Evidence map›Paper›PMID 26360794›Full record

ArticlePLoS neglected tropical diseases2015

Molecular Characterization of Staphylococcus aureus Isolates Transmitted between Patients with Buruli Ulcer.

Nana Ama Amissah, Monika A Chlebowicz, Anthony Ablordey, Artur J Sabat, Caitlin S Tetteh, Isaac Prah, Tjip S van der Werf, Alex W Friedrich, Jan Maarten van Dijl, John W Rossen and 1 more

Open access · goldAbstract read
In one paragraph

Article in PLoS neglected tropical diseases, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Molecular Characterization ofMicroorganisms · 2020
    Article
  6. Pharmacologic management ofExpert review of clinical pharmacology · 2020
    Review
  7. Article
  8. Methicillin ResistantFrontiers in microbiology · 2017
    Article
  9. Article
  10. Molecular epidemiology of Staphylococcus aureus from Lambaréné, Gabon.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2016
    Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 2 countries.

Nana Ama AmissahDepartment of Internal Medicine/Infectious Diseases, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands; Department of Bacteriology, Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, Ghana.
Monika A ChlebowiczDepartment of Medical Microbiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Anthony AblordeyDepartment of Bacteriology, Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, Ghana.
Artur J SabatDepartment of Medical Microbiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Caitlin S TettehDepartment of Bacteriology, Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, Ghana.
Isaac PrahDepartment of Bacteriology, Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, Ghana.
Tjip S van der WerfDepartment of Internal Medicine/Infectious Diseases, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Alex W FriedrichDepartment of Medical Microbiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Jan Maarten van DijlDepartment of Medical Microbiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
John W RossenDepartment of Medical Microbiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Ymkje StienstraDepartment of Internal Medicine/Infectious Diseases, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
University Medical Center Groningen · NLUniversity of Groningen · NLNoguchi Memorial Institute for Medical Research · GHUniversity of Ghana · GH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundBuruli ulcer (BU) is a skin infection caused by Mycobacterium ulcerans. The wounds of most BU patients are colonized with different microorganisms, including Staphylococcus aureus. METHODOLOGY: This study investigated possible patient-to-patient transmission events of S. aureus during wound care in a health care center. S. aureus isolates from different BU patients with overlapping visits to the clinic were whole-genome sequenced and analyzed by a gene-by-gene approach using SeqSphere(+) software. In addition, sequence data were screened for the presence of genes that conferred antibiotic resistance. PRINCIPAL

findingsSeqSphere(+) analysis of whole-genome sequence data confirmed transmission of methicillin resistant S. aureus (MRSA) and methicillin susceptible S. aureus among patients that took place during wound care. Interestingly, our sequence data show that the investigated MRSA isolates carry a novel allele of the fexB gene conferring chloramphenicol resistance, which had thus far not been observed in S. aureus.

Indexed as

Genetic VariationAdultBuruli UlcerCarrier StateChildChild, PreschoolCross InfectionDNA, BacterialDrug Resistance, BacterialGenotypeHealth FacilitiesHumansMolecular EpidemiologyMolecular Sequence DataSequence Analysis, DNAStaphylococcal InfectionsDNA, Bacterial

Identifiers

PMID26360794
PMCPMC4567303
OpenAlexW2253190072

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.