Evidence map›Paper›PMID 26359528›Full record

ArticleNeurobiology of aging2015

Genetic variants associated with susceptibility to psychosis in late-onset Alzheimer's disease families.

Sandra Barral, Badri N Vardarajan, Dolly Reyes-Dumeyer, Kelley M Faber, Thomas D Bird, Debby Tsuang, David A Bennett, Roger Rosenberg, Bradley F Boeve, Neill R Graff-Radford and 14 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurobiology of aging, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
1.7field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Genetics of psychosis of Alzheimer disease.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2017
    Review
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors at 13 institutions in 2 countries.

Sandra BarralTaub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Medical Center and New York Presbyterian Hospital, New York, NY, USA; Gertrude H. Sergievsky Center, Columbia University Medical Center and New York Presbyterian Hospital, New York, NY, USA; Department of Neurology, Columbia University Medical Center and New York Presbyterian Hospital, New York, NY, USA.
Badri N VardarajanTaub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Medical Center and New York Presbyterian Hospital, New York, NY, USA; Gertrude H. Sergievsky Center, Columbia University Medical Center and New York Presbyterian Hospital, New York, NY, USA; Department of Neurology, Columbia University Medical Center and New York Presbyterian Hospital, New York, NY, USA.
Dolly Reyes-DumeyerTaub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Medical Center and New York Presbyterian Hospital, New York, NY, USA; Gertrude H. Sergievsky Center, Columbia University Medical Center and New York Presbyterian Hospital, New York, NY, USA; Department of Neurology, Columbia University Medical Center and New York Presbyterian Hospital, New York, NY, USA.
Kelley M FaberDepartment of Medical and Molecular Genetics, Indiana University, Indianapolis, IN, USA.
Thomas D BirdDepartment of Neurology, University of Washington, Seattle, WA, USA; Department of Medicine, University of Washington, Seattle, WA, USA.
Debby TsuangDepartment of Neurology, University of Washington, Seattle, WA, USA; Department of Medicine, University of Washington, Seattle, WA, USA.
David A BennettRush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA.
Roger RosenbergDepartment of Neurology and Neurotherapeutics, The University of Texas Southwestern Medical Center, Dallas, TX, USA.
Bradley F BoeveDepartment of Neurology, Mayo Clinic, Rochester, MN, USA.
Neill R Graff-RadfordDepartment of Neurology, Mayo Clinic, Jacksonville, FL, USA.
Alison M GoateIcanhn School of Medicine at Mount Sinai, New York, NY, USA.
Martin FarlowDepartment of Neurology, Indiana University Center for Alzheimer's Disease and Related Disorders, Indianapolis, IN, USA.
Rafael LantiguaTaub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Medical Center and New York Presbyterian Hospital, New York, NY, USA; Department of Medicine, Columbia University Medical Center and New York Presbyterian Hospital, New York, NY, USA.
Martin Z MedranoDepartment of Geriatrics, Pontificia Universidad Católica Madre y Maestra, Santiago, Dominican Republic.
Xinbing WangDepartment of Human Genetics, University of Pittsburgh, Pittsburgh, PA, USA; Department of Biostatistics, University of Pittsburgh, Pittsburgh, PA, USA.
M Ilyas KambohDepartment of Human Genetics, University of Pittsburgh, Pittsburgh, PA, USA.
Mahmud Muhiedine BarmadaDepartment of Human Genetics, University of Pittsburgh, Pittsburgh, PA, USA.
Daniel J SchaidDepartment of Health Sciences Research, Mayo Clinic, Rochester, MN, USA.
Tatiana M ForoudDepartment of Medical and Molecular Genetics, Indiana University, Indianapolis, IN, USA.
Elise A WeamerDepartment of Neurology, University of Pittsburgh, Pittsburgh, PA, USA.
Ruth OttmanGertrude H. Sergievsky Center, Columbia University Medical Center and New York Presbyterian Hospital, New York, NY, USA; Department of Neurology, Columbia University Medical Center and New York Presbyterian Hospital, New York, NY, USA; Department of Epidemiology, Columbia University Medical Center and New York Presbyterian Hospital, New York, NY, USA; Division of Epidemiology, New York State Psychiatric Institute, New York, NY, USA.
Robert A SweetDepartment of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA; VISN 4 Mental Illness Research, Education and Clinical Center (MIRECC), VA Pittsburgh Healthcare System, Pittsburgh, PA, USA.
Richard MayeuxTaub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Medical Center and New York Presbyterian Hospital, New York, NY, USA; Gertrude H. Sergievsky Center, Columbia University Medical Center and New York Presbyterian Hospital, New York, NY, USA; Department of Neurology, Columbia University Medical Center and New York Presbyterian Hospital, New York, NY, USA. Electronic address: rpm2@cumc.columbia.edu.
NIA-LOAD/NCRAD Family Study Group
NewYork–Presbyterian Hospital · USUniversity of Pittsburgh · USIndiana University – Purdue University Indianapolis · USColumbia University Irving Medical Center · USUniversity of Washington · USIcahn School of Medicine at Mount Sinai · USMayo Clinic in Arizona · USMayo Clinic in Florida · USPontificia Universidad Católica Madre y Maestra · DORush University Medical Center · USThe University of Texas Southwestern Medical Center · USVA Pittsburgh Healthcare System · USWinnMed · US

Funding

National Centralized Repository for Alzheimer's Disease and Related Dementias (NCRAD)U24AG021886 · NIA · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI TATIANA M. FOROUD · 2002 to 2026
$119.8M
THERAPEUTIC EFFECTS OF INTRA-NASAL INSULIN DETEMIRP50AG005136 · NIA · UNIVERSITY OF WASHINGTON · PI JAYADEY, SUMAN · 1985 to 2019
$57.2M
TREATMENT OF DEPRESSION IN ALZHEIMER'S DISEASEP50AG005133 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KOFLER, JULIA K · 1985 to 2019
$43.0M
The National Institute on Aging (NIA) Late Onset of Alzheimer's Disease (LOAD) Family-Based Study (FBS)U24AG056270 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Gary Wayne Beecham, TATIANA M. FOROUD · 2017 to 2026
$31.4M
Quality Assurance and Quality Control Project Management: Improving Submissions and Study Conduct in the Human Subjects Research Prior Approval ProcessUL1TR002529 · NCATS · INDIANA UNIVERSITY INDIANAPOLIS · PI MOE, SHARON M, WIEHE, SARAH ELIZABETH · 2018 to 2022
$27.2M
Indiana Clinical and Translational Sciences InstituteUL1TR001108 · NCATS · INDIANA UNIVERSITY INDIANAPOLIS · PI DENNE, SCOTT C., SHEKHAR, ANANTHA · 2013 to 2017
$23.3M
Prediction of Psychosis in Alzheimer DiseaseR01AG027224 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI SWEET, ROBERT A · 2007 to 2021
$10.8M
Genetic Epidemiology of Alzheimer's Disease in HispanicsR37AG015473 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MAYEUX, RICHARD P · 2004 to 2013
$10.8M
Genetic Consortium for Late Onset Alzheimer's DiseaseU24AG026395 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MAYEUX, RICHARD P · 2005 to 2009
$10.1M
Search for the Alzheimers GenesR01AG030653 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KAMBOH, M. ILYAS · 2009 to 2019
$7.7M
Epidemiology of Familial Late-Onset Alzheimer's DiseaseR01AG041797 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MAYEUX, RICHARD P · 2012 to 2016
$4.2M
Genetic Studies of Alzheimer's Disease in Caribbean HispanicsRF1AG015473 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MAYEUX, RICHARD P · 2015 to 2018
$3.3M
CSRD VA I01 CX001006NCATS NIH HHS UL1 TR001108NIA NIH HHS AG005133NIA NIH HHS AG027224NIA NIH HHS AG030653NIA NIH HHS AG041718NIA NIH HHS P50 AG005133NIA NIH HHS P50 AG005136NIA NIH HHS R01 AG027224NIA NIH HHS R01 AG030653NIA NIH HHS R01 AG041718NIA NIH HHS R01 AG041797NIA NIH HHS R01AG041797NIA NIH HHS R37 AG015473NIA NIH HHS R37AG015473NIA NIH HHS RF1 AG015473NIA NIH HHS U24 AG021886NIA NIH HHS U24 AG026395NIA NIH HHS U24AG026395NIA NIH HHS U24 AG056270NIA NIH HHS U24AG21886
6 · The paper itself

Abstract

Psychotic symptoms are frequent in late-onset Alzheimer's disease (LOAD) patients. Although the risk for psychosis in LOAD is genetically mediated, no genes have been identified. To identify loci potentially containing genetic variants associated with risk of psychosis in LOAD, a total of 263 families from the National Institute of Aging-LOAD cohort were classified into psychotic (LOAD+P, n = 215) and nonpsychotic (LOAD-P, n = 48) families based on the presence/absence of psychosis during the course of LOAD. The LOAD+P families yielded strong evidence of linkage on chromosome 19q13 (two-point [2-pt] ​logarithm of odds [LOD] = 3.8, rs2285513 and multipoint LOD = 2.7, rs541169). Joint linkage and association in 19q13 region detected strong association with rs2945988 (p = 8.7 × 10(-7)). Linkage results for the LOAD-P families yielded nonsignificant 19q13 LOD scores. Several 19q13 single-nucleotide polymorphisms generalized the association of LOAD+P in a Caribbean Hispanic (CH) cohort, and the strongest signal was rs10410711 (pmeta = 5.1 × 10(-5)). A variant located 24 kb upstream of rs10410711 and rs10421862 was strongly associated with LOAD+P (pmeta = 1.0 × 10(-5)) in a meta-analysis of the CH cohort and an additional non-Hispanic Caucasian dataset. Identified variants rs2945988 and rs10421862 affect brain gene expression levels. Our results suggest that genetic variants in genes on 19q13, some of which are involved in brain development and neurodegeneration, may influence the susceptibility to psychosis in LOAD patients.

Indexed as

Genetic Association StudiesAgedAged, 80 and overAlzheimer DiseaseChromosomes, Human, Pair 19Cohort StudiesDatasets as TopicFemaleGenetic Predisposition to DiseaseGenetic VariationHumansMaleMeta-Analysis as TopicMiddle AgedPolymorphism, Single NucleotidePsychotic DisordersAssociation analysisGenome-wide linkage analysisLate-onset Alzheimer’s diseaseNon-Hispanic Caucasian and Caribbean Hispanic ancestry populationsPsychosis

Identifiers

PMID26359528
PMCPMC4609604
OpenAlexW1945003804

What OpenQuestion holds

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Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.