Evidence map›Paper›PMID 26357672›Full record

ArticleEndoscopy international open2015

Evaluation of anesthesia management, feasibility and efficacy of peroral endoscopic myotomy (POEM) for achalasia performed in the endoscopy unit.

Dennis Yang, Davinderbir Pannu, Qing Zhang, Jeffrey D White, Peter V Draganov

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in Endoscopy international open, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06918730 (Prospective Randomized Controlled Trial), which is not on this map. Cited by 27 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 1 pooled it
6.8field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06918730 nacompletednot on this mapstarted 2025, after this paper: background citation

Prospective Randomized Controlled Trial (RCT)Comparing Clinical Outcomes Between Underwater Versus Carbon Dioxide Insufflation During Peroral Endoscopic Myotomy (U-POEM Trial)

TypeinterventionalSponsorAdventHealthRan2025 to 2026Enrolled34ConditionsEsophageal Motility DisordersArmsU-POEM, CO2-POEM
3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 1 synthesis or guideline pooled it, 64 citations in OpenAlex.

  1. Standard length of peroral endoscopic myotomy (POEM) for achalasia: a systematic review and meta-analysis.Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus · 2024
    Pooled it
  2. Article
  3. Tension pneumoperitoneum combined with COFrontiers in medicine · 2026
    Article
  4. Saudi Gastroenterology Association (SGA) clinical care pathway and standards of care for peroral endoscopic myotomy (POEM) in achalasia.Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association · 2026
    Article
  5. Review
  6. Article
  7. The Ventilatory Changes of Pediatric Peroral Endoscopic Myotomy Patients.Turkish journal of anaesthesiology and reanimation · 2024
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Esophageal POEM: the new standard of care.Translational gastroenterology and hepatology · 2020
    Review
  13. Review
  14. Review
  15. Article
  16. Article
  17. POEM in the Treatment of Esophageal Disorders.Current treatment options in gastroenterology · 2018
    Review
  18. Review
  19. Article
  20. Anesthesia in per-oral endoscopic myotomy: A large tertiary care centre experience.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2017
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Dennis YangDivision of Gastroenterology, Hepatology and Nutrition, University of Florida, Gainesville, Florida, United States.
Davinderbir PannuDivision of Gastroenterology, Hepatology and Nutrition, University of Florida, Gainesville, Florida, United States.
Qing ZhangDivision of Gastroenterology, Hepatology and Nutrition, University of Florida, Gainesville, Florida, United States.
Jeffrey D WhiteDepartment of Anesthesia, University of Florida, Gainesville, Florida, United States.
Peter V DraganovDivision of Gastroenterology, Hepatology and Nutrition, University of Florida, Gainesville, Florida, United States.
University of Florida · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionData on anesthesia management and outcomes associated with peroral endoscopic myotomy (POEM) performed exclusively in the endoscopy unit are limited. In this prospective study, we evaluated the safety of anesthesia management, and the feasibility and efficacy of POEM performed exclusively in the endoscopy unit.

methodsA single-center prospective study of consecutive patients with achalasia treated with POEM in an endoscopy unit was performed. Safety of anesthesia management and POEM were determined by procedure-related adverse events. Feasibility was assessed by completion rate. Short-term efficacy was established by clinical success (Eckardt score ≤ 3) and by comparing Eckardt and dysphagia scores before and after POEM.

resultsPatients (n = 52) underwent POEM under general anesthesia with endotracheal intubation and positive pressure ventilation. Aspiration was prevented by keeping patients on a clear liquid diet before the procedure without requiring a prior esophagogastroduodenoscopy for esophageal content clearance. POEM completion rate was 96 % (50/52 patients). There was no post-POEM bleeding. Postprocedure leak was observed in one patient (3 %). Four patients (7.7 %) experienced mucosal injury, three of them were treated uneventfully endoscopically and one required laparoscopic repair. Clinical success was achieved in 88 % of patients. There was a significant decrease in the mean Eckardt score (8.1 to 1.4) and dysphagia score (2.4 to 0.4) (P < 0.0001) at the one month follow up after POEM.

conclusionAnesthesia management of POEM is safe in the endoscopy unit and aspiration can be prevented without requiring prior esophagogastroduodenoscopy for esophageal content clearance. Overall, POEM performed by a gastroenterologist in the endoscopy unit was feasible and effective for the treatment of achalasia.

Identifiers

PMID26357672
PMCPMC4554518
OpenAlexW2255343686

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.