ArticleCirculation. Cardiovascular genetics2015
Molecular Characterization of the NLRC4 Expression in Relation to Interleukin-18 Levels.
Article in Circulation. Cardiovascular genetics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 23 citations in OpenAlex.
- Variants in inflammation-related genes influence the outcomes of physical exercise programs: A longitudinal study in Brazilian adolescents with overweight and obesity.Genetics and molecular biology · 2024Article
- Biological and clinical roles of IL-18 in inflammatory diseases.Nature reviews. Rheumatology · 2024Review
- Rapid Inflammasome Activation Is Attenuated in Post-Myocardial Infarction Monocytes.Frontiers in immunology · 2022Article
- Article
- Inflammasome genetics and complex diseases: a comprehensive review.European journal of human genetics : EJHG · 2020Review
- A Common NLRC4 Gene Variant Associates With Inflammation and Pulmonary Function in Human Immunodeficiency Virus and Tuberculosis.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2020Article
- Epigenetics meets proteomics in an epigenome-wide association study with circulating blood plasma protein traits.Nature communications · 2020Article
- Combining Host Genetics and Functional Analysis to Depict Inflammasome Contribution in Tuberculosis Susceptibility and Outcome in Endemic Areas.Frontiers in immunology · 2020Article
- Associations between NLRC4 Gene Polymorphisms and Autoimmune Thyroid Disease.BioMed research international · 2020Article
- Polymorphisms of theDiabetes, metabolic syndrome and obesity : targets and therapy · 2020Article
- Systemic inflammation and causal risk for Alzheimer's dementia: Possibilities and limitations of a Mendelian randomization approach.Aging medicine (Milton (N.S.W)) · 2018Article
- Common Variation inOpen forum infectious diseases · 2018Article
- Expression of specific inflammasome gene modules stratifies older individuals into two extreme clinical and immunological states.Nature medicine · 2017Article
- Cannabinoids as Key Regulators of Inflammasome Signaling: A Current Perspective.Frontiers in immunologyReview
Corrections and comments
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Authors and funding
29 authors at 7 institutions in 6 countries.
Funding
Abstract
backgroundInterleukin-18 (IL-18) is a pleiotropic cytokine centrally involved in the cytokine cascade with complex immunomodulatory functions in innate and acquired immunity. Circulating IL-18 concentrations are associated with type 2 diabetes mellitus, cardiovascular events, and diverse inflammatory and autoimmune disorders. METHODS AND
resultsTo identify causal variants affecting circulating IL-18 concentrations, we applied various omics and molecular biology approaches. By genome-wide association study, we confirmed association of IL-18 levels with a single nucleotide polymorphism in the untranslated exon 2 of the inflammasome component NLRC4 (NLR family, caspase recruitment domain-containing 4) gene on chromosome 2 (rs385076; P=2.4 × 10(-45)). Subsequent molecular analyses by gene expression analysis and reporter gene assays indicated an effect of rs385076 on NLRC4 expression and differential isoform usage by modulating binding of the transcription factor PU.1.
conclusionsOur study provides evidence for the functional causality of single nucleotide polymorphism rs385076 within the NLRC4 gene in relation to IL-18 activation.
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