ArticleMedical science monitor : international medical journal of experimental and clinical research2015
Relationship Between Hyperuricemia and Cardiovascular Disease Risk Factors in a Chinese Population: A Cross-Sectional Study.
Article in Medical science monitor : international medical journal of experimental and clinical research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 32 citations in OpenAlex.
- Benefits of uric acid-lowering medication after bariatric surgery in patients with gout.BMC surgery · 2024Article
- Effects of uric acid on ischemic diseases, stratified by lipid levels: a drug-target, nonlinear Mendelian randomization study.Scientific reports · 2024Article
- [Screening, domestication and identification of intestinal uric acid degrading bacteria in low uric acid population].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2022Article
- Prevalence and Clinical Predictors of Hyperuricemia in Chinese Bariatric Surgery Patients.Obesity surgery · 2022Article
- The dose-response relationship of serum uric acid with Dyslipidaemia and its components: a cross-sectional study of a Chinese multi-ethnic cohort.Lipids in health and disease · 2022Article
- The role of obesity, type 2 diabetes, and metabolic factors in gout: A Mendelian randomization study.Frontiers in endocrinology · 2022Article
- White blood cell count and the incidence of hyperuricemia: insights from a community-based study.Frontiers of medicine · 2019Article
- Uric acid level changes after bariatric surgery in obese subjects with type 2 diabetes mellitus.Annals of translational medicine · 2019Article
- Hypertriglyceridemia and hyperuricemia: a retrospective study of urban residents.Lipids in health and disease · 2019Article
- Prevalence of hyperuricemia and its related risk factors among preschool children from China.Scientific reports · 2017Article
- Association Between Alcohol Consumption and Metabolic Syndrome in a Community-Based Cohort of Korean Adults.Medical science monitor : international medical journal of experimental and clinical research · 2017Article
- Observational
- Gypenosides Inhibits Xanthine Oxidoreductase and Ameliorates Urate Excretion in Hyperuricemic Rats Induced by High Cholesterol and High Fat Food (Lipid Emulsion).Medical science monitor : international medical journal of experimental and clinical research · 2017Article
- The Association Between Hyperuricemia and Hematological Indicators in a Chinese Adult Population.Medicine · 2016Observational
- Analysis of the effect of glutamyltransferase on hyperlipidemia based on decision tree.Digital healthArticle
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Authors and funding
5 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTo study the relationship between hyperuricemia and cardiovascular diseases (CVDs) risk factors in a Chinese population. MATERIAL AND
methodsData analyzed in this study were from the Chinese Hyperuricemia and Gout Database. Indicators of serum uric acid (SUA) level, height, weight, systolic blood pressure (SBP), diastolic blood pressure (DBP), smoking status, alcohol consumption, blood glucose, cholesterol, and triglycerides were measured. T test, one-way analysis of variance, Pearson's correlation, multivariate linear regression, and multivariate logistic regression were used.
resultsCompared with normouricemic men, hyperuricemic men had greater height (P<0.01), weight (P<0.001), body mass index (BMI) (P<0.001), SBP (P<0.01), DBP (P<0.001), cholesterol (P<0.01), and triglyceride (P<0.001). Compared with normouricemic women, hyperuricemic women were older (P<0.01) and had greater weight (P<0.05), BMI (P<0.01), SBP (P<0.01), DBP (P<0.05), glucose (P<0.05), and triglyceride (P<0.001). In men, an increase of 1 mg/dL in SUA was associated with a 0.279 kg/m2 increase in BMI (P<0.001), a 2.438 mg/dL increase in cholesterol (P<0.05), a 10.358 mg/dL increase in triglyceride (P<0.001), and a 3.1 mg/dL decrease in glucose (P<0.01). In women, an increase of 1 mg/dL SUA was associated with a 0.168 kg/m2 increase in BMI (P<0.01) and a 3.708 mg/dL increase in triglyceride (P<0.01). After adjustment, SUA was strongly associated with obesity and hyperlipidemia in both sexes.
conclusionsElevated serum uric acid concentration was strongly associated with obesity and hyperlipidemia in both men and women. These results indicated that, among hyperuricemia patients, we should pay more attention to the possibility of cardiovascular complications. These results might provide a novel target or a possible new treatment for cardiovascular diseases by lowering the level of serum uric acid.
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