Evidence map›Paper›PMID 26363933›Full record

ArticleDigestive diseases and sciences2016

Facility- and Patient-Level Factors Associated with Esophageal Variceal Screening in the USA.

Jennifer A Flemming, Varun Saxena, Hui Shen, Norah A Terrault, Catherine Rongey

Abstract read
In one paragraph

Article in Digestive diseases and sciences, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.5field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
  2. Article
  3. [Noninvasive assessment of the risk of esophageal variceal bleeding from noncirrhotic portal hypertension].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2022
    Article
  4. Article
  5. Gastrointestinal endoscopy in cirrhotic patient: Issues on the table.World journal of gastrointestinal endoscopy · 2021
    Review
  6. Review
  7. Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Jennifer A FlemmingDepartments of Medicine and Public Health Sciences, Queen's University, 166 Brock Street, S4-012, Kingston, ON, K7L 5M2, Canada. flemmij@hdh.kari.net.ORCID http://orcid.org/0000-0002-9911-0925
Varun SaxenaDepartment of Medicine, University of California San Francisco, San Francisco, CA, USA.
Hui ShenDepartment of Medicine, University of California San Francisco, San Francisco, CA, USA.
Norah A TerraultDepartment of Medicine, University of California San Francisco, San Francisco, CA, USA.
Catherine RongeyDepartment of Medicine, University of California San Francisco, San Francisco, CA, USA.
San Francisco VA Medical Center · USUniversity of California, San Francisco · USQueen's University · CA

Funding

UCSF Liver Core CenterP30DK026743 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Holger Willenbring · 1986 to 2026
$30.7M
Clinical and Transtional Science InstituteKL2TR000143 · NCATS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GRANDIS, JENNIFER RUBIN · 2012 to 2015
$11.9M
NRSA Hepatology Training GrantT32DK060414 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Mandana Khalili, JACQUELYN J. MAHER · 2002 to 2026
$6.8M
NCATS NIH HHS KL2 TR000143NIDDK NIH HHS P30 DK026743NIDDK NIH HHS T32 DK060414
6 · The paper itself

Abstract

BACKGROUND AND

aimThe American Association for the Study of Liver Disease (AASLD) recommends screening for esophageal varices (EV) by esophagoduodenoscopy (EGD) in patients with cirrhosis to guide decisions regarding primary prophylaxis for EV hemorrhage. We aimed to identify patient and facility factors associated with EV screening in veterans with hepatitis C (HCV)-associated cirrhosis.

methodsThis was a population-based cohort study. Veterans with HCV and newly diagnosed cirrhosis between 1/1/2004 and 12/31/2005 and followed until 12/31/2011 were included. The primary outcome was receipt of EGD within 1 year of cirrhosis diagnosis. Patient- and facility-level factors associated with EV screening were determined.

resultsA total of 4230 patients with HCV cirrhosis were identified. During median follow-up of 6.1 years (IQR: 4.0-8.0), 21.5 % developed a decompensating event, and 38.3 % died. Fifty-four percent received an EGD, and 33.8 % had an EGD within guidelines. Median time from cirrhosis diagnosis to EGD was 72 days (IQR: 12-176). Factors independently associated with receipt of EV screening were a decompensation event (OR 1.16, CI 1.01-1.32) and gastroenterology/hepatology clinic access (OR 2.1, CI 1.73-2.46), whereas cardiovascular (OR 0.81, CI 0.69-0.95), mental health (OR 0.79, CI 0.68-0.91), and respiratory (OR 0.85, CI 0.72-0.99) comorbidities were associated with reduced likelihood of EV screening.

conclusionEV screening per AASLD guidelines occurs in only one-third of patients. This missed opportunity was strongly associated with access to gastroenterology/hepatology specialty care. Additionally, providers may be relying on clinical cues (i.e., decompensation) to prompt referral for endoscopy suggesting education to improve compliance with guidelines is needed.

Indexed as

Endoscopy, GastrointestinalHealth FacilitiesPractice Patterns, Physicians'Referral and ConsultationChi-Square DistributionComorbidityDatabases, FactualDisease ProgressionEsophageal and Gastric VaricesFemaleGuideline AdherenceHepatitis CHumansLiver CirrhosisLogistic ModelsMaleCirrhosisEndoscopyHepatitis CVariceal screening

Identifiers

PMID26363933
PMCPMC4809672
OpenAlexW1623994133

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.