ArticleDNA research : an international journal for rapid publication of reports on genes and genomes2015
Genome-wide analysis of DNA methylation in pigs using reduced representation bisulfite sequencing.
Article in DNA research : an international journal for rapid publication of reports on genes and genomes, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed, 58 citations in OpenAlex.
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- Compound Danshen Dripping Pill inhibits hypercholesterolemia/atherosclerosis-induced heart failure in ApoE and LDLR dual deficient miceActa pharmaceutica Sinica. B · 2023Article
- Comparing the Biological Properties of Double-Stranded DNA Extracted from Human and Porcine Placenta and Salmon Sperm.Reports of biochemistry & molecular biology · 2023Article
- Genome-wide DNA methylation differences between conservation and breeding populations of Shaoxing ducks.Heliyon · 2022Article
- Development of an Immortalized Porcine Fibroblast Cell Panel With Different Swine Leukocyte Antigen Genotypes.Frontiers in genetics · 2022Article
- Exposure of pigs to glyphosate affects gene-specific DNA methylation and gene expression.Toxicology reports · 2022Article
- Generating Sequencing-Based DNA Methylation Maps from Low DNA Input Samples.Methods in molecular biology (Clifton, N.J.) · 2022Article
- Epigenetic clock and DNA methylation analysis of porcine models of aging and obesity.GeroScience · 2021Article
- Genome-wide DNA methylation analysis in Chinese Chenghua and Yorkshire pigs.BMC genomic data · 2021Article
- DNA methylation landscape of 16 canine somatic tissues by methylation-sensitive restriction enzyme-based next generation sequencing.Scientific reports · 2021Article
- Genome-Wide DNA Methylome and Transcriptome Analysis of Porcine Testicular Cells Infected With Transmissible Gastroenteritis Virus.Frontiers in veterinary science · 2021Article
- Comparative whole genome DNA methylation profiling across cattle tissues reveals global and tissue-specific methylation patterns.BMC biology · 2020Article
- Characterization of Global DNA Methylation in Different Gene Regions Reveals Candidate Biomarkers in Pigs with High and Low Levels of Boar Taint.Veterinary sciences · 2020Article
- Article
- Putative Epigenetic Biomarkers of Stress in Red Blood Cells of Chickens Reared Across Different Biomes.Frontiers in genetics · 2020Article
- Analysis of allele-specific expression using RNA-seq of the Korean native pig and Landrace reciprocal cross.Asian-Australasian journal of animal sciences · 2019Article
- DNA methylation patterns vary in boar sperm cells with different levels of DNA fragmentation.BMC genomics · 2019Article
- A Nutrigenomics Approach Using RNA Sequencing Technology to Study Nutrient-Gene Interactions in Agricultural Animals.Current developments in nutrition · 2019Review
- DNA methylation analysis of porcine mammary epithelial cells reveals differentially methylated loci associated with immune response against Escherichia coli challenge.BMC genomics · 2019Article
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
DNA methylation plays a major role in the epigenetic regulation of gene expression. Although a few DNA methylation profiling studies of porcine genome which is one of the important biomedical models for human diseases have been reported, the available data are still limited. We tried to study methylation patterns of diverse pig tissues as a study of the International Swine Methylome Consortium to generate the swine reference methylome map to extensively evaluate the methylation profile of the pig genome at a single base resolution. We generated and analysed the DNA methylome profiles of five different tissues and a cell line originated from pig. On average, 39.85 and 62.1% of cytosine and guanine dinucleotides (CpGs) of CpG islands and 2 kb upstream of transcription start sites were covered, respectively. We detected a low rate (an average of 1.67%) of non-CpG methylation in the six samples except for the neocortex (2.3%). The observed global CpG methylation patterns of pigs indicated high similarity to other mammals including humans. The percentage of CpG methylation associated with gene features was similar among the tissues but not for a 3D4/2 cell line. Our results provide essential information for future studies of the porcine epigenome.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.