ArticleMetabolic brain disease2015
Inflammatory and metabolic markers and short-time outcome in patients with acute ischemic stroke in relation to TOAST subtypes.
Article in Metabolic brain disease, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.
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Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 33 citations in OpenAlex.
- Effect of exercise-based interventions on stroke rehabilitation: an umbrella review of systematic reviews and meta-analyses.Journal of neuroengineering and rehabilitation · 2025Pooled it
- Blood-based protein biomarkers during the acute ischemic stroke treatment window: a systematic review.Frontiers in neurology · 2024Pooled it
- LINC01094 exacerbates acute cerebral infarction by regulating miR-499a-5p.Metabolic brain disease · 2026Article
- Effect of TyG index on endovascular therapy in large vessel occlusion stroke with different etiologies.BMC neurology · 2026Article
- Relationship between high-sensitivity C-reactive protein/lymphocyte ratio and post-thrombolysis short-term outcome in acute ischemic stroke patients.Frontiers in aging neuroscience · 2026Article
- Characteristics of peripheral immune response induced by large-vessel occlusion in patients with acute ischemic stroke.Frontiers in neurology · 2024Article
- Abnormal expression of miRNA-122 in cerebral infarction and related mechanism of regulating vascular endothelial cell proliferation and apoptosis by targeting CCNG1.Clinics (Sao Paulo, Brazil) · 2023Article
- Predicting futile recanalization, malignant cerebral edema, and cerebral herniation using intelligible ensemble machine learning following mechanical thrombectomy for acute ischemic stroke.Frontiers in neurology · 2022Article
- Carotid intima media thickness measurements coupled with stroke severity strongly predict short-term outcome in patients with acute ischemic stroke: a machine learning study.Metabolic brain disease · 2021Article
- Hyperhomocysteinemia and Ischemic Stroke: A Potential Dose-Response Association-A Systematic Review and Meta-analysis.TH open : companion journal to thrombosis and haemostasis · 2021Review
- Search for Reliable Circulating Biomarkers to Predict Carotid Plaque Vulnerability.International journal of molecular sciences · 2020Review
- The Diagnostic Value of sTWEAK in Acute Ischemic StrokeBalkan medical journal · 2020Article
- Blood-Based Biomarkers Are Associated with Different Ischemic Stroke Mechanisms and Enable Rapid Classification between Cardioembolic and Atherosclerosis Etiologies.Diagnostics (Basel, Switzerland) · 2020Review
- Monocyte-to-High-Density Lipoprotein Ratio Predicts the Outcome of Acute Ischemic Stroke.Journal of atherosclerosis and thrombosis · 2020Article
- The Role of Selected Pro-Inflammatory Cytokines in Pathogenesis of Ischemic Stroke.Clinical interventions in aging · 2020Review
- Low free triiodothyronineis predicts worsen neurological outcome of patients with acute ischemic stroke: a retrospective study with bioinformatics analysis.BMC neurology · 2019Article
- Severe Blood-Brain Barrier Disruption in Cardioembolic Stroke.Frontiers in neurology · 2018Article
- The influence of dehydration on the prognosis of acute ischemic stroke for patients treated with tissue plasminogen activator.BMC cardiovascular disorders · 2017Article
- Influence of renal function on the association between homocysteine level and risk of ischemic stroke.American journal of translational research · 2017Article
- Update on Inflammatory Biomarkers and Treatments in Ischemic Stroke.International journal of molecular sciences · 2016Review
Corrections and comments
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Authors and funding
17 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of this study was to evaluate the association between inflammatory and metabolic markers and short-time outcome with acute ischemic stroke subtypes. A total of 121 patients was classified according to TOAST criteria, such as large artery atherosclerosis (LAAS), lacunar infarct (LAC), cardioembolic infarct (CEI), other determined etiology (ODE), and undetermined etiology (UDE). The functional impairment was evaluated within the first eight hours of stroke and the outcome after three-month follow-up using the modified Rankin Scale. Blood samples were obtained up to 24 h of stroke. Compared with 96 controls, patients with LAAS, CEI, and LAC subtypes showed higher levels of white blood cells, high-sensitivity C-reactive protein (hsCRP), interleukin 6 (IL-6), metalloproteinase 9 (MMP-9), glucose, and iron (p < 0.05); and lower high-density lipoprotein cholesterol (HDL-C) (p < 0.0001); platelets, insulin, insulin resistance, and homocysteine were higher in LAC (p < 0.0001); ferritin was higher in LAAS (p < 0.0001); and total cholesterol (TC) was lower in LAAS and CEI (p < 0.01). When stroke subtypes were compared, insulin was higher in LAAS vs. LAC and in LAC vs. CEI (p < 0.05); and TC was lower in LAAS vs. LAC (p < 0.05). Outcome and rate of mortality after three-month were higher in LAAS vs. LAC (p < 0.001 and p = 0.0391 respectively). The results underscored the important role of the inflammatory response and metabolic changes in the pathogenesis of ischemic stroke subtypes that might be considered on the initial evaluation of stroke patients to identify those that could benefit with individualized therapeutic strategies that taken into account these markers after acute ischemic event.
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