ReviewTumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine2015
Gene mutations in gastric cancer: a review of recent next-generation sequencing studies.
Review in Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed.
- Tumor microenvironment dynamics in gastric cancer pathogenesis and therapeutic resistance.Molecular cancer · 2026Review
- Targeting PI3K/AKT/mTOR and MAPK Signaling Pathways in Gastric Cancer.International journal of molecular sciences · 2024Review
- FAT4 Mutation is Related to Tumor Mutation Burden and Favorable Prognosis in Gastric Cancer.Current genomics · 2024Article
- Characteristic Mutational Damages in Gastric and Colorectal Adenocarcinomas.Asian Pacific journal of cancer prevention : APJCP · 2023Article
- Genome editing via non-viral delivery platforms: current progress in personalized cancer therapy.Molecular cancer · 2022Review
- The Wnt signaling pathway in tumorigenesis, pharmacological targets, and drug development for cancer therapy.Biomarker research · 2021Review
- TERRA Gene Expression in Gastric Cancer: Role of hTERT.Journal of gastrointestinal cancer · 2021Review
- Loss of Apc Cooperates with Activated Oncogenes to Induce Liver Tumor Formation in Mice.The American journal of pathology · 2021Article
- KMT2D promotes proliferation of gastric cancer cells: evidence from ctDNA sequencing.Journal of clinical laboratory analysis · 2021Article
- Identification and Validation of SNP-Containing Genes With Prognostic Value in Gastric CancerFrontiers in oncology · 2021Article
- Synergistic antitumor activity of a DLL4/VEGF bispecific therapeutic antibody in combination with irinotecan in gastric cancer.BMB reports · 2020Article
- Global Analyses of Expressed Piwi-Interacting RNAs in Gastric Cancer.International journal of molecular sciences · 2020Article
- Distinct prognostic values and antitumor effects of tumor growth factor β1 and its receptors in gastric cancer.Oncology letters · 2020Article
- Comprehensive Analysis ofOncoTargets and therapy · 2020Article
- Spondin 2 promotes the proliferation, migration and invasion of gastric cancer cells.Journal of cellular and molecular medicine · 2020Article
- Distinct functions and prognostic values of RORs in gastric cancer.Open medicine (Warsaw, Poland) · 2020Article
- MET in glioma: signaling pathways and targeted therapies.Journal of experimental & clinical cancer research : CR · 2019Review
- Potent and specific MTH1 inhibitors targeting gastric cancer.Cell death & disease · 2019Article
- Heat Shock Factor 1 Predicts Poor Prognosis of Gastric Cancer.Yonsei medical journal · 2018Article
- Landscape of somatic mutations in gastric cancer assessed using next-generation sequencing analysis.Oncology letters · 2018Article
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4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Gastric cancer (GC) is one of the most common malignancies worldwide. Although some driver genes have been identified in GC, the molecular compositions of GC have not been fully understood. The development of next-generation sequencing (NGS) provides a high-throughput and systematic method to identify all genetic alterations in the cancer genome, especially in the field of mutation detection. NGS studies in GC have discovered some novel driver mutations. In this review, we focused on novel gene mutations discovered by NGS studies, along with some well-known driver genes in GC. We organized mutated genes from the perspective of related biological pathways. Mutations in genes relating to genome integrity (TP53, BRCA2), chromatin remodeling (ARID1A), cell adhesion (CDH1, FAT4, CTNNA1), cytoskeleton and cell motility (RHOA), Wnt pathway (CTNNB1, APC, RNF43), and RTK pathway (RTKs, RAS family, MAPK pathway, PIK pathway) are discussed. Efforts to establish a molecular classification based on NGS data which is valuable for future targeted therapy for GC are introduced. Comprehensive dissection of the molecular profile of GC cannot only unveil the molecular basis for GC but also identify genes of clinical utility, especially potential and specific therapeutic targets for GC.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.