University Hospital, Daejeon, Korea.
Chungnam National University Hospital · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

background and purposeRepetitive transcranial magnetic stimulation (rTMS) has been examined as a potential treatment for many neurological disorders. High-frequency rTMS in particular improves cognitive functions such as verbal fluency and memory. This study explored the effect of rTMS combined with cognitive training (rTMS-COG) on patients with Alzheimer's disease (AD).

methodsA prospective, randomized, double-blind, placebo-controlled study was performed with 27 AD patients (18 and 8 in the treatment and sham groups, respectively, and 1 drop-out). The participants were categorized into mild [Mini-Mental State Examination (MMSE) score=21-26] and moderate (MMSE score=18-20) AD groups. The rTMS protocols were configured for six cortical areas (both dorsolateral prefrontal and parietal somatosensory associated cortices and Broca's and Wernicke's areas; 10 Hz, 90-110% intensity, and 5 days/week for 6 weeks). Neuropsychological assessments were performed using the AD Assessment Scale-cognitive subscale (ADAS-cog), Clinical Global Impression of Change (CGIC), and MMSE before, immediately after, and 6 weeks after the end of rTMS-COG treatment.

resultsData from 26 AD patients were analyzed in this study. There was no significant interactive effect of time between the groups. The ADAS-cog score in the treatment group was significantly improved compared to the sham group (4.28 and 5.39 in the treatment group vs. 1.75 and 2.88 in the sham group at immediately and 6 weeks after treatment, respectively). The MMSE and CGIC scores were also improved in the treatment group. Based on subgroup analysis, the effect of rTMS-COG was superior for the mild group compared to the total patients, especially in the domains of memory and language.

conclusionsThe present results suggest that rTMS-COG represents a useful adjuvant therapy with cholinesterase inhibitors, particularly during the mild stage of AD. The effect of rTMS-COG was remarkable in the memory and language domains, which are severely affected by AD.

Indexed as

Alzheimer's diseasecognitive therapyrepetitive transcranial magnetic stimulation

Identifiers

PMID26365021
PMCPMC4712287
OpenAlexW2191791247

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.