Evidence map›Paper›PMID 26364824›Full record

ArticleHearing research2016

Medial olivocochlear efferent reflex inhibition of human cochlear nerve responses.

J T Lichtenhan, U S Wilson, K E Hancock, J J Guinan

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Hearing research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed.

  1. Article
  2. Article
  3. Developing a Calibration Method to Minimize Variability in Auditory Evoked Potentials.Journal of the Association for Research in Otolaryngology : JARO · 2025
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Firing Rate Adaptation of the Human Auditory Nerve Optimizes Neural Signal-to-Noise Ratios.Journal of the Association for Research in Otolaryngology : JARO · 2022
    Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Reducing Auditory Nerve Excitability by Acute Antagonism of CaFrontiers in synaptic neuroscience · 2021
    Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

J T LichtenhanWashington University School of Medicine, Department of Otolaryngology, Saint Louis, MO 63110, USA. Electronic address: LichtenhanJ@ent.wustl.edu.
U S WilsonWashington University School of Medicine, Department of Otolaryngology, Saint Louis, MO 63110, USA; Missouri State University, Communications Sciences and Disorders, Springfield, MO 65897, USA.
K E HancockMassachusetts Eye & Ear Infirmary, Eaton-Peabody Laboratory of Auditory Physiology, Boston, MA 02114, USA; Harvard Medical School, Department of Otology and Laryngology, Boston, MA 02115, USA.
J J GuinanMassachusetts Eye & Ear Infirmary, Eaton-Peabody Laboratory of Auditory Physiology, Boston, MA 02114, USA; Harvard Medical School, Department of Otology and Laryngology, Boston, MA 02115, USA.

Funding

Olivocochlear Reflex in HumansR01DC005977 · NIDCD · MASSACHUSETTS EYE AND EAR INFIRMARY · PI GUINAN, JOHN J · 2003 to 2013
$2.8M
NIDCD NIH HHS R01 DC005977
6 · The paper itself

Abstract

Inhibition of cochlear amplifier gain by the medial olivocochlear (MOC) efferent system has several putative roles: aiding listening in noise, protection against damage from acoustic overexposure, and slowing age-induced hearing loss. The human MOC reflex has been studied almost exclusively by measuring changes in otoacoustic emissions. However, to help understand how the MOC system influences what we hear, it is important to have measurements of the MOC effect on the total output of the organ of Corti, i.e., on cochlear nerve responses that couple sounds to the brain. In this work we measured the inhibition produced by the MOC reflex on the amplitude of cochlear nerve compound action potentials (CAPs) in response to moderate level (52-60 dB peSPL) clicks from five, young, normal hearing, awake, alert, human adults. MOC activity was elicited by 65 dB SPL, contralateral broadband noise (CAS). Using tympanic membrane electrodes, approximately 10 h of data collection were needed from each subject to yield reliable measurements of the MOC reflex inhibition on CAP amplitudes from one click level. The CAS produced a 16% reduction of CAP amplitude, equivalent to a 1.98 dB effective attenuation (averaged over five subjects). Based on previous reports of efferent effects as functions of level and frequency, it is possible that much larger effective attenuations would be observed at lower sound levels or with clicks of higher frequency content. For a preliminary comparison, we also measured MOC reflex inhibition of DPOAEs evoked from the same ears with f2's near 4 kHz. The resulting effective attenuations on DPOAEs were, on average, less than half the effective attenuations on CAPs.

Indexed as

Neural InhibitionReflexAcoustic StimulationAuditory PathwaysAuditory ThresholdCochleaCochlear NerveEfferent PathwaysEvoked Potentials, AuditoryHumansOlivary NucleusOtoacoustic Emissions, SpontaneousCochlear amplifierCompound action potentialMedial olivocochlear reflexOlivocochlear efferentsOtoacoustic emissions

Identifiers

PMID26364824
PMCPMC4788580

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.