ArticleAging cell2015
Inhibition of elongin C promotes longevity and protein homeostasis via HIF-1 in C. elegans.
Article in Aging cell, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 25 citations in OpenAlex.
- Functional Testing of Human Disease Missense Variants inKidney international reports · 2025Article
- Transcriptome analyses describe the consequences of persistent HIF-1 over-activation in Caenorhabditis elegans.PloS one · 2024Article
- Tyrosine aminotransferase is involved in the oxidative stress response by metabolizingThe Journal of biological chemistry · 2019Article
- KIN-4/MAST kinase promotes PTEN-mediated longevity of Caenorhabditis elegans via binding through a PDZ domain.Aging cell · 2019Article
- Emerging topics in C. elegans aging research: Transcriptional regulation, stress response and epigenetics.Mechanisms of ageing and development · 2019Review
- Prefoldin 6 mediates longevity response from heat shock factor 1 to FOXO inGenes & development · 2018Article
- Genetic inhibition of an ATP synthase subunit extends lifespan in C. elegans.Scientific reports · 2018Article
- RNA surveillance via nonsense-mediated mRNA decay is crucial for longevity in daf-2/insulin/IGF-1 mutant C. elegans.Nature communications · 2017Article
- RNAi targetingF1000Research · 2017Article
- OASIS 2: online application for survival analysis 2 with features for the analysis of maximal lifespan and healthspan in aging research.Oncotarget · 2016Article
- Atlas on substrate recognition subunits of CRL2 E3 ligases.Oncotarget · 2016Review
- RNA helicase SACY-1 is required for longevity caused by various genetic perturbations in Caenorhabditis elegans.Cell cycle (Georgetown, Tex.) · 2016Article
- Inverse correlation between longevity and developmental rate among wild C. elegans strains.Aging · 2016Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The transcription factor hypoxia-inducible factor 1 (HIF-1) is crucial for responses to low oxygen and promotes longevity in Caenorhabditis elegans. We previously performed a genomewide RNA interference screen and identified many genes that act as potential negative regulators of HIF-1. Here, we functionally characterized these genes and found several novel genes that affected lifespan. The worm ortholog of elongin C, elc-1, encodes a subunit of E3 ligase and transcription elongation factor. We found that knockdown of elc-1 prolonged lifespan and delayed paralysis caused by impaired protein homeostasis. We further showed that elc-1 RNA interference increased lifespan and protein homeostasis by upregulating HIF-1. The roles of elongin C and HIF-1 are well conserved in eukaryotes. Thus, our study may provide insights into the aging regulatory pathway consisting of elongin C and HIF-1 in complex metazoans.
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