Evidence map›Paper›PMID 26362783›Full record

SynthesisJournal of orthopaedics and traumatology : official journal of the Italian Society of Orthopaedics and Traumatology2016

Platelet-rich plasma versus autologous blood versus steroid injection in lateral epicondylitis: systematic review and network meta-analysis.

Alisara Arirachakaran, Amnat Sukthuayat, Thaworn Sisayanarane, Sorawut Laoratanavoraphong, Wichan Kanchanatawan, Jatupon Kongtharvonskul

2 registry-linked trialsOpen access · goldAbstract readSystematic ReviewNetwork Meta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Journal of orthopaedics and traumatology : official journal of the Italian Society of Orthopaedics and Traumatology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 65 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
65citing papers in PubMed, 7 pooled it
9.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05602571 nacompletednot on this mapstarted 2022, after this paper: background citation

Effects of Adding Platelet-Rich Plasma (PRP) Therapy to Extracorporeal Shock Wave Therapy (ESWT) in Patients With Lateral Epicondylitis: Double-Blind Randomized Sham-Controlled Study

TypeinterventionalSponsorAfyonkarahisar Health Sciences UniversityRan2022 to 2024Enrolled91ConditionsMusculoskeletal Diseases, Elbow Tendinitis, Lateral Epicondylitis, Platelet-Rich Plasma (PRP)ArmsESWT+Exercise, PRP+ESWT+Exercise, Sham PRP+ESWT+Exercise
NCT06236178 nacompletednot on this mapstarted 2023, after this paper: background citation

Comparing Autologous Blood, Corticosteroid, and Their Combined Injection for Treating Lateral Epicondylitis: A Randomized Clinical Trial

TypeinterventionalSponsorIstanbul Training and Research HospitalRan2023 to 2023Enrolled119ConditionsLateral Epicondylitis, Comparing Autologous Blood Corticosteroid and Their Combined Injection for Treating Lateral EpicondylitisArmsCorticosteroid, Autologous Blood, Local Anesthetic
3 · Its place in the literature

Who cites it

65 citing papers in PubMed, 7 syntheses or guidelines pooled it, 159 citations in OpenAlex.

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  10. Comparing autologous blood, corticosteroid, and a combined injection of both for treating lateral epicondylitis: a randomized clinical trial.Journal of orthopaedics and traumatology : official journal of the Italian Society of Orthopaedics and Traumatology · 2024
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5 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Alisara ArirachakaranOrthopedics Department, Police General Hospital, Bangkok, Thailand.
Amnat SukthuayatOrthopedics Department, Police General Hospital, Bangkok, Thailand.
Thaworn SisayanaraneOrthopedics Department, Police General Hospital, Bangkok, Thailand.
Sorawut LaoratanavoraphongOrthopedics Department, Police General Hospital, Bangkok, Thailand.
Wichan KanchanatawanOrthopedics Department, Lerdsin General Hospital, Bangkok, Thailand.
Jatupon KongtharvonskulSection for Clinical Epidemiology and Biostatistics, Faculty of Medicine, Ramathibodi Hospital, Bangkok, Thailand. Jatupon_kong@hotmail.com.
Police General Hospital · THLerdsin Hospital · THRamathibodi Hospital · TH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundClinical outcomes between the use of platelet-rich plasma (PRP), autologous blood (AB) and corticosteroid (CS) injection in lateral epicondylitis are still controversial. MATERIALS AND

methodsA systematic review and network meta-analysis of randomized controlled trials was conducted with the aim of comparing relevant clinical outcomes between the use of PRP, AB and CS injection. Medline and Scopus databases were searched from inception to January 2015. A network meta-analysis was performed by applying weight regression for continuous outcomes and a mixed-effect Poisson regression for dichotomous outcomes.

resultsTen of 374 identified studies were eligible. When compared to CS, AB injection showed significantly improved effects with unstandardized mean differences (UMD) in pain visual analog scale (VAS), Disabilities of Arm Shoulder and Hand (DASH), Patient-Related Tennis Elbow Evaluation (PRTEE) score and pressure pain threshold (PPT) of -2.5 (95 % confidence interval, -3.5, -1.5), -25.5 (-33.8, -17.2), -5.3 (-9.1, -1.6) and 9.9 (5.6, 14.2), respectively. PRP injections also showed significantly improved VAS and DASH scores when compared with CS. PRP showed significantly better VAS with UMD when compared to AB injection. AB injection has a higher risk of adverse effects, with a relative risk of 1.78 (1.00, 3.17), when compared to CS. The network meta-analysis suggested no statistically significant difference in multiple active treatment comparisons of VAS, DASH and PRTEE when comparing PRP and AB injections. However, AB injection had improved DASH score and PPT when compared with PRP injection. In terms of adverse effects, AB injection had a higher risk than PRP injection.

conclusionsThis network meta-analysis provided additional information that PRP injection can improve pain and lower the risk of complications, whereas AB injection can improve pain, disabilities scores and pressure pain threshold but has a higher risk of complications. LEVEL OF EVIDENCE: Level I evidence.

Indexed as

Platelet-Rich PlasmaAdrenal Cortex HormonesDisability EvaluationHumansInjectionsPain ManagementPain MeasurementRandomized Controlled Trials as TopicTennis ElbowAdrenal Cortex HormonesAutologous bloodCorticosteroidLateral epicondylitisNetwork meta-analysisPRPSystematic review

Identifiers

PMID26362783
PMCPMC4882297
OpenAlexW1899264750

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.