ArticleSensors (Basel, Switzerland)2015
Universal Capacitance Model for Real-Time Biomass in Cell Culture.
Article in Sensors (Basel, Switzerland), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Application of dielectric spectroscopy combined with simple linear and multivariate modelling for in-line monitoring of biomass concentration in E. coli cultures.Bioprocess and biosystems engineering · 2026Article
- Observability- and Identifiability-Guided Sensor-Set Design for Digital-Twin-Assisted Consolidated Bioprocessing.Sensors (Basel, Switzerland) · 2026Article
- Dual-Similarity Driven Just-in-Time Modeling Enables Precise Real-Time Monitoring of Cell Cultures via Dielectric Spectroscopy.Biotechnology journal · 2026Article
- Bioprocess Engineering for Cultivated Meat.Advances in biochemical engineering/biotechnology · 2026Review
- Online capacitance-integrated development of a hybrid bioprocess model for industrial fungal fermentations.Frontiers in bioengineering and biotechnology · 2026Article
- Online deployment of an O-PLS model for dielectric spectroscopy-based inline monitoring of viable cell concentrations in Chinese hamster ovary cell perfusion cultivations.Engineering in life sciences · 2023Article
- Measuring and modeling macrophage proliferation in a lab-on-CMOS capacitance sensing microsystem.Frontiers in bioengineering and biotechnology · 2023Article
- Development of process analytical tools for rapid monitoring of live virus vaccines in manufacturing.Scientific reports · 2022Article
- Two-methods approach to follow up biomass by impedance spectroscopy: Bacillus thuringiensis fermentations as a study model.Applied microbiology and biotechnology · 2022Article
- Monitoring online biomass with a capacitance sensor during scale-up of industrially relevant CHO cell culture fed-batch processes in single-use bioreactors.Bioprocess and biosystems engineering · 2020Article
- Convenient non-invasive electrochemical techniques to monitor microbial processes: current state and perspectives.Applied microbiology and biotechnology · 2019Review
- A Novel Application for Low Frequency Electrochemical Impedance Spectroscopy as an Online Process Monitoring Tool for Viable Cell Concentrations.Sensors (Basel, Switzerland) · 2016Article
- Metabolic Control in Mammalian Fed-Batch Cell Cultures for Reduced Lactic Acid Accumulation and Improved Process Robustness.Bioengineering (Basel, Switzerland) · 2016Article
- A recurrent neural network for soft sensor development using CHO stable pools in fed-batch process for SARS-CoV-2 spike protein production as a vaccine antigen.Biotechnology progressArticle
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
: Capacitance probes have the potential to revolutionize bioprocess control due to their safe and robust use and ability to detect even the smallest capacitors in the form of biological cells. Several techniques have evolved to model biomass statistically, however, there are problems with model transfer between cell lines and process conditions. Errors of transferred models in the declining phase of the culture range for linear models around +100% or worse, causing unnecessary delays with test runs during bioprocess development. The goal of this work was to develop one single universal model which can be adapted by considering a potentially mechanistic factor to estimate biomass in yet untested clones and scales. The novelty of this work is a methodology to select sensitive frequencies to build a statistical model which can be shared among fermentations with an error between 9% and 38% (mean error around 20%) for the whole process, including the declining phase. A simple linear factor was found to be responsible for the transferability of biomass models between cell lines, indicating a link to their phenotype or physiology.
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Registered trials
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