ArticleScience (New York, N.Y.)2015
RETRACTED: The inner centromere-shugoshin network prevents chromosomal instability.
Article in Science (New York, N.Y.), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 46 citations in OpenAlex.
- Cohesin-mediated stabilization of the CCAN complex at kinetochores in mitosis.Current biology : CB · 2025Article
- SGOL2 is a novel prognostic marker and fosters disease progression via a MAD2-mediated pathway in hepatocellular carcinoma.Biomarker research · 2022Article
- Aneuploidy tolerance caused by BRG1 loss allows chromosome gains and recovery of fitness.Nature communications · 2022Article
- Reproducible image handling and analysis.The EMBO journal · 2021Article
- Large domains of heterochromatin direct the formation of short mitotic chromosome loops.eLife · 2020Article
- Article
- Multiple determinants and consequences of cohesion fatigue in mammalian cells.Molecular biology of the cell · 2018Article
- Ten principles of heterochromatin formation and function.Nature reviews. Molecular cell biology · 2018Review
- HP1 links centromeric heterochromatin to centromere cohesion in mammals.EMBO reports · 2018Article
- UBASH3B-mediated silencing of the mitotic checkpoint: Therapeutic perspectives in cancer.Molecular & cellular oncology · 2018Article
- Unresolved recombination intermediates lead to ultra-fine anaphase bridges, chromosome breaks and aberrations.Nature cell biology · 2018Article
- Rapid molecular assays to study human centromere genomics.Genome research · 2017Article
- Calcium depletion destabilises kinetochore fibres by the removal of CENP-F from the kinetochore.Scientific reports · 2017Article
- Potential biomarkers of DNA replication stress in cancer.Oncotarget · 2017Review
- Inner centromere localization of the CPC maintains centromere cohesion and allows mitotic checkpoint silencing.Nature communications · 2017Article
- Review
- The Role of Aneuploidy in Cancer Evolution.Cold Spring Harbor perspectives in medicine · 2017Review
- Microtubule dynamics decoded by the epigenetic state of centromeric chromatin.Current genetics · 2016Review
- A novel prognostic marker of non-small cell lung cancer: chromosome 9 open reading frame 86 (Journal of thoracic disease · 2016Article
- SGO1 is involved in the DNA damage response in MYCN-amplified neuroblastoma cells.Scientific reports · 2016Article
Corrections and comments
- Retraction · 2017-09-03Error in Image · Investigation by Company/Institution · Investigation by Third Party · Manipulation of Images · Misconduct - Official Investigation(s) and/or Finding(s) · Misconduct by Author · · Yoshino Watanbe has finding of misconduct. http://www.iam.u-tokyo.ac.jp/en/wp-content/uploads/sites/3/2017/09/report_20170906_e.pdfsee also https://sites.google.com/view/yoshinori-watanabe-corrections/%E3%83%9B%E3%83%BC%E3%83%A0
- Commented on by
- RetractedRetraction.2017
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chromosomal instability (CIN) is a major trait of cancer cells and a potent driver of tumor progression. However, the molecular mechanisms underlying CIN still remain elusive. We found that a number of CIN(+) cell lines have impairments in the integrity of the conserved inner centromere-shugoshin (ICS) network, which coordinates sister chromatid cohesion and kinetochore-microtubule attachment. These defects are caused mostly by the loss of histone H3 lysine 9 trimethylation at centromeres and sometimes by a reduction in chromatin-associated cohesin; both pathways separately sustain centromeric shugoshin stability. Artificial restoration of the ICS network suppresses chromosome segregation errors in a wide range of CIN(+) cells, including RB- and BRCA1-deficient cells. Thus, dysfunction of the ICS network might be a key mechanism underlying CIN in human tumorigenesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.