ReviewJournal of controlled release : official journal of the Controlled Release Society2015
Current strategies for sustaining drug release from electrospun nanofibers.
Review in Journal of controlled release : official journal of the Controlled Release Society, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 142 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
142 citing papers in PubMed.
- Probing Nanoscale Features of Electrospun Amorphous Solid Dispersions Using Advanced Biophysical Analysis.Molecular pharmaceutics · 2026Article
- Tailoring Drug Release Profiles From Electrospun Alginate Fibers Through Integration of Mesoporous Silica Nanoparticles.Advanced healthcare materials · 2026Article
- Untreated Rosehip Powder/Poly(Lactic Acid)/Poly(3-Hydroxybutyrate-Co-4-Hydroxybutyrate) Electrospun Mats for Wound Dressing Applications.Biopolymers · 2026Article
- Electrospun nanofibers for antibiotic and probiotic co-delivery to target bacterial vaginosis.International journal of pharmaceutics · 2026Article
- Agave-Derived Carbon Dots Incorporated into PVA/Chitosan Nanofibers for Prolonged Antibacterial Activity.ACS omega · 2026Article
- Design and preparation of novel domperidone loaded polymeric blend electrospun nanofibers for improved oral pharmacodynamic activity.Drug delivery and translational research · 2026Article
- Bio-degradable electrospun nanofibers encompassing dioxidovanadium benzimidazole compounds as potential drug delivery systems for diabetes mellitus.RSC advances · 2026Article
- Polymer Nanoparticles in Medical Applications-Future Directions.Nanomaterials (Basel, Switzerland) · 2026Review
- The Potential of Electrospun Meshes in Postoperative Pain Management.Pharmaceutics · 2026Review
- Innovative AC Electrospinning and Characterization of Nanofibers Comprised of Polyvinyl Alcohol and Dacarbazine for Solid State Drug Delivery of Cancer Therapeutic.BioNanoScience · 2026Article
- Rationalization Progress of Novel Drug Delivery System for Intra-periodontal Pockets Against Periodontitis.Pharmaceutical nanotechnology · 2026Review
- The Development of Risperidone-Loaded Microfibers via Centrifugal Spinning to Enhance the Palatability of a Potential Drug for Autistic Children.Pharmaceutics · 2025Article
- Composite Hydrogels with Embedded Electrospun Fibers as Drug Delivery Systems.Gels (Basel, Switzerland) · 2025Review
- Programmable Fabrics of Enzyme-Responsive Amphiphiles: A Multiscale Platform for Hierarchical Mesophase Transformations.Biomacromolecules · 2025Article
- Potential of Chitosan/Gelatin-Based Nanofibers in Delivering Drugs for the Management of Varied Complications: A Review.Polymers · 2025Review
- Electrospun nanofibers: Focus on local therapeutic delivery targeting infectious disease.Journal of drug delivery science and technology · 2025Article
- Fiber Technology in Drug Delivery and Pharmaceuticals.Current drug delivery · 2025Review
- Sustained Delivery of Chondrogenic Molecules Using Sugar Glass Nanoparticle-Integrated Fibrous Scaffolds for Cartilage Tissue Engineering.Regenerative engineering and translational medicine · 2025Article
- Antibacterial Electrospun Membrane with Hierarchical Bead-on-String Structured Fibres for Wound Infections.Nanomaterials (Basel, Switzerland) · 2024Article
- Silybin-Functionalized PCL Electrospun Fibrous Membranes for Potential Pharmaceutical and Biomedical Applications.Polymers · 2024Article
82 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Electrospun drug-eluting fibers are emerging as a novel dosage form for multipurpose prevention against sexually transmitted infections, including HIV, and unintended pregnancy. Previous work from our lab and others show the versatility of this platform to deliver large doses of physico-chemically diverse agents. However, there is still an unmet need to develop practical fiber formulations for water-soluble small molecule drugs needed at high dosing due to intrinsic low potency or desire for sustained prevention. To date, most sustained release fibers have been restricted to the delivery of biologics or hydrophobic small molecules at low drug loading of typically <1 wt.%, which is often impractical for most clinical applications. For hydrophilic small molecule drugs, their high aqueous solubility and poor partitioning and incompatibility with insoluble polymers make long-term release even more challenging. Here we investigate several existing strategies to sustain release of hydrophilic small molecule drugs that are highly-loaded in electrospun fibers. In particular, we investigate what is known about the design constraints required to realize multi-day release from fibers fabricated from uniaxial and coaxial electrospinning.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.