ArticleBMC complementary and alternative medicine2015
Effect of hydroalcoholic leaves extract of Indigofera spicata Forssk. on blood glucose level of normal, glucose loaded and diabetic rodents.
Article in BMC complementary and alternative medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 39 citations in OpenAlex.
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- Pharmacological evaluation of medicinal plants with antidiabetic activities in Ethiopia: A review.Metabolism open · 2022Review
- Evaluation of the Antidiabetic Activity of Hydromethanolic Roots Extracts ofEvidence-based complementary and alternative medicine : eCAM · 2022Article
- Evaluation of in vivo Antidiabetic, Antidyslipidemic and in vitro Anti-Oxidant Activity of Extract and Solvent Fractions ofJournal of experimental pharmacology · 2022Article
- High anti-inflammatory and antidiabetic activities ofJournal of diabetes and metabolic disorders · 2021Article
- Evaluation of Antidiabetic and Antioxidant Activity of Leaf Extract and Solvent Fractions ofJournal of experimental pharmacology · 2021Article
- Medicinal Plant Extracts EvaluatedEvidence-based complementary and alternative medicine : eCAM · 2021Review
- Hypoglycemic, Anti-Hyperglycemic and Anti-Hyperlipidemic Effects ofJournal of experimental pharmacology · 2020Article
- Evaluation of in vitro and in vivo Anti-Diabetic, Anti-Hyperlipidemic and Anti-Oxidant Activity of Flower Crude Extract and Solvent Fractions ofJournal of experimental pharmacology · 2020Article
- Antidiabetic Activity of Extracts ofJournal of experimental pharmacology · 2020Article
- Evaluation of the antidiabetic property of aqueous leaves extract ofJournal of traditional and complementary medicine · 2018Article
- Antiplasmodial activity of Indigofera spicata root extract against Plasmodium berghei infection in mice.Malaria journal · 2017Article
- Antidiabetic and hypolipidemic activities of hydroethanolic root extract of Uvaria chamae in streptozotocin induced diabetic albino rats.BMC complementary and alternative medicine · 2016Article
- Antidiarrheal activity of crude methanolic root extract of Idigofera spicata Forssk.(Fabaceae).BMC complementary and alternative medicine · 2016Article
- Antiobesity and Antidiabetes Effects of a Cudrania tricuspidata Hydrophilic Extract Presenting PTP1B Inhibitory Potential.BioMed research international · 2016Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDiabetes mellitus is found in all parts of the world and is rapidly increasing in its coverage with alarming rate especially in Asia and Africa. Research is increasingly done with the aim of developing a relatively safe and efficacious anti-diabetic plant based products. Parallelly, this investigation was carried out to evaluate the effect of the hydro alcoholic leaves crude extract of Indigofera spicata (ISP) on the blood glucose level(BGL) of normoglycemic, oral glucose loaded and alloxan induced diabetic rodents.
methodsThe animals were randomly divided into five groups (n = 6) for all the aforementioned three models. In all models, group-I mice provided 2%tween-80, group-II were treated with 5 mg/kg glibenclamide and the remaining three groups (III, IV & V) were treated with 100, 200, and 400 mg/kg dose of the extract respectively. Statistical significance of differences in BGLs within and between groups was analyzed by SPSS version-21 using one way ANOVA followed by Tukey's post hoc multiple comparison.
result200 mg/kg and 400 mg/kg extract treated groups of normoglycemic mice showed significant (p < 0.05) BGL reduction compared to the pre-exposure level. In case of OGTT model BGL reduction was statistically significant (p < 0.05) in only 400 mg/kg exposed groups at the 120 min of post-exposure compared to the initial level. However, the BGL reducing effect of doses of the extract at the 4(th), 6(th) and 10(th) hours of post treatment on diabetic mice was found statistically significant compared to both the negative control (p < 0.001) and their respective pretreatment levels (p < 0.05).
conclusionAs it is claimed in ethnobotanical studies, the hydroalcoholic crude extract of ISP leaves have shown prominent anti-diabetic effect and can be therefore used as a good insight for new anti-diabetic drug source with a call for further studies.
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