ArticleBiomechanics and modeling in mechanobiology2016
4D subject-specific inverse modeling of the chick embryonic heart outflow tract hemodynamics.
Article in Biomechanics and modeling in mechanobiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 30 citations in OpenAlex.
- Longitudinal Live Imaging-Derived 4D Hemodynamics and Dynamic Tissue Mechanics Across Outflow Tract Morphogenesis.Annals of biomedical engineering · 2026Article
- A Parametric Finite Element Analysis of Chick Embryo Aortic Valve Leaflet Biomechanics.Bioengineering (Basel, Switzerland) · 2026Article
- Automated non-invasive laser speckle imaging of the chick heart rate and extraembryonic blood vessels and their response to Nifedipine and Amlodipine drugs.Developmental biology · 2025Article
- Modulation of mechanosensitive genes during embryonic aortic arch development.Developmental dynamics : an official publication of the American Association of Anatomists · 2025Article
- Non-invasive laser speckle contrast imaging (LSCI) of extra-embryonic blood vessels in intact avian eggs at early developmental stages.Biomedical optics express · 2024Article
- Segmentation of beating embryonic heart structures from 4-D OCT images using deep learning.Biomedical optics express · 2023Article
- OCT Meets micro-CT: A Subject-Specific Correlative Multimodal Imaging Workflow for Early Chick Heart Development Modeling.Journal of cardiovascular development and disease · 2022Article
- Mechanosensitive Pathways in Heart Development: Findings from Chick Embryo Studies.Journal of cardiovascular development and disease · 2021Review
- Computational Modeling of Blood Flow Hemodynamics for Biomechanical Investigation of Cardiac Development and Disease.Journal of cardiovascular development and disease · 2021Review
- 4-D Computational Modeling of Cardiac Outflow Tract Hemodynamics over Looping Developmental Stages in Chicken Embryos.Journal of cardiovascular development and disease · 2019Article
- Fluid dynamics in heart development: effects of hematocrit and trabeculation.Mathematical medicine and biology : a journal of the IMA · 2018Article
- Quantifying blood flow dynamics during cardiac development: demystifying computational methods.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2018Review
- Influence of blood flow on cardiac development.Progress in biophysics and molecular biology · 2018Review
- Removing vessel constriction on the embryonic heart results in changes in valve gene expression, morphology, and hemodynamics.Developmental dynamics : an official publication of the American Association of Anatomists · 2018Article
- Hemodynamics Modify Collagen Deposition in the Early Embryonic Chicken Heart Outflow Tract.Journal of cardiovascular development and disease · 2017Article
- Increased regurgitant flow causes endocardial cushion defects in an avian embryonic model of congenital heart disease.Congenital heart disease · 2017Article
- Making a heart: advances in understanding the mechanisms of cardiac development.Current opinion in pediatrics · 2016Review
- Effect of Outflow Tract Banding on Embryonic Cardiac Hemodynamics.Journal of cardiovascular development and disease · 2016Article
- Blood flow through the embryonic heart outflow tract during cardiac looping in HH13-HH18 chicken embryos.Journal of the Royal Society, Interface · 2015Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Blood flow plays a critical role in regulating embryonic cardiac growth and development, with altered flow leading to congenital heart disease. Progress in the field, however, is hindered by a lack of quantification of hemodynamic conditions in the developing heart. In this study, we present a methodology to quantify blood flow dynamics in the embryonic heart using subject-specific computational fluid dynamics (CFD) models. While the methodology is general, we focused on a model of the chick embryonic heart outflow tract (OFT), which distally connects the heart to the arterial system, and is the region of origin of many congenital cardiac defects. Using structural and Doppler velocity data collected from optical coherence tomography, we generated 4D ([Formula: see text]) embryo-specific CFD models of the heart OFT. To replicate the blood flow dynamics over time during the cardiac cycle, we developed an iterative inverse-method optimization algorithm, which determines the CFD model boundary conditions such that differences between computed velocities and measured velocities at one point within the OFT lumen are minimized. Results from our developed CFD model agree with previously measured hemodynamics in the OFT. Further, computed velocities and measured velocities differ by [Formula: see text]15 % at locations that were not used in the optimization, validating the model. The presented methodology can be used in quantifications of embryonic cardiac hemodynamics under normal and altered blood flow conditions, enabling an in-depth quantitative study of how blood flow influences cardiac development.
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