ArticleJournal of autism and developmental disorders2016
Relationship of the Acoustic Startle Response and Its Modulation to Emotional and Behavioral Problems in Typical Development Children and Those with Autism Spectrum Disorders.
Article in Journal of autism and developmental disorders, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 46 citations in OpenAlex.
- Neurobehavioral Assessment of Sensorimotor Function in Autism Using Smartphone Technology.Autism research : official journal of the International Society for Autism Research · 2026Article
- Startle response and its prepulse modification in health and under different psychopathologies: Could we find any specific patterns?World journal of psychiatry · 2025Review
- Developmental Disturbances in Animal Models of Autism Spectrum Disorder.Developmental neurobiology · 2025Review
- Reduced multiscale complexity of daily behavioral dynamics in autism spectrum disorder.PCN reports : psychiatry and clinical neurosciences · 2024Article
- How auditory processing influences the autistic profile: A review.Autism research : official journal of the International Society for Autism Research · 2024Review
- A handbook forFrontiers in psychology · 2024Article
- Sensory Gating in Neurodevelopmental Disorders: A Scoping Review.Research on child and adolescent psychopathology · 2023Article
- A multidimensional investigation of the relationship between skin-mediated somatosensory signals, emotion regulation and behavior problems in autistic children.Frontiers in neuroscience · 2023Article
- Hemispheres of Influence: Bridging the Disconnect between Environmental Neurotoxicology and Clinical Practice.Environmental health perspectives · 2022Article
- cacna2d3, a voltage-gated calcium channel subunit, functions in vertebrate habituation learning and the startle sensitivity threshold.PloS one · 2022Article
- Neural Markers of Auditory Response and Habituation in Phelan-McDermid Syndrome.Frontiers in neuroscience · 2022Article
- Rhythmic Relating: Bidirectional Support for Social Timing in Autism Therapies.Frontiers in psychology · 2022Article
- GABAFrontiers in integrative neuroscience · 2021Article
- Sensory filtering disruption caused by poly I:C - Timing of exposure and other experimental considerations.Brain, behavior, & immunity - health · 2020Article
- Relationship of the Acoustic Startle Response and Its Modulation to Adaptive and Maladaptive Behaviors in Typically Developing Children and Those With Autism Spectrum Disorders: A Pilot Study.Frontiers in human neuroscience · 2019Article
- Altered Auditory Processing, Filtering, and Reactivity in theThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Embryonic stem cell transplants as a therapeutic strategy in a rodent model of autism.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2018Article
- Critical reappraisal of mechanistic links of copy number variants to dimensional constructs of neuropsychiatric disorders in mouse models.Psychiatry and clinical neurosciences · 2018Review
- A Cyfip2-Dependent Excitatory Interneuron Pathway Establishes the Innate Startle Threshold.Cell reports · 2018Article
- Relationship between physiological and parent-observed auditory over-responsiveness in children with typical development and those with autism spectrum disorders.Autism : the international journal of research and practice · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Auditory hyper-reactivity is a common sensory-perceptual abnormality in autism spectrum disorders (ASD), which interrupts behavioral adaptation. We investigated acoustic startle response (ASR) modulations in 17 children with ASD and 27 with typical development (TD). Compared to TD, children with ASD had larger ASR magnitude to weak stimuli and more prolonged peak startle-latency. We could not find significant difference of prepulse inhibition (PPI) or habituation in ASD children compared to TD. However, habituation and PPI at 70-dB prepulses were negatively related to several subscales of Social Responsiveness Scale and the Strengths and Difficulties Questionnaire, when considering all children. Comprehensive investigation of ASR and its modulation might increase understanding of the neurophysiological impairments underlying ASD and other mental health problems in children.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.