ArticleThe journals of gerontology. Series B, Psychological sciences and social sciences2016
Vascular Health and Genetic Risk Affect Mild Cognitive Impairment Status and 4-Year Stability: Evidence From the Victoria Longitudinal Study.
Article in The journals of gerontology. Series B, Psychological sciences and social sciences, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.
- Personality associations with lung function and dyspnea: Evidence from six studies.Respiratory medicine · 2023Pooled it
- Childhood respiratory risk profiles associate with lung function and COPD among the old population.Annals of medicine · 2025Article
- Alterations in the inflammatory homeostasis of aging-related cardiac dysfunction and Alzheimer's diseases.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025Review
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- Association of Unhealthy Lifestyle and Genetic Risk Factors With Mild Cognitive Impairment in Chinese Older Adults.JAMA network open · 2023Article
- Using multivariate base rates of low scores to understand early cognitive declines on the uniform data set 3.0 Neuropsychological Battery.Neuropsychology · 2020Article
- Targeted Nutritional Intervention for Patients with Mild Cognitive Impairment: The Cognitive impAiRmEnt Study (CARES) Trial 1.Journal of personalized medicine · 2020Article
- Associations of APOE ε4 With Health and Financial Literacy Among Community-Based Older Adults Without Dementia.The journals of gerontology. Series B, Psychological sciences and social sciences · 2018Article
- Contrasting olfaction, vision, and audition as predictors of cognitive change and impairment in non-demented older adults.Neuropsychology · 2018Article
- Personality and Lung Function in Older Adults.The journals of gerontology. Series B, Psychological sciences and social sciences · 2017Article
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Authors and funding
6 authors at 2 institutions in 1 country.
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Abstract
objectivesMild cognitive impairment (MCI) is a high-risk condition for progression to Alzheimer's disease (AD). Vascular health is a key mechanism underlying age-related cognitive decline and neurodegeneration. AD-related genetic risk factors may be associated with preclinical cognitive status changes. We examine independent and cross-domain interactive effects of vascular and genetic markers for predicting MCI status and stability.
methodWe used cross-sectional and 2-wave longitudinal data from the Victoria Longitudinal Study, including indicators of vascular health (e.g., reported vascular diseases, measured lung capacity and pulse rate) and genetic risk factors-that is, apolipoprotein E (APOE; rs429358 and rs7412; the presence vs absence of ε4) and catechol-O-methyltransferase (COMT; rs4680; met/met vs val/val). We examined associations with objectively classified (a) cognitive status at baseline (not impaired congnitive (NIC) controls vs MCI) and (b) stability or transition of cognitive status across a 4-year interval (stable NIC-NIC vs chronic MCI-MCI or transitional NIC-MCI).
resultsUsing logistic regression, indicators of vascular health, both independently and interactively with APOE ε4, were associated with risk of MCI at baseline and/or associated with MCI conversion or MCI stability over the retest interval. DISCUSSION: Several vascular health markers of aging predict MCI risk. Interactively, APOE ε4 may intensify the vascular health risk for MCI.
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