ArticleAddiction (Abingdon, England)2016
Drinking and mortality: long-term follow-up of drinking-discordant twin pairs.
Article in Addiction (Abingdon, England), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it, 60 citations in OpenAlex.
- Are there non-linear relationships between alcohol consumption and long-term health?: a systematic review of observational studies employing approaches to improve causal inference.BMC medical research methodology · 2022Pooled it
- The Drinking Dashboard for alcohol-induced blackout: A randomized pilot trial.Alcohol, clinical & experimental research · 2025Trial
- Benefits and Risks of Moderate Alcohol Consumption on Cardiovascular Disease: Current Findings and Controversies.Nutrients · 2019Trial
- Reduced central alpha power at rest is associated with the risk of alcohol-induced blackout and frequency of non-REM parasomnia episodes in adults.Physiological reports · 2026Article
- Sex differences in blackout: evidence of a relationship between disorders of arousal during sleep and alcohol-related blackout in females.Frontiers in psychology · 2026Review
- Protein Associations With Alcohol Consumption and Genetic Risk for Alcohol-Related Sociomedical Conditions.Addiction biology · 2025Article
- Health characteristics and health behaviours in male former contact sports participants: comparison with general population controls in a Finnish cohort study.Journal of epidemiology and community health · 2025Article
- Associations between posting about alcohol on social networking sites and alcohol-induced blackouts in a sample of young adults not in 4-year college.Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors · 2025Article
- The associations of long-term physical activity in adulthood with later biological ageing and all-cause mortality - a prospective twin study.European journal of epidemiology · 2025Article
- Lifestyle differences between co-twins are associated with decreased similarity in their internal and external exposome profiles.Scientific reports · 2024Article
- Nightmares share genetic risk factors with sleep and psychiatric traits.Translational psychiatry · 2024Article
- Dementia risk factors in former contact sports participants: prospective cohort study.medRxiv : the preprint server for health sciences · 2024Article
- Lifestyle differences between co-twins are associated with decreased similarity in their internal and external exposome profiles.medRxiv : the preprint server for health sciences · 2023Article
- Associations between Liver Enzymes, Lifestyle Risk Factors and Pre-Existing Medical Conditions in a Population-Based Cross-Sectional Sample.Journal of clinical medicine · 2023Article
- Paternal and Maternal Problem Drinking and Lifetime Problem Drinking of Their Adult Children.Twin research and human genetics : the official journal of the International Society for Twin Studies · 2023Article
- Examining Attitude, Norms, and Intentions as Predictors of Prospective Change in Alcohol-Induced Blackouts.Journal of studies on alcohol and drugs · 2023Article
- Impact of Physical Activity on the Characteristics and Metabolic Consequences of Alcohol Consumption: A Cross-Sectional Population-Based Study.International journal of environmental research and public health · 2022Article
- Alcohol Drinking Patterns and Laboratory Indices of Health: Does Type of Alcohol Preferred Make a Difference?Nutrients · 2022Article
- Blood and skeletal muscle ageing determined by epigenetic clocks and their associations with physical activity and functioning.Clinical epigenetics · 2021Article
- Unmet Healthcare Needs and Associated Factors in Rural and Suburban Vietnam: A Cross-Sectional Study.International journal of environmental research and public health · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
aimsTo determine if associations of alcohol consumption with all-cause mortality replicate in discordant monozygotic twin comparisons that control for familial and genetic confounds.
designA 30-year prospective follow-up.
settingPopulation-based older Finnish twin cohort.
participantsSame-sex twins, aged 24-60 years at the end of 1981, without overt comorbidities, completed questionnaires in 1975 and 1981 with response rates of 89 and 84%. A total of 15,607 twins were available for mortality follow-up from the date of returned 1981 questionnaires to 31 December 2011; 14,787 twins with complete information were analysed. MEASUREMENTS: Self-reported monthly alcohol consumption, heavy drinking occasions (HDO) and alcohol-induced blackouts. Adjustments for age, gender, marital and smoking status, physical activity, obesity, education and social class.
findingsAmong twins as individuals, high levels of monthly alcohol consumption (≥ 259 g/month) associated with earlier mortality [hazard ratio (HR) = 1.63, 95% confidence interval (CI) = 1.47-1.81]. That association was replicated in comparisons of all informatively drinking-discordant twin pairs (HR = 1.91, 95% CI = 1.49-2.45) and within discordant monozygotic (MZ) twin pairs (HR = 2.24, 95% CI = 1.31-3.85), with comparable effect size. Smaller samples of MZ twins discordant for HDO and blackouts limited power; a significant association with mortality was found for multiple blackouts (HR = 2.82, 95% CI = 1.30-6.08), but not for HDO.
conclusionsThe associations of high levels of monthly alcohol consumption and alcohol-induced blackouts with increased all-cause mortality among Finnish twins cannot be explained by familial or genetic confounds; the explanation appears to be causal.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.