Evidence map›Paper›PMID 26360770›Full record

Trial reportPsychoneuroendocrinology2015

Trait sensitivity to social disconnection enhances pro-inflammatory responses to a randomized controlled trial of endotoxin.

Mona Moieni, Michael R Irwin, Ivana Jevtic, Elizabeth C Breen, Hyong Jin Cho, Jesusa M G Arevalo, Jeffrey Ma, Steven W Cole, Naomi I Eisenberger

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Psychoneuroendocrinology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01671150 (Inflammation-Induced Depressed Mood), which is not on this map. Cited by 35 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01671150 early_phase1completednot on this map

Inflammation-Induced Depressed Mood: The Role of Social Neurocognitive Mechanisms

TypeinterventionalSponsorUniversity of California, Los AngelesRan2011 to 2013Enrolled100ConditionsDepressionArmsendotoxin
3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Trial
  4. Trial
  5. Trial
  6. Trial
  7. Moderators for depressed mood and systemic and transcriptional inflammatory responses: a randomized controlled trial of endotoxin.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2019
    Trial
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Impact of the COVID-19 pandemic on inflammatory bowel disease: The role of emotional stress and social isolation.Stress and health : journal of the International Society for the Investigation of Stress · 2022
    Article
  17. Article
  18. Review
  19. Article
  20. Loneliness: An Immunometabolic Syndrome.International journal of environmental research and public health · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Mona MoieniDepartment of Psychology, University of California, Los Angeles, CA 90095, United States.
Michael R IrwinSemel Institute for Neuroscience and Human Behavior, Cousins Center for Psychoneuroimmunology, University of California, Los Angeles, CA 90095, United States.
Ivana JevticDepartment of Psychology, University of California, Los Angeles, CA 90095, United States.
Elizabeth C BreenSemel Institute for Neuroscience and Human Behavior, Cousins Center for Psychoneuroimmunology, University of California, Los Angeles, CA 90095, United States.
Hyong Jin ChoSemel Institute for Neuroscience and Human Behavior, Cousins Center for Psychoneuroimmunology, University of California, Los Angeles, CA 90095, United States.
Jesusa M G ArevaloDepartment of Medicine, Division of Hematology-Oncology, and Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, CA 90095, United States.
Jeffrey MaDepartment of Medicine, Division of Hematology-Oncology, and Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, CA 90095, United States.
Steven W ColeDepartment of Medicine, Division of Hematology-Oncology, and Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, CA 90095, United States. Electronic address: steve.cole@ucla.edu.
Naomi I EisenbergerDepartment of Psychology, University of California, Los Angeles, CA 90095, United States. Electronic address: neisenbe@ucla.edu.

Funding

UCLA Clinical and Translational Science InstituteUL1TR000124 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUBINETT, STEVEN M. · 2012 to 2015
$57.0M
USC/UCLA Center on Biodemography &Population HealthP30AG017265 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI JENNIFER A AILSHIRE · 1999 to 2026
$17.9M
UCLA OLDER AMERICANS INDEPENDENCE CENTERP30AG028748 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MOORE, ALISON AHERN · 2006 to 2017
$9.8M
Aging: Sleep and Inflammatory Mechanisms in Depression PreventionR01AG026364 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI IRWIN, MICHAEL R · 2005 to 2015
$5.8M
Sleep, Inflamation, and Depression Occurrence in Breast Cancer SurvivorsR01CA160245 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI IRWIN, MICHAEL R · 2012 to 2016
$3.9M
Chronic Moderate Sleep Restriction in Older Long and Older Average SleepersR01HL095799 · NHLBI · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI IRWIN, MICHAEL R, JEAN-LOUIS, GIRARDIN · 2011 to 2015
$3.8M
Social Regulation of Gene Expression, SupplementR37AG033590 · NIA · UNIVERSITY OF CHICAGO · PI CACIOPPO, JOHN T. · 2010 to 2017
$3.5M
Mechanisms of Sleep Disruption HyperalgesiaR01DA032922 · NIDA · JOHNS HOPKINS UNIVERSITY · PI IRWIN, MICHAEL R, SMITH, MICHAEL T · 2012 to 2016
$2.7M
Tai Chi Effects on Chronic Insomnia in Breast Cancer Survivors: Immune MechanismsR01CA119159 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI IRWIN, MICHAEL R · 2006 to 2010
$2.2M
Subjective Social Isolation and Sleep Disturbances: Inflammatory Mechanisms in AgR01AG034588 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI IRWIN, MICHAEL R · 2009 to 2013
$1.9M
Inflammation-Induced Depressed Mood: The Role of Social Neurocognitive MechanismsR01MH091352 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI EISENBERGER, NAOMI ILANA · 2010 to 2013
$1.7M
Social regulation of pro-inflammatory monocytesR01AG043404 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI COLE, STEVE W · 2014 to 2018
$1.6M
NCATS NIH HHS UL1 TR000124NCATS NIH HHS UL1TR000124NCI NIH HHS R01 CA119159NCI NIH HHS R01CA119159NCI NIH HHS R01 CA160245NCI NIH HHS R01CA160245-01NHLBI NIH HHS R01 HL095799NHLBI NIH HHS R01HL095799NIA NIH HHS 1F31AG048668NIA NIH HHS F31 AG048668NIA NIH HHS K23 AG049085NIA NIH HHS P30 AG017265NIA NIH HHS P30AG017265NIA NIH HHS P30 AG028748NIA NIH HHS P30AG028748NIA NIH HHS R01 AG026364NIA NIH HHS R01AG026364NIA NIH HHS R01 AG033590NIA NIH HHS R01AG033590NIA NIH HHS R01 AG034588NIA NIH HHS R01AG034588NIA NIH HHS R01 AG043404NIA NIH HHS R01AG043404NIA NIH HHS R37 AG033590NIDA NIH HHS R01 DA032922NIDA NIH HHS R01DA032922-01NIGMS NIH HHS 5T32GM084903NIGMS NIH HHS T32 GM084903NIMH NIH HHS 5R01MH091352NIMH NIH HHS R01 MH091352
6 · The paper itself

Abstract

unlabelledOne proposed mechanism for the association between social isolation and poor health outcomes is inflammation. Lonely or socially disconnected individuals show greater inflammatory responses, including up-regulation of pro-inflammatory gene expression, and people who are sensitive to cues of social disconnection (e.g., high levels of anxious attachment) exhibit greater inflammation in response to psychological stress. However, no studies have examined how sensitivity to social disconnection may influence pro-inflammatory responses to an inflammatory challenge. In the present study, we investigated the impact of sensitivity to social disconnection (a composite score comprised of loneliness, anxious attachment, fear of negative evaluation, and rejection sensitivity) on pro-inflammatory cytokines and gene expression in response to endotoxin, an inflammatory challenge, vs. placebo in a sample of one hundred and fifteen (n=115) healthy participants. Results showed that those who are more sensitive to social disconnection show increased pro-inflammatory responses (i.e., increased levels of tumor necrosis factor-alpha and interleukin-6) to endotoxin, as well as up-regulation of multiple genes related to inflammation. Furthermore, bioinformatics analyses revealed that those in the endotoxin group who are more sensitive to social disconnection exhibited a conserved transcriptional response to adversity (CTRA) regulatory profile, involving up-regulation of beta-adrenergic and pro-inflammatory transcription control pathways and down-regulation of antiviral transcription factors in response to endotoxin. These results may ultimately have implications for understanding the links between social isolation, inflammation, and health. CLINICAL TRIALS REGISTRATION: ClinicalTrials.gov NCT01671150.

Indexed as

PersonalitySocial IsolationAdolescentAdultDouble-Blind MethodEndotoxinsFemaleHumansInflammationInterleukin-6LonelinessMaleTumor Necrosis Factor-alphaYoung AdultEndotoxinsIL6 protein, humanInterleukin-6Tumor Necrosis Factor-alphaCytokinesEndotoxinInflammationLonelinessRejection sensitivitySocial genomics

Identifiers

PMID26360770
PMCPMC4637264

What OpenQuestion holds

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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.