ReviewThe Lancet. Infectious diseases2015
Challenges and key research questions for yaws eradication.
Review in The Lancet. Infectious diseases, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 3 syntheses or guidelines pooled it, 52 citations in OpenAlex.
- Modelling approaches for predicting the distribution of skin NTDs: A systematic review.PLoS neglected tropical diseases · 2026Pooled it
- Epidemiological situation of yaws in the Americas: A systematic review in the context of a regional elimination goal.PLoS neglected tropical diseases · 2019Pooled it
- Dose and formulation of azithromycin in mass drug administration studies: a systematic review protocol.BMJ paediatrics open · 2019Pooled it
- Antibody Responses to Two Recombinant Treponemal Antigens (rp17 and TmpA) before and after Azithromycin Treatment for Yaws in Ghana and Papua New Guinea.Journal of clinical microbiology · 2021Trial
- Comparative efficacy of low-dose versus standard-dose azithromycin for patients with yaws: a randomised non-inferiority trial in Ghana and Papua New Guinea.The Lancet. Global health · 2018Trial
- External quality assessment for yaws elimination in low- and middle-income countries using plasmid-based proficiency test items.PLoS neglected tropical diseases · 2026Article
- Integrated serosurveillance of multiple communicable diseases in the hinterland of Guyana.Revista panamericana de salud publica = Pan American journal of public health · 2026Article
- Article
- Guidance for conducting and evaluating serological surveys to assess interruption of yaws transmission in the context of an eradication target.PLoS neglected tropical diseases · 2025Article
- Yaws in Africa: Past, Present and Future.Diseases (Basel, Switzerland) · 2025Review
- A Systematic Review on Suitability of Molecular Techniques for Diagnosis and Research into Infectious Diseases of Concern in Resource-Limited Settings.Current issues in molecular biology · 2022Review
- Identifying regions for enhanced control of gambiense sleeping sickness in the Democratic Republic of Congo.Nature communications · 2022Article
- Article
- Multiplex Recombinase Polymerase Amplification Assay for Simultaneous Detection ofTropical medicine and infectious disease · 2020Article
- A Loop-Mediated Isothermal Amplification Assay for the Detection ofThe American journal of tropical medicine and hygiene · 2020Article
- Factors associated with cutaneous ulcers among children in two yaws-endemic districts in Ghana.Infectious diseases of poverty · 2020Article
- Multiplex Mediator Displacement Loop-Mediated Isothermal Amplification for Detection of Treponema pallidum and Haemophilus ducreyi.Emerging infectious diseases · 2020Article
- Absence of Serological Evidence of Exposure toThe American journal of tropical medicine and hygiene · 2019Article
- Spatial-temporal clustering analysis of yaws on Lihir Island, Papua New Guinea to enhance planning and implementation of eradication programs.PLoS neglected tropical diseases · 2018Article
- Historic Treponema pallidum genomes from Colonial Mexico retrieved from archaeological remains.PLoS neglected tropical diseases · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
18 authors at 10 institutions in 9 countries.
Funding
Abstract
Yaws is endemic in west Africa, southeast Asia, and the Pacific region. To eradicate yaws by 2020, WHO has launched a campaign of mass treatment with azithromycin. Progress has been made towards achievement of this ambitious goal, including the validation of point-of-care and molecular diagnostic tests and piloting of the strategy in several countries, including Ghana, Vanuatu, and Papua New Guinea. Gaps in knowledge need to be addressed to allow refinement of the eradication strategy. Studies exploring determinants of the spatial distribution of yaws are needed to help with the completion of baseline mapping. The finding that Haemophilus ducreyi causes lesions similar to yaws is particularly important and further work is needed to assess the effect of azithromycin on these lesions. The integration of diagnostic tests into different stages of the eradication campaign needs investigation. Finally, studies must be done to inform the optimum mass-treatment strategy for sustainable interruption of transmission.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.