ArticlePlant physiology2015
A Kelch Domain-Containing F-Box Coding Gene Negatively Regulates Flavonoid Accumulation in Muskmelon.
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Article in Plant physiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers.
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62citing papers in PubMed
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Who cites it
62 citing papers in PubMed.
- Introgression line libraries in melon (Molecular breeding : new strategies in plant improvement · 2026Review
- Ancient DNA reveals early use of melons in China's Song dynasty.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Polyploidy-driven expansion and regulatory diversification of the Kelch repeat F-box gene family in sweetpotato.BMC genomics · 2026Article
- Post-transcriptional and post-translational regulation of anthocyanin biosynthesis in sweetpotato by Ib-miR2111 and IbKFB: Implications for health promotion.Journal of advanced research · 2025Article
- A transposon insertion inHorticulture research · 2025Article
- A chromosome-levelActa pharmaceutica Sinica. B · 2025Article
- Mapping and functional characterization of the golden fruit 1 (gf1) in melon (Cucumis melo L.).TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2025Article
- The Role of E3 Ubiquitin Ligase GeneInternational journal of molecular sciences · 2025Review
- Uncovering the genetic mechanism of rind color trait in watermelon using fine mapping and comparative transcriptomic analysis.Frontiers in plant science · 2025Article
- Identification and analysis of drought-responsive F-box genes in upland rice and involvement of OsFBX148 in ABA response and ROS accumulation.BMC plant biology · 2024Article
- Mapping and transcriptomic profiling reveal that the KNAT6 gene is involved in the dark green peel colour of mature pumpkin fruit (Cucurbita maxima L.).TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2024Article
- Identification of tomato F-box proteins functioning in phenylpropanoid metabolism.Plant molecular biology · 2024Article
- Genetic tapestry of Capsicum fruit colors: a comparative analysis of four cultivated species.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2024Article
- Genetic regulation of volatile production in two melon introgression line collections with contrasting ripening behavior.Horticulture research · 2024Article
- Identification of a recessive geneFrontiers in plant science · 2024Article
- Genetic analysis and preliminary mapping by BSA-seq of the CmSR gene regulating the spotted rind trait in melon (Cucumis melo L.).Genetics and molecular biology · 2024Article
- A Novel Introgression Line Library Derived from a Wild Melon Gives Insights into the Genetics of Melon Domestication, Uncovering New Genetic Variability Useful for Breeding.International journal of molecular sciences · 2023Article
- Forward genetic studies revealFrontiers in plant science · 2023Article
- Fine mapping and identifying candidate gene ofFrontiers in plant science · 2023Article
- Genome-Wide Analysis and Characterization of Eggplant F-Box Gene Superfamily: Gene Evolution and Expression Analysis under Stress.International journal of molecular sciences · 2022Article
2 more citing papers are in PubMed but not listed here.
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Authors and funding
13 authors.
Ari FederCucurbit Section, Newe Ya'ar Research Center, Agricultural Research Organization (ARO), Ramat Yishay 3009500, Israel (A.F., J.B., E.L., N.K., A.M., R.D.-R., V.P., Y.T.);Faculty of Biotechnology and Food Engineering, Technion, Israel Institute of Technology, Haifa 32000, Israel (A.F., Y.K.);Boyce Thompson Institute for Plant Research, Cornell University, Ithaca, New York 14853 (S.G., Z.F.); andPlant Science (A.A.S.) andPlant Protection (A.G.) Institutes, ARO, The Volcani Center, Bet Dagan 50250, Israel.
Joseph BurgerCucurbit Section, Newe Ya'ar Research Center, Agricultural Research Organization (ARO), Ramat Yishay 3009500, Israel (A.F., J.B., E.L., N.K., A.M., R.D.-R., V.P., Y.T.);Faculty of Biotechnology and Food Engineering, Technion, Israel Institute of Technology, Haifa 32000, Israel (A.F., Y.K.);Boyce Thompson Institute for Plant Research, Cornell University, Ithaca, New York 14853 (S.G., Z.F.); andPlant Science (A.A.S.) andPlant Protection (A.G.) Institutes, ARO, The Volcani Center, Bet Dagan 50250, Israel.
Shan GaoCucurbit Section, Newe Ya'ar Research Center, Agricultural Research Organization (ARO), Ramat Yishay 3009500, Israel (A.F., J.B., E.L., N.K., A.M., R.D.-R., V.P., Y.T.);Faculty of Biotechnology and Food Engineering, Technion, Israel Institute of Technology, Haifa 32000, Israel (A.F., Y.K.);Boyce Thompson Institute for Plant Research, Cornell University, Ithaca, New York 14853 (S.G., Z.F.); andPlant Science (A.A.S.) andPlant Protection (A.G.) Institutes, ARO, The Volcani Center, Bet Dagan 50250, Israel.ORCID http://orcid.org/0000-0002-8919-1338
Efraim LewinsohnCucurbit Section, Newe Ya'ar Research Center, Agricultural Research Organization (ARO), Ramat Yishay 3009500, Israel (A.F., J.B., E.L., N.K., A.M., R.D.-R., V.P., Y.T.);Faculty of Biotechnology and Food Engineering, Technion, Israel Institute of Technology, Haifa 32000, Israel (A.F., Y.K.);Boyce Thompson Institute for Plant Research, Cornell University, Ithaca, New York 14853 (S.G., Z.F.); andPlant Science (A.A.S.) andPlant Protection (A.G.) Institutes, ARO, The Volcani Center, Bet Dagan 50250, Israel.
Nurit KatzirCucurbit Section, Newe Ya'ar Research Center, Agricultural Research Organization (ARO), Ramat Yishay 3009500, Israel (A.F., J.B., E.L., N.K., A.M., R.D.-R., V.P., Y.T.);Faculty of Biotechnology and Food Engineering, Technion, Israel Institute of Technology, Haifa 32000, Israel (A.F., Y.K.);Boyce Thompson Institute for Plant Research, Cornell University, Ithaca, New York 14853 (S.G., Z.F.); andPlant Science (A.A.S.) andPlant Protection (A.G.) Institutes, ARO, The Volcani Center, Bet Dagan 50250, Israel.ORCID http://orcid.org/0000-0001-8858-8395
Arthur A SchafferCucurbit Section, Newe Ya'ar Research Center, Agricultural Research Organization (ARO), Ramat Yishay 3009500, Israel (A.F., J.B., E.L., N.K., A.M., R.D.-R., V.P., Y.T.);Faculty of Biotechnology and Food Engineering, Technion, Israel Institute of Technology, Haifa 32000, Israel (A.F., Y.K.);Boyce Thompson Institute for Plant Research, Cornell University, Ithaca, New York 14853 (S.G., Z.F.); andPlant Science (A.A.S.) andPlant Protection (A.G.) Institutes, ARO, The Volcani Center, Bet Dagan 50250, Israel.
Ayala MeirCucurbit Section, Newe Ya'ar Research Center, Agricultural Research Organization (ARO), Ramat Yishay 3009500, Israel (A.F., J.B., E.L., N.K., A.M., R.D.-R., V.P., Y.T.);Faculty of Biotechnology and Food Engineering, Technion, Israel Institute of Technology, Haifa 32000, Israel (A.F., Y.K.);Boyce Thompson Institute for Plant Research, Cornell University, Ithaca, New York 14853 (S.G., Z.F.); andPlant Science (A.A.S.) andPlant Protection (A.G.) Institutes, ARO, The Volcani Center, Bet Dagan 50250, Israel.
Rachel Davidovich-RikanatiCucurbit Section, Newe Ya'ar Research Center, Agricultural Research Organization (ARO), Ramat Yishay 3009500, Israel (A.F., J.B., E.L., N.K., A.M., R.D.-R., V.P., Y.T.);Faculty of Biotechnology and Food Engineering, Technion, Israel Institute of Technology, Haifa 32000, Israel (A.F., Y.K.);Boyce Thompson Institute for Plant Research, Cornell University, Ithaca, New York 14853 (S.G., Z.F.); andPlant Science (A.A.S.) andPlant Protection (A.G.) Institutes, ARO, The Volcani Center, Bet Dagan 50250, Israel.
Vitaly PortnoyCucurbit Section, Newe Ya'ar Research Center, Agricultural Research Organization (ARO), Ramat Yishay 3009500, Israel (A.F., J.B., E.L., N.K., A.M., R.D.-R., V.P., Y.T.);Faculty of Biotechnology and Food Engineering, Technion, Israel Institute of Technology, Haifa 32000, Israel (A.F., Y.K.);Boyce Thompson Institute for Plant Research, Cornell University, Ithaca, New York 14853 (S.G., Z.F.); andPlant Science (A.A.S.) andPlant Protection (A.G.) Institutes, ARO, The Volcani Center, Bet Dagan 50250, Israel.ORCID http://orcid.org/0000-0003-1130-6788
Amit Gal-OnCucurbit Section, Newe Ya'ar Research Center, Agricultural Research Organization (ARO), Ramat Yishay 3009500, Israel (A.F., J.B., E.L., N.K., A.M., R.D.-R., V.P., Y.T.);Faculty of Biotechnology and Food Engineering, Technion, Israel Institute of Technology, Haifa 32000, Israel (A.F., Y.K.);Boyce Thompson Institute for Plant Research, Cornell University, Ithaca, New York 14853 (S.G., Z.F.); andPlant Science (A.A.S.) andPlant Protection (A.G.) Institutes, ARO, The Volcani Center, Bet Dagan 50250, Israel.ORCID http://orcid.org/0000-0002-1361-1877
Zhangjun FeiCucurbit Section, Newe Ya'ar Research Center, Agricultural Research Organization (ARO), Ramat Yishay 3009500, Israel (A.F., J.B., E.L., N.K., A.M., R.D.-R., V.P., Y.T.);Faculty of Biotechnology and Food Engineering, Technion, Israel Institute of Technology, Haifa 32000, Israel (A.F., Y.K.);Boyce Thompson Institute for Plant Research, Cornell University, Ithaca, New York 14853 (S.G., Z.F.); andPlant Science (A.A.S.) andPlant Protection (A.G.) Institutes, ARO, The Volcani Center, Bet Dagan 50250, Israel.ORCID http://orcid.org/0000-0001-9684-1450
Yechezkel KashiCucurbit Section, Newe Ya'ar Research Center, Agricultural Research Organization (ARO), Ramat Yishay 3009500, Israel (A.F., J.B., E.L., N.K., A.M., R.D.-R., V.P., Y.T.);Faculty of Biotechnology and Food Engineering, Technion, Israel Institute of Technology, Haifa 32000, Israel (A.F., Y.K.);Boyce Thompson Institute for Plant Research, Cornell University, Ithaca, New York 14853 (S.G., Z.F.); andPlant Science (A.A.S.) andPlant Protection (A.G.) Institutes, ARO, The Volcani Center, Bet Dagan 50250, Israel.
Yaakov TadmorCucurbit Section, Newe Ya'ar Research Center, Agricultural Research Organization (ARO), Ramat Yishay 3009500, Israel (A.F., J.B., E.L., N.K., A.M., R.D.-R., V.P., Y.T.);Faculty of Biotechnology and Food Engineering, Technion, Israel Institute of Technology, Haifa 32000, Israel (A.F., Y.K.);Boyce Thompson Institute for Plant Research, Cornell University, Ithaca, New York 14853 (S.G., Z.F.); andPlant Science (A.A.S.) andPlant Protection (A.G.) Institutes, ARO, The Volcani Center, Bet Dagan 50250, Israel tadmory@agri.gov.il.ORCID http://orcid.org/0000-0003-3311-2503
Funding
No grant is acknowledged in the PubMed record.
Abstract
The flavonoids are phenylpropanoid-derived metabolites that are ubiquitous in plants, playing many roles in growth and development. Recently, we observed that fruit rinds of yellow casaba muskmelons (Cucumis melo 'Inodorous Group') accumulate naringenin chalcone, a yellow flavonoid pigment. With RNA-sequencing analysis of bulked segregants representing the tails of a population segregating for naringenin chalcone accumulation followed by fine mapping and genetic transformation, we identified a Kelch domain-containing F-box protein coding (CmKFB) gene that, when expressed, negatively regulates naringenin chalcone accumulation. Additional metabolite analysis indicated that downstream flavonoids are accumulated together with naringenin chalcone, whereas CmKFB expression diverts the biochemical flux toward coumarins and general phenylpropanoids. These results show that CmKFB functions as a posttranscriptional regulator that diverts flavonoid metabolic flux.
Indexed as
Gene Expression Regulation, PlantBase SequenceChalconesCucumis meloF-Box ProteinsFlavonoidsFruitGene ExpressionGenetic LociMetabolic Flux AnalysisMolecular Sequence DataPhenotypePhylogenyPlant LeavesPlant ProteinsPolymorphism, Single Nucleotide1-phenylpropanolChalconesF-Box ProteinsFlavonoidsnaringenin chalconePlant ProteinsPropanols
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