Evidence map›Paper›PMID 26362265›Full record

ArticleImmunity2015

Tissue-Specific Distribution of iNKT Cells Impacts Their Cytokine Response.

You Jeong Lee, Haiguang Wang, Gabriel J Starrett, Vanessa Phuong, Stephen C Jameson, Kristin A Hogquist

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Immunity, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 210 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
210citing papers in PubMed, 1 pooled it
12.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

210 citing papers in PubMed, 1 synthesis or guideline pooled it, 281 citations in OpenAlex.

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  12. Metabolic control of innate-like T cells.Nature reviews. Immunology · 2026
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150 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

You Jeong LeeThe Department of Laboratory Medicine and Pathology, Center for Immunology, University of Minnesota, Minneapolis, MN 55455, USA.
Haiguang WangThe Department of Laboratory Medicine and Pathology, Center for Immunology, University of Minnesota, Minneapolis, MN 55455, USA.
Gabriel J StarrettBiochemistry, Molecular Biology and Biophysics Department, University of Minnesota, Minneapolis, MN 55455, USA.
Vanessa PhuongPublic Health Studies and Biology, Johns Hopkins University, Baltimore, MD 21218, USA.
Stephen C JamesonThe Department of Laboratory Medicine and Pathology, Center for Immunology, University of Minnesota, Minneapolis, MN 55455, USA.
Kristin A HogquistThe Department of Laboratory Medicine and Pathology, Center for Immunology, University of Minnesota, Minneapolis, MN 55455, USA. Electronic address: hogqu001@umn.edu.
University of Minnesota · USJohns Hopkins University · US

Funding

Women's CancerP30CA077598 · NCI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI Douglas Yee · 1998 to 2026
$100.4M
TCR signal strength in thymic selectionR37AI039560 · NIAID · UNIVERSITY OF MINNESOTA · PI HOGQUIST, KRISTIN A. · 2012 to 2021
$3.7M
Peptide induction of positive selectionR01AI039560 · NIAID · UNIVERSITY OF MINNESOTA TWIN CITIES · PI HOGQUIST, KRISTIN A. · 2001 to 2010
$3.1M
Homeostatic Proliferation and Memory CD8 T CellsR01AI075168 · NIAID · UNIVERSITY OF MINNESOTA · PI JAMESON, STEPHEN C · 2008 to 2016
$3.1M
iNKT cells regulate IL-4 homeostasis and autoimmunityK99AI114884 · NIAID · UNIVERSITY OF MINNESOTA · PI LEE, YU-JUNG · 2015 to 2015
$94k
NCI NIH HHS P30 CA077598NIAID NIH HHS K99 AI114884NIAID NIH HHS K99-AI114884NIAID NIH HHS R01 AI039560NIAID NIH HHS R01 AI075168NIAID NIH HHS R01-AI075168NIAID NIH HHS R37 AI039560NIAID NIH HHS R37-AI39560
6 · The paper itself

Abstract

Three subsets of invariant natural killer T (iNKT) cells have been identified, NKT1, NKT2, and NKT17, which produce distinct cytokines when stimulated, but little is known about their localization. Here, we have defined the anatomic localization and systemic distribution of these subsets and measured their cytokine production. Thymic NKT2 cells that produced interleukin-4 (IL-4) at steady state were located in the medulla and conditioned medullary thymocytes. NKT2 cells were abundant in the mesenteric lymph node (LN) of BALB/c mice and produced IL-4 in the T cell zone that conditioned other lymphocytes. Intravenous injection of α-galactosylceramide activated NKT1 cells with vascular access, but not LN or thymic NKT cells, resulting in systemic interferon-γ and IL-4 production, while oral α-galactosylceramide activated NKT2 cells in the mesenteric LN, resulting in local IL-4 release. These findings indicate that the localization of iNKT cells governs their cytokine response both at steady state and upon activation.

Indexed as

AnimalsCells, CulturedCytokinesFlow CytometryFluorescent Antibody TechniqueGalactosylceramidesInterferon-gammaInterleukin-4LiverLungLymph NodesLymphocyte ActivationMice, Inbred BALB CMice, Inbred C57BLMice, Inbred NODMice, Knockoutalpha-galactosylceramideCytokinesGalactosylceramidesInterferon-gammaInterleukin-4

Identifiers

PMID26362265
PMCPMC4575275
OpenAlexW1768853402

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.