ArticlePloS one2015
Indoleamine 2,3-Dioxygenase Is Involved in the Inflammation Response of Corneal Epithelial Cells to Aspergillus fumigatus Infections.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 41 citations in OpenAlex.
- Kynurenine, Kynurenic Acid, Quinolinic Acid and Interleukin-6 Levels in the Serum of Patients with Autism Spectrum Disorder.Medicina (Kaunas, Lithuania) · 2023Article
- Indoleamine 2,3-dioxygenase adjusts neutrophils recruitment and chemotaxis inInternational journal of ophthalmology · 2022Article
- Preparation of a Nanobody Specific to Dectin 1 and Its Anti-inflammatory Effects on Fungal Keratitis.International journal of nanomedicine · 2022Article
- Immunologic mechanism of fungal keratitis.International journal of ophthalmology · 2021Review
- Indoleamine 2,3-Dioxygenase Regulates Macrophage Recruitment, Polarization and Phagocytosis in Aspergillus Fumigatus Keratitis.Investigative ophthalmology & visual science · 2020Article
- Dimethyl itaconate protects against fungal keratitis by activating the Nrf2/HO-1 signaling pathway.Immunology and cell biology · 2020Article
- Regulation of LOX-1 on adhesion molecules and neutrophil infiltration in mouseInternational journal of ophthalmology · 2020Article
- Activation of the kynurenine pathway is associated with poor outcome in Pneumocystis pneumonia patients infected with HIV: results of 2 months cohort study.BMC infectious diseases · 2019Article
- Disparate expression of autophagy in corneas of C57BL/6 mice and BALB/c mice afterInternational journal of ophthalmology · 2019Article
- HMGB1 Antagonist, Box A, Reduces TLR4, RAGE, and Inflammatory Cytokines in the Cornea of P. aeruginosa-Infected Mice.Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics · 2018Article
- Animal Models of Aspergillosis.Comparative medicine · 2018Review
- Production of interleukin-1β related to mammalian target of rapamycin/Toll-like receptor 4 signaling pathway duringInternational journal of ophthalmology · 2018Article
- Boxb mediate BALB/c mice corneal inflammation through a TLR4/MyD88-dependent signaling pathway inInternational journal of ophthalmology · 2018Article
- A Multifaceted Role of Tryptophan Metabolism and Indoleamine 2,3-Dioxygenase Activity inFrontiers in immunology · 2017Review
- Rodent Models of Invasive Aspergillosis due toFrontiers in microbiology · 2017Review
- Article
- Recent advances in diagnosis and management of Mycotic Keratitis.Indian journal of ophthalmology · 2016Review
- Review of clinical and basic approaches of fungal keratitis.International journal of ophthalmology · 2016Review
- Effects of retinoic acid receptor-γ on theInternational journal of ophthalmology · 2016Article
- Expression of indoleamine 2,3-dioxygenase in a murine model of Aspergillus fumigatus keratitis.International journal of ophthalmology · 2016Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Indoleamine 2,3-dioxygenase (IDO), which is mainly expressed in activated dendritic cells, is known as a regulator of immune responses. However, the role of IDO in immune responses against fungal corneal infection has not been investigated. To evaluate the regulatory mechanisms of IDO in fungal inflammation, we resorted to human corneal epithelial cells (HCECs), known as the first barrier of cornea against pathogenic microorganisms. We found that IDO was significantly up-regulated in corneal epithelium infected with Aspergillus fumigatus (A. fumigatus) and HCECs incubated with spores of A. fumigatus. Furthermore, IDO inhibitor (1-methyltryptophan, 1-MT) enhanced inflammatory cytokines IL-1β and IL-6 expression which were up-regulated by A. fumigatus spores infection. Dectin-1, as one of the important C-type lectin receptors, can identify β-glucan, and mediate fungal innate immune responses. In the present study, pre-treatment with curdlan, a Dectin-1 agonist, further enhanced IDO expression compared with A. fumigatus stimulation. While laminarin, the Dectin-1 specific inhibitor, partially inhibited IDO expression stimulated by A. fumigatus. Further studies demonstrated inhibition of IDO activity amplified the expressions of inflammatory cytokines IL-1β and IL-6 induced by activation of Dectin-1. These results suggested that IDO was involved in the immune responses of fungal keratitis. The activation of Dectin-1 may contribute to A. fumigatus spores-induced up-regulation of IDO.
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