Evidence map›Paper›PMID 26363996›Full record

ReviewCurrent opinion in virology2015

The microbiome modulates arbovirus transmission in mosquitoes.

Shivanand Hegde, Jason L Rasgon, Grant L Hughes

Abstract readReview
In one paragraph

Review in Current opinion in virology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 123 papers.

0numbers the graph read from it
0cells of the map it votes in
123citing papers in PubMed
20.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

123 citing papers in PubMed, 225 citations in OpenAlex.

  1. Article
  2. Article
  3. Frontiers in microbiology · 2026
    Article
  4. Review
  5. Characterizing the Bacterial Microbiome of the Invasive VectorInternational journal of microbiology · 2026
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Microbial gatekeepers: midgut bacteria inFrontiers in microbiology · 2025
    Review
  14. Review
  15. Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article

63 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Shivanand HegdeDepartment of Pathology, University of Texas Medical Branch, Galveston, TX 77555, USA.
Jason L RasgonDepartment of Entomology, Pennsylvania State University, University Park, PA 16802, USA; The Huck Institutes of the Life Sciences, Pennsylvania State University, University Park, PA 16802, USA; Center for Infectious Disease Dynamics, Pennsylvania State University, University Park, PA 16802, USA.
Grant L HughesDepartment of Pathology, University of Texas Medical Branch, Galveston, TX 77555, USA; Institute for Human Infections and Immunity, University of Texas Medical Branch, Galveston, TX 77555, USA. Electronic address: glhughes@utmb.edu.
The University of Texas Medical Branch at Galveston · USPennsylvania State University · US

Funding

Genetic basis of WNV vector competence in Culex tarsalisR01AI067371 · NIAID · PENNSYLVANIA STATE UNIVERSITY, THE · PI RASGON, JASON L · 2007 to 2011
$2.0M
Wolbachia-induced enhancement of human arboviral pathogensR01AI116636 · NIAID · PENNSYLVANIA STATE UNIVERSITY, THE · PI RASGON, JASON L · 2016 to 2020
$1.9M
Efficient site-specific genetic engineering of the Anopheles gambiae genomeR21AI088311 · NIAID · PENNSYLVANIA STATE UNIVERSITY, THE · PI RASGON, JASON L · 2010 to 2011
$439k
ReMOT Control of mosquito transgenesisR21AI111175 · NIAID · PENNSYLVANIA STATE UNIVERSITY, THE · PI RASGON, JASON L · 2014 to 2015
$411k
Wolbachia-induced enhancement of human arboviral pathogensR56AI116636 · NIAID · PENNSYLVANIA STATE UNIVERSITY, THE · PI RASGON, JASON L · 2015 to 2015
$368k
NIAID NIH HHS R01 AI067371NIAID NIH HHS R01AI067371NIAID NIH HHS R01 AI116636NIAID NIH HHS R21 AI088311NIAID NIH HHS R21AI088311NIAID NIH HHS R21 AI111175NIAID NIH HHS R21AI111175NIAID NIH HHS R56 AI116636NIAID NIH HHS R56AI116636
6 · The paper itself

Abstract

Mosquito-transmitted arthropod-borne viruses (arboviruses) such as dengue virus, chikungunya virus, and West Nile virus constitute a major public health burden and are increasing in severity and frequency worldwide. The microbiota associated with mosquitoes (comprised of viruses, bacteria, fungi and protozoa) can profoundly influence many host phenotypes including vector competence, which can either be enhanced or suppressed. Thus, the tripartite interactions between the mosquito vector, its microbiota and the pathogens they transmit offer novel possibilities to control arthropod-borne diseases.

Indexed as

Host-Pathogen InteractionsMicrobiotaAnimalsArbovirusesArbovirus InfectionsCulicidaeHumansInsect VectorsMicrobial Interactions

Identifiers

PMID26363996
PMCPMC5731638
OpenAlexW1459918940

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.