ArticleJournal of experimental botany2015
Acetyl-CoA synthetase is activated as part of the PDH-bypass in the oleaginous green alga Chlorella desiccata.
Article in Journal of experimental botany, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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14 citing papers in PubMed, 37 citations in OpenAlex.
- Nutritional Quality of Basal Resource in Stream Food Webs Increased with Light Reduction-Implications for Riparian Revegetation.Microbial ecology · 2024Article
- Strategies of NaCl Tolerance in Saline-Alkali-Tolerant Green MicroalgaPlants (Basel, Switzerland) · 2023Article
- Simultaneous DHA and organic selenium production by Schizochytrium sp.: a theoretical basis.Scientific reports · 2023Article
- Fatty Acid Production and Direct Acyl Transfer through Polar Lipids Control TAG Biosynthesis during Nitrogen Deprivation in the Halotolerant AlgaMarine drugs · 2021Article
- The oleaginous astaxanthin-producing alga Chromochloris zofingiensis: potential from production to an emerging model for studying lipid metabolism and carotenogenesis.Biotechnology for biofuels · 2021Review
- Lipid Droplets Mediate Salt Stress Tolerance inPlant physiology · 2019Article
- Subcellular Energetics and Carbon Storage inCells · 2019Review
- Triacylglycerol is produced from starch and polar lipids in the green alga Dunaliella tertiolecta.Journal of experimental botany · 2017Article
- Dynamic metabolic profiling together with transcription analysis reveals salinity-induced starch-to-lipid biosynthesis in alga Chlamydomonas sp. JSC4.Scientific reports · 2017Article
- Loss of Cardiolipin Leads to Perturbation of Acetyl-CoA Synthesis.The Journal of biological chemistry · 2017Article
- Time-resolved transcriptome analysis and lipid pathway reconstruction of the oleaginous green microalgaBiotechnology for biofuels · 2017Article
- Nitrogen-induced metabolic changes and molecular determinants of carbon allocation in Dunaliella tertiolecta.Scientific reports · 2016Article
- Hypoxia response in Arabidopsis roots infected by Plasmodiophora brassicae supports the development of clubroot.BMC plant biology · 2016Article
- The dilemma for lipid productivity in green microalgae: importance of substrate provision in improving oil yield without sacrificing growth.Biotechnology for biofuels · 2016Review
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2 authors at 1 institution in 1 country.
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Abstract
In a recent study, it has been shown that biosynthesis of triacylglycerol (TAG) in the oleaginous green alga Chlorella desiccata is preceded by a large increase in acetyl-coenzyme A (Ac-CoA) levels and by upregulation of plastidic pyruvate dehydrogenase (ptPDH). It was proposed that the capacity to accumulate high TAG critically depends on enhanced production of Ac-CoA. In this study, two alternative Ac-CoA producers-plastidic Ac-CoA synthase (ptACS) and ATP citrate lyase (ACL)-are shown to be upregulated prior to TAG accumulation under nitrogen deprivation in the oleaginous species C. desiccata, but not in the moderate TAG accumulators Dunaliella tertiolecta and Chlamydomonas reinhardtii. Measurements of endogenous acetate production and of radiolabelled acetate incorporation into lipids are consistent with the upregulation of ptACS, but suggest that its contribution to the overall TAG biosynthesis is negligible. Induction of ACS and production of endogenous acetate are correlated with activation of alcohol dehydrogenase, suggesting that the upregulation of ptACS is associated with activation of PDH-bypass in C. desiccata. It is proposed that activation of the PDH-bypass in C. desiccata is needed to enable a high rate of lipid biosynthesis under nitrogen deprivation by controlling the level of pyruvate reaching ptPHD and/or mtPDH. This may be an important parameter for massive TAG accumulation in microalgae.
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