ArticleThe West Indian medical journal2015
Upper Gastrointestinal Bleeding in Children: The Role of Helicobacter pylori Infection and Non-steroidal Anti-inflammatory Drug Use.
Article in The West Indian medical journal, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 9 citations in OpenAlex.
- Temporal trends and correlates of Helicobacter pylori prevalence in children undergoing upper gastrointestinal endoscopy.European journal of pediatrics · 2026Article
- Article
- Gastroprotective Efficacy of North African Medicinal Plants: A Review on Their Therapeutic Potential for Peptic Ulcers.Food science & nutrition · 2024Review
- Trends in Upper Gastrointestinal Bleeding in Children: The Impact ofAntibiotics (Basel, Switzerland) · 2024Article
- Current status and future challenges in the endoscopic management of non-variceal upper gastrointestinal bleeding in children.Pediatric surgery international · 2020Article
- Working Towards an Appropriate Use of Ibuprofen in Children: An Evidence-Based Appraisal.Drugs · 2017Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo study the role of non-steroidal anti-inflammatory drugs (NSAIDs) and Helicobacter pylori infection in the aetiology of upper gastrointestinal bleeding (UGIB) in children. SUBJECTS AND
methodsOne hundred and eighty-eight patients (82 girls, 106 boys; mean age 8.43 ± 5.24 years), admitted to the paediatric gastroenterology unit because of UGIB and who underwent endoscopic examination, were studied from their medical records, retrospectively.
resultsUpper gastrointestinal bleeding was observed in 188 (8.29%) of 2266 patients. The mucosal causes related to the oesophagus, stomach and duodenum were found at the rate of 37%, 58% and 24.5%, respectively with endoscopic examination. The location of bleeding could not be determined in 14.4% of the patients. History of drug intake before admitting to hospital was present in 40 patients (21.3%). When we examined these forty patients, 35% were on acetylsalicylic acid, 47.5% were on ibuprofen and 17.5% were on NSAIDs. Ibuprofen versus acetylsalicylic acid usage was found to be highly significant (p < 0.05) for UGIB. Helicobacter pylori was found in 20.7% of the patients. The relationship between H pylori and UGIB was not found statistically significant (p > 0.05). The relationship between drug intake and presence of H pylori infection was not found significant in our patients (p > 0.05).
conclusionIbuprofen and acetylsalicylic acid intake were found significant in the aetiology of UGIB in children. There was no significant connection with Helicobacter pylori infection in children with UGIB. We did not find a significant relationship with drug intake and H pylori infection.
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Registered trials
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