ArticleThe lancet. Psychiatry2015
Staging bipolar disorder: what data and what models are needed?
Article in The lancet. Psychiatry, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Allostatic and Circadian Drives in Patients with Bipolar Disorder in Depressive Episodes or with Post-Traumatic Stress Disorder Versus Healthy Controls: Neuroendocrine Comparison Through Cortisol and 6-Sulfatoxymelatonin Overnight Urine Excretion.International journal of molecular sciences · 2026Article
- Putative Risk Biomarkers of Bipolar Disorder in At-risk Youth.Neuroscience bulletin · 2024Review
- Heterogeneous early illness courses of Korean patients with bipolar disorders: replication of the staging model.BMC psychiatry · 2022Article
- Early Diagnosis of Bipolar Disorder Coming Soon: Application of an Oxidative Stress Injury Biomarker (BIOS) Model.Neuroscience bulletin · 2022Article
- Improving the Assessment Process of Family Functioning in Adult Bipolar Disorders: A PRISMA Systematic Review.Journal of clinical medicine · 2022Review
- Daily estimates of clinical severity of symptoms in bipolar disorder from smartphone-based self-assessments.Translational psychiatry · 2020Article
- Does stage of illness influence recovery-focused outcomes after psychological treatment in bipolar disorder? A systematic review protocol.Systematic reviews · 2019Article
- Smartphone-based self-monitoring in bipolar disorder: evaluation of usability and feasibility of two systems.International journal of bipolar disorders · 2019Article
- The Staging of Major Mood Disorders: Clinical and Neurobiological Correlates.Psychiatry investigation · 2018Article
- Allostatic load but not medical burden predicts memory performance in late-life bipolar disorder.International journal of geriatric psychiatry · 2018Review
- Smartphone-based objective monitoring in bipolar disorder: status and considerations.International journal of bipolar disorders · 2018Review
- Dysregulation of glucose metabolism since young adulthood increases the risk of cardiovascular diseases in patients with bipolar disorder.The Kaohsiung journal of medical sciences · 2017Article
- Systemic challenges in bipolar disorder management: A patient-centered approach.Bipolar disorders · 2017Article
- Systems Chronotherapeutics.Pharmacological reviews · 2017Review
- Is There a Bipolar Prodrome Among Children and Adolescents?Current psychiatry reports · 2016Article
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3 authors.
Funding
Abstract
Although bipolar disorder is increasingly recognised as a spectrum of multisystem disorders (ie, bipolar disorders), proposed staging models and theories of bipolar disease progression often fail to incorporate longitudinal data or data from multiple domains of dysfunction. We propose that bipolar disorders are best thought of as syndromes, with different trajectories of development and progression for various symptoms and demographic groups. This inherent complexity might be better suited to non-traditional modelling techniques, potentially derived from chaos theory. In this Personal View, we propose an allostatic load framework to account for biomarkers of physiological symptom progression. We then suggest integration of two potential domains of biobehavioural markers: sleep and wake and circadian rhythm regulation and the behavioural activation system. A satisfactory model should account for the effects of developmental stage as well as demographic characteristics, including but not limited to sex, culture, ethnicity, and socioeconomic status. The ultimate goal of a staging model has to be to inform the development of targeted, stage-appropriate interventions to reduce the substantial burden of bipolar disorders on individuals and societies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.