Evidence map›Paper›PMID 26364887›Full record

ReviewRadiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology2015

Modulation of therapeutic sensitivity by human papillomavirus.

Adam D Swick, Anirban Chatterjee, Anna-Maria A De Costa, Randall J Kimple

Open access · bronzeAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.8field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 19 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Adam D SwickDepartment of Human Oncology, School of Medicine and Public Health, University of Wisconsin, Madison, USA.
Anirban ChatterjeeDepartment of Human Oncology, School of Medicine and Public Health, University of Wisconsin, Madison, USA.
Anna-Maria A De CostaDepartment of Human Oncology, School of Medicine and Public Health, University of Wisconsin, Madison, USA.
Randall J KimpleDepartment of Human Oncology, School of Medicine and Public Health, University of Wisconsin, Madison, USA; University of Wisconsin Carbone Comprehensive Cancer Center, School of Medicine and Public Health, University of Wisconsin, Madison, USA. Electronic address: rkimple@humonc.wisc.edu.
University of Wisconsin–Madison · USUniversity of Wisconsin Carbone Cancer Center · US

Funding

Head and Neck squamous cell carcinoma radiation response modulation by HPVR00CA160639 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI KIMPLE, RANDALL J. · 2013 to 2015
$725k
Head and Neck squamous cell carcinoma radiation response modulation by HPVK99CA160639 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI KIMPLE, RANDALL J. · 2011 to 2012
$298k
NCI NIH HHS CA160639NCI NIH HHS K99 CA160639NCI NIH HHS R00 CA160639
6 · The paper itself

Abstract

Human papillomaviruses (HPVs) are small double-stranded DNA viruses that pose significant public health concerns as the causative agent of approximately 5% of worldwide cancers. The HPV oncogenes E6 and E7 play key roles in carcinogenesis. In the last 15years there has been a significant increase in the incidence of HPV-related head and neck cancers arising primarily in the oropharynx. Patients with HPV-positive head and neck cancers (HNCs) have a significantly improved prognosis compared to those with HPV-negative disease. In this review we will discuss data suggesting how HPV oncogenes modulate both the intrinsic radiation sensitivity of HNCs and also have important effects upon the tumor microenvironment. Together, these findings contribute to the improved outcomes seen in patients with HPV-positive HNC.

Indexed as

AnimalsFemaleHead and Neck NeoplasmsHumansMaleOncogene Proteins, ViralPapillomaviridaePapillomavirus InfectionsTreatment OutcomeOncogene Proteins, ViralAnal cancerCervical cancerHead and neck cancerHPVHuman papillomavirus

Identifiers

PMID26364887
PMCPMC4609293
OpenAlexW2107186122

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.