Evidence map›Paper›PMID 26358529›Full record

ArticleScientific reports2015

Depth-resolved rhodopsin molecular contrast imaging for functional assessment of photoreceptors.

Tan Liu, Rong Wen, Byron L Lam, Carmen A Puliafito, Shuliang Jiao

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.6field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 12 citations in OpenAlex.

  1. Trial
  2. Article
  3. Review
  4. Article
  5. Review
  6. Review
  7. Emerging imaging developments in experimental vision sciences and ophthalmology.Experimental biology and medicine (Maywood, N.J.) · 2021
    Article
  8. Article
  9. Article
  10. Visible-light optical coherence tomography: a review.Journal of biomedical optics · 2017
    Review
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Tan LiuDepartment of Biomedical Engineering, Florida International University, Miami, Florida 33174, USA.
Rong WenBascom Palmer Eye Institute, Miller School of Medicine, University of Miami, Miami, Florida 33136, USA.
Byron L LamBascom Palmer Eye Institute, Miller School of Medicine, University of Miami, Miami, Florida 33136, USA.
Carmen A PuliafitoKeck School of Medicine, University of Southern California, Los Angeles, California 90089, USA.
Shuliang JiaoDepartment of Biomedical Engineering, Florida International University, Miami, Florida 33174, USA.
Florida International University · USUniversity of Miami · USUniversity of Southern California · US

Funding

Shared Equipment ModuleP30EY014801 · NEI · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI Victor L Perez · 2004 to 2026
$12.2M
Multimodal Retinal Functional Imaging for Diabetic RetinopathyR01EY019951 · NEI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI FAWZI, AMANI A, JIAO, SHULIANG · 2011 to 2015
$3.0M
DHDDS and Retinal DegenerationR01EY023666 · NEI · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI WEN, RONG · 2014 to 2018
$2.8M
NEI NIH HHS P30 EY014801NEI NIH HHS P30EY014801NEI NIH HHS R01 EY019951NEI NIH HHS R01EY019951NEI NIH HHS R01 EY023666NEI NIH HHS R01EY023666
6 · The paper itself

Abstract

Rhodopsin, the light-sensing molecule in the outer segments of rod photoreceptors, is responsible for converting light into neuronal signals in a process known as phototransduction. Rhodopsin is thus a functional biomarker for rod photoreceptors. Here we report a novel technology based on visible-light optical coherence tomography (VIS-OCT) for in vivo molecular imaging of rhodopsin. The depth resolution of OCT allows the visualization of the location where the change of optical absorption occurs and provides a potentially accurate assessment of rhodopsin content by segmentation of the image at the location. Rhodopsin OCT can be used to quantitatively image rhodopsin distribution and thus assess the distribution of functional rod photoreceptors in the retina. Rhodopsin OCT can bring significant impact into ophthalmic clinics by providing a tool for the diagnosis and severity assessment of a variety of retinal conditions.

Indexed as

Molecular ImagingAnimalsHumansImaging, Three-DimensionalLightPhotoreceptor CellsRatsReproducibility of ResultsRhodopsinTomography, Optical CoherenceRhodopsin

Identifiers

PMID26358529
PMCPMC4566094
OpenAlexW2438774257

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.