Evidence map›Paper›PMID 26359227›Full record

ArticlePsychopharmacology2015

Effects of cholinesterase inhibitor on brain activation in Alzheimer's patients measured with functional near-infrared spectroscopy.

Florian G Metzger, Ann-Christine Ehlis, Florian B Haeussinger, Andreas J Fallgatter, Katja Hagen

Abstract read
PubMed Publisher
In one paragraph

Article in Psychopharmacology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
0.8field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.

  1. Pooled it
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  3. Review
  4. Review
  5. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Florian G MetzgerPsychophysiology and Optical Imaging; Department of Psychiatry and Psychotherapy, University Hospital of Tuebingen, Calwerstrasse 14, 72076, Tuebingen, Germany. florian.metzger@med.uni-tuebingen.de.ORCID http://orcid.org/0000-0002-8236-1170
Ann-Christine EhlisPsychophysiology and Optical Imaging; Department of Psychiatry and Psychotherapy, University Hospital of Tuebingen, Calwerstrasse 14, 72076, Tuebingen, Germany.
Florian B HaeussingerPsychophysiology and Optical Imaging; Department of Psychiatry and Psychotherapy, University Hospital of Tuebingen, Calwerstrasse 14, 72076, Tuebingen, Germany.
Andreas J FallgatterPsychophysiology and Optical Imaging; Department of Psychiatry and Psychotherapy, University Hospital of Tuebingen, Calwerstrasse 14, 72076, Tuebingen, Germany.
Katja HagenPsychophysiology and Optical Imaging; Department of Psychiatry and Psychotherapy, University Hospital of Tuebingen, Calwerstrasse 14, 72076, Tuebingen, Germany.
Optica · USSTZ eyetrial · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

rationaleNeurobiological effects of neuropsychiatric medication can contribute to the understanding of mechanisms of action and to the evaluation of target medication effects. Cholinesterase inhibitors (ChEI) have been used in patients with Alzheimer's disease (AD) for years with only small knowledge about the underlying neurobiological effects. The measurement of brain activation links neurobiological and functional aspects but is challenging in the group of demented patients; here, an alternative method, functional near-infrared spectroscopy (fNIRS), is introduced to measure those medication effects.

objectivesThe current study investigated the influence of ChEI on cortical activation of patients with AD measured using fNIRS during a verbal fluency task (VFT).

methodsIn this study, 24 probable AD patients were investigated three times using fNIRS: before medication with rivastigmine was given (t0), when the medication was at the target dose after 4 weeks (t1), and after the target dose was kept constant for a further 8 weeks (t2).

resultsThe results show a concentration increase of oxygenated hemoglobin as measured with fNIRS from t0 to t2 in speech relevant areas and a general decrease in prefrontal areas. Behaviorally, an improvement was found for the VFT used to measure cortical activation during fNIRS. In the neuropsychological test battery, no significant changes were found, yet high effect sizes for the mini mental status examination, immediate and delayed word list recall were found.

conclusionsThe results indicate a positive effect of ChEI on cognitive function. The underlying cortical changes can be imaged using fNIRS.

Indexed as

AgedAged, 80 and overAlzheimer DiseaseBrainCholinesterase InhibitorsCognitionFemaleHumansMaleMiddle AgedNeuropsychological TestsPsychomotor PerformanceRivastigmineSpectroscopy, Near-InfraredSpeechTreatment OutcomeCholinesterase InhibitorsRivastigmineAlzheimer’s dementiaCholinesterase inhibitorsFunctional near-infrared spectroscopyMedication against dementiaRivastigmine patch

Identifiers

PMID26359227
OpenAlexW2201600572

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.