ArticleClinical research in cardiology : official journal of the German Cardiac Society2016
The value of noncoronary atherosclerosis for identifying coronary artery disease: results of the Leipzig LIFE Heart Study.
Article in Clinical research in cardiology : official journal of the German Cardiac Society, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00497887 (Observational Study for Identification of Genetic- and Biological-Markers of Predisposition to Atherosclerosis), which is not on this map. Cited by 10 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Observational Study for Identification of Genetic- and Biological-Markers of Predisposition to Atherosclerosis: Leipzig-Heart Study (LE-Heart)
Who cites it
10 citing papers in PubMed, 18 citations in OpenAlex.
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- Brain Damage With Heart Failure: Cardiac Biomarker Alterations and Gray Matter Decline.Circulation research · 2020Article
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- Association between hyperleptinemia and cardiovascular outcomes in patients with coronary artery disease.Therapeutics and clinical risk management · 2018Article
- Target blood pressure in high risk cardiovascular patients.Journal of thoracic disease · 2017Article
- Low circulating microRNA levels in heart failure patients are associated with atherosclerotic disease and cardiovascular-related rehospitalizations.Clinical research in cardiology : official journal of the German Cardiac Society · 2017Article
- In-stent restenosis after interventional treatment of carotid artery stenoses: a long-term follow-up of a single center cohort.Clinical research in cardiology : official journal of the German Cardiac Society · 2017Article
- Evaluation of the systemic micro- and macrovasculature in stable angina: A case-control study.PloS one · 2017Article
- Differences between perivascular adipose tissue surrounding the heart and the internal mammary artery: possible role for the leptin-inflammation-fibrosis-hypoxia axis.Clinical research in cardiology : official journal of the German Cardiac Society · 2016Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDespite the widespread use of noninvasive testing prior to invasive coronary diagnostic the diagnostic yield of elective coronary angiography has been reported low in subjects with suspected obstructive CAD.
objectiveTo determine the predictive value of noncoronary atherosclerosis (NCA) in subjects with suspected stable coronary artery disease (CAD) intended to invasive coronary angiography.
methodsUltrasound-based assessment of carotid artery plaque (CAP), carotid intima-media thickness (CIMT) and ankle-brachial index (ABI) was performed in 2216 subjects with suspected CAD prior to coronary angiography. Logistic regression and c-statistics were used to analyze the diagnostic value of NCA for the presence of obstructive CAD and the intention to revascularization.
resultsPercentage of positive results of elective coronary angiography was low but comparable to other studies (41% obstructive CAD). We identified 1323 subjects (60%) with NCA, most of them were characterized by CAP (93%). CAP independently predicted obstructive CAD in addition to traditional risk factors and clinical factors while CIMT and ABI failed to improve the prediction. The presence of NCA and typical angina were the strongest predictors for obstructive CAD (OR 4.0 and 2.4, respectively). A large subgroup of patients (n = 703, 32%) with atypical clinical presentation and lack of NCA revealed a low indication for revascularization <15% indicating a large proportion of subjects with non-obstructive CAD in this subgroup.
conclusionThe evaluation of noncoronary atherosclerosis has the potential to impact clinical decision making and to direct subsequent diagnostic procedures in subjects with suspected coronary artery disease. CLINICAL
trial registrationNCT00497887.
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