ArticleBMJ open2015
Long-term musculoskeletal morbidity after adult burn injury: a population-based cohort study.
Article in BMJ open, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 46 citations in OpenAlex.
- Quantification of an Exercise Rehabilitation Program for Severely Burned Children: The Standard of Care at Shriners Hospitals for Children®-Galveston.Journal of burn care & research : official publication of the American Burn Association · 2018Guideline
- Skeletal Muscle Mitochondrial Function is Determined by Burn Severity, Sex, and Sepsis, and is Associated With Glucose Metabolism and Functional Capacity in Burned Children.Shock (Augusta, Ga.) · 2018Trial
- Propranolol kinetics in plasma from severely burned adults.Burns : journal of the International Society for Burn Injuries · 2017Trial
- Factors Affecting Quality of Life in Post-Burn Patients: A Cross-Sectional Study in Indonesia.Annals of burns and fire disasters · 2025Article
- Burn Injuries Accelerate Biological Aging and Increase the Epigenetically Inferred Risk of Mortality and Frailty.Aging and disease · 2025Article
- Nonsevere Burn Induces a Prolonged Systemic Metabolic Phenotype Indicative of a Persistent Inflammatory Response Postinjury.Journal of proteome research · 2024Article
- Navigating Post-Traumatic Osteoporosis: A Comprehensive Review of Epidemiology, Pathophysiology, Diagnosis, Treatment, and Future Directions.Life (Basel, Switzerland) · 2024Review
- Effects of early exercise training following severe burn injury: a randomized controlled trial.Burns & trauma · 2024Article
- Current understanding of the chronic stress response to burn injury from human studies.Burns & trauma · 2023Review
- Healing Mechanisms in Cutaneous Wounds: Tipping the Balance.Tissue engineering. Part B, Reviews · 2022Review
- Development and Validation of Indicators for Population Injury Surveillance in Hong Kong: Development and Usability Study.JMIR public health and surveillance · 2022Review
- Non-severe burn injury increases cancer incidence in mice and has long-term impacts on the activation and function of T cells.Burns & trauma · 2022Article
- Rehabilitative Exercise Training for Burn Injury.Sports medicine (Auckland, N.Z.) · 2021Review
- Skeletal muscle wasting after a severe burn is a consequence of cachexia and sarcopenia.JPEN. Journal of parenteral and enteral nutrition · 2021Review
- Burn injury.Nature reviews. Disease primers · 2020Review
- Predictors of generic and burn-specific quality of life among adult burn patients admitted to a Lebanese burn care center: a cross-sectional single-center study.International journal of burns and trauma · 2020Article
- Pediatric Burn Survivors Have Long-Term Immune Dysfunction With Diminished Vaccine Response.Frontiers in immunology · 2020Article
- Determinants of skeletal muscle protein turnover following severe burn trauma in children.Clinical nutrition (Edinburgh, Scotland) · 2019Observational
- Risk of osteoporosis and fracture in victims with burn injury.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2019Article
- Understanding acute burn injury as a chronic disease.Burns & trauma · 2019Review
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo investigate if adults who are hospitalised for a burn injury have increased long-term hospital use for musculoskeletal diseases.
designA population-based retrospective cohort study using linked administrative health data from the Western Australian Data Linkage System. SUBJECTS: Records of 17,753 persons aged at least 20 years when hospitalised for a first burn injury in Western Australia during the period 1980-2012, and 70,758 persons who were age and gender-frequency matched with no injury admissions randomly selected from Western Australia's electoral roll.
main outcome measuresAdmission rates and cumulative length of stay for musculoskeletal diseases. Negative binomial and Cox proportional hazards regression modelling were used to generate incidence rate ratios (IRR) and HRs with 95% CIs, respectively.
resultsAfter adjustment for pre-existing health status and demographic characteristics, the burn cohort had almost twice the hospitalisation rate for a musculoskeletal condition (IRR, 95% CI 1.98, 1.86 to 2.10), and spent 3.70 times as long in hospital with a musculoskeletal diagnosis (95% CI 3.10 to 4.42) over the 33-year period, than the uninjured comparison cohort. Adjusted survival analyses of incident post-burn musculoskeletal disease admissions found significant increases for the 15-year post burn discharge period (0-6 months: HR, 95% CI 2.51, 2.04 to 3.11; 6 months-2 years: HR, 95% CI 1.77, 1.53 to 2.05; 2-15 years: HR, 95% CI 1.32, 1.23 to 1.42). Incident admission rates were significantly elevated for 20 years post-burn for minor and severe burn injury for a range of musculoskeletal diseases that included arthropathies, dorsopathies, osteopathies and soft tissue disorders.
conclusionsMinor and severe burn injuries were associated with significantly increased post-burn incident admission rates, long-term hospital use and prolonged length of stay for a range of musculoskeletal diseases. Further research is required that facilitates identification of at-risk patients and appropriate treatment pathways, to reduce the long-term morbidity associated with burns.
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