Evidence map›Paper›PMID 26362910›Full record

ArticleBrain : a journal of neurology2016

CHCHD10 Pro34Ser is not a highly penetrant pathogenic variant for amyotrophic lateral sclerosis and frontotemporal dementia.

Samir Abdelkarim, Sarah Morgan, Vincent Plagnol, Ching-Hua Lu, Gary Adamson, Robin Howard, Andrea Malaspina, Richard Orrell, Nikhil Sharma, Katie Sidle and 10 more

Abstract readLetter
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain : a journal of neurology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Meta-analysis of the association between CHCHD10 Pro34Ser variant and the risk of amyotrophic lateral sclerosis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2021
    Pooled it
  2. Article
  3. Article
  4. ALS: Recent Developments from Genetics Studies.Current neurology and neuroscience reports · 2016
    Review
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Samir Abdelkarim1 Department of Neurodegenerative Disease, University College London Institute of Neurology, Queen Square, London WC1N 3BG, UK.
Sarah Morgan2 Department of Molecular Neuroscience, University College London Institute of Neurology, Queen Square, London WC1N 3BG, UK.
Vincent Plagnol3 UCL Genetics Institute, Department of Genetics, Environment and Evolution, UCL, London WC1E 6BT, UK.
Ching-Hua Lu4 Sobell Department of Motor Neuroscience and Movement Disorders, Queen Square, London, WC1N 3BG, UK 5 Centre for Neuroscience and Trauma, Blizard Institute, Queen Mary University of London, North-East London and Essex Regional MND Care Centre, E1 2AT, UK.
Gary Adamson6 Medical Research Council Prion Unit, Department of Neurodegenerative Disease, University College London Institute of Neurology, Queen Square, London, WC1N 3BG, UK.
Robin Howard7 National Hospital for Neurology and Neurosurgery, Queen Square, London, WC1N 3BG, UK.
Andrea Malaspina5 Centre for Neuroscience and Trauma, Blizard Institute, Queen Mary University of London, North-East London and Essex Regional MND Care Centre, E1 2AT, UK.
Richard Orrell2 Department of Molecular Neuroscience, University College London Institute of Neurology, Queen Square, London WC1N 3BG, UK.
Nikhil Sharma4 Sobell Department of Motor Neuroscience and Movement Disorders, Queen Square, London, WC1N 3BG, UK.
Katie Sidle2 Department of Molecular Neuroscience, University College London Institute of Neurology, Queen Square, London WC1N 3BG, UK.
Jan Clarke7 National Hospital for Neurology and Neurosurgery, Queen Square, London, WC1N 3BG, UK.
Nick C Fox8 Dementia Research Centre, Department of Neurodegenerative Disease, University College London Institute of Neurology, Queen Square, London WC1N 3BG, UK.
Martin N Rossor8 Dementia Research Centre, Department of Neurodegenerative Disease, University College London Institute of Neurology, Queen Square, London WC1N 3BG, UK.
Jason D Warren8 Dementia Research Centre, Department of Neurodegenerative Disease, University College London Institute of Neurology, Queen Square, London WC1N 3BG, UK.
Camilla N Clark8 Dementia Research Centre, Department of Neurodegenerative Disease, University College London Institute of Neurology, Queen Square, London WC1N 3BG, UK.
Jonathan D Rohrer8 Dementia Research Centre, Department of Neurodegenerative Disease, University College London Institute of Neurology, Queen Square, London WC1N 3BG, UK.
Elizabeth M C Fisher1 Department of Neurodegenerative Disease, University College London Institute of Neurology, Queen Square, London WC1N 3BG, UK.
Simon Mead6 Medical Research Council Prion Unit, Department of Neurodegenerative Disease, University College London Institute of Neurology, Queen Square, London, WC1N 3BG, UK.
Alan Pittman2 Department of Molecular Neuroscience, University College London Institute of Neurology, Queen Square, London WC1N 3BG, UK.
Pietro Fratta1 Department of Neurodegenerative Disease, University College London Institute of Neurology, Queen Square, London WC1N 3BG, UK 4 Sobell Department of Motor Neuroscience and Movement Disorders, Queen Square, London, WC1N 3BG, UK p.fratta@ucl.ac.uk.

Funding

Medical Research Council MC_U123160651Medical Research Council MR/K018523/1Medical Research Council MR/M008525/1Medical Research Council MR/M008606/1Motor Neurone Disease Association FRATTA/JAN15/946-795Wellcome Trust 091673/Z/10/Z
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

PenetranceAmyotrophic Lateral SclerosisCohort StudiesFrontotemporal DementiaGenetic VariationHumansMitochondrial ProteinsMutationProlineSerineCHCHD10 protein, humanMitochondrial ProteinsProlineSerine

Identifiers

PMID26362910
PMCPMC5963427

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.