Evidence map›Paper›PMID 26363126›Full record

ArticleDevelopmental biology2015

Perturbed meibomian gland and tarsal plate morphogenesis by excess TGFα in eyelid stroma.

Fei Dong, Chia-Yang Liu, Yong Yuan, Yujin Zhang, Wei Li, Mindy Call, Liyun Zhang, Yongxiong Chen, Zuguo Liu, Winston W Y Kao

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Developmental biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.3field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Review
  6. Genetically modified laboratory mice with sebaceous glands abnormalities.Cellular and molecular life sciences : CMLS · 2016
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Fei DongDepartment of Ophthalmology, University of Cincinnati, OH 45267, United States; Eye Institute of Xiamen University, Xiamen, Fujian 361102, People's Republic of China.
Chia-Yang LiuDepartment of Ophthalmology, University of Cincinnati, OH 45267, United States.
Yong YuanDepartment of Ophthalmology, University of Cincinnati, OH 45267, United States.
Yujin ZhangDepartment of Ophthalmology, University of Cincinnati, OH 45267, United States.
Wei LiEye Institute of Xiamen University, Xiamen, Fujian 361102, People's Republic of China.
Mindy CallDepartment of Ophthalmology, University of Cincinnati, OH 45267, United States.
Liyun ZhangDepartment of Ophthalmology, University of Cincinnati, OH 45267, United States.
Yongxiong ChenEye Institute of Xiamen University, Xiamen, Fujian 361102, People's Republic of China.
Zuguo LiuEye Institute of Xiamen University, Xiamen, Fujian 361102, People's Republic of China. Electronic address: zuguoliu@xmu.edu.cn.
Winston W Y KaoDepartment of Ophthalmology, University of Cincinnati, OH 45267, United States. Electronic address: kaoww@uc.edu.
University of Cincinnati · USXiamen University · CN

Funding

Structure/Function Relationship of The Lumican GeneR01EY011845 · NEI · UNIVERSITY OF CINCINNATI · PI KAO, WINSTON W · 1999 to 2017
$5.2M
Roles of Growth Factors on Corneal MorphogenesisR01EY013755 · NEI · UNIVERSITY OF CINCINNATI · PI KAO, WINSTON W · 2002 to 2013
$4.0M
Left-Right Asymmetry of the Developing DiencephalonR01HD042215 · NICHD · CARNEGIE INSTITUTION OF WASHINGTON, D.C. · PI HALPERN, MARNIE E · 2003 to 2013
$3.3M
Mouse Model for Eyelid Disease: Congenital BlepharophimosisR01EY021501 · NEI · UNIVERSITY OF CINCINNATI · PI LIU, CHIA-YANG · 2011 to 2015
$1.9M
NEI NIH HHS EY011845NEI NIH HHS EY21501NEI NIH HHS R01 EY011845NEI NIH HHS R01 EY013755NEI NIH HHS R01 EY021501NICHD NIH HHS 5R01HD042215-10
6 · The paper itself

Abstract

Transforming growth factor alpha (TGFα) belongs to the epidermal growth factor (EGF) family and is known to play an important role during eyelid morphogenesis. In this study, we showed that ectopic expression of TGFα in the stroma of Kera-rtTA/tet-O-TGFα bitransgenic mice results in precocious eye opening, abnormal morphogenesis of the meibomian gland, tendon and tarsal plate malformation and epithelium hyperplasia. TGFα did not change proliferation and differentiation of meibocytes, but promoted proliferation and inhibited differentiation of the tarsal plate tenocytes. These results suggest that proper formation of the tendon and tarsal plate in the mouse eyelid is required for normal morphogenesis of the meibomian gland.

Indexed as

AnimalsCell DifferentiationCell ProliferationDNA PrimersEyelidsGene Expression Regulation, DevelopmentalHistological TechniquesImmunohistochemistryMeibomian GlandsMiceMice, TransgenicMorphogenesisPolymerase Chain ReactionTendonsTransforming Growth Factor alphaDNA PrimersTransforming Growth Factor alphaECMEyelid developmentEyelid tendonMeibomian gland morphogenesisTarsal plateTGFα

Identifiers

PMID26363126
PMCPMC4996271
OpenAlexW1871713248

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.