ArticleBioMed research international2015
Effect of the Common Fat Mass and Obesity Associated Gene Variants on Obesity in Pakistani Population: A Case-Control Study.
Article in BioMed research international, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 3 of them syntheses that pooled it.
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Who cites it
14 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Impact of fat mass and obesity-associated (FTO) gene variants on adult obesity and overweight: a comprehensive meta-analysis.BMC endocrine disorders · 2026Pooled it
- Comparison of the risk of obesity in the FTO rs9939609 genotype in a multiethnic group in Asia systematic review and meta-analysis.Frontiers in medicine · 2025Pooled it
- Single nucleotide polymorphisms (SNPs) that are associated with obesity and type 2 diabetes among Asians: a systematic review and meta-analysis.Scientific reports · 2024Pooled it
- Genetic Risk of MASLD in Mongolians: Role ofCurrent issues in molecular biology · 2025Article
- Genetic association ofJournal of cardiovascular and thoracic research · 2024Article
- The association between FTO rs9939609 polymorphism and serum lipid profile in adult women.Diabetology & metabolic syndrome · 2021Article
- FTO gene polymorphism and longitudinal changes in nutritional/obesity status in children and adolescents: Schoolchildren's health cohort study.European journal of pediatrics · 2021Article
- Association and interaction of the FTO rs1421085 with overweight/obesity in a sample of Pakistani individuals.Eating and weight disorders : EWD · 2020Article
- Genetic variants in the fat mass and obesity-associated (FTO) gene confer risk for extreme obesity and modulate adiposity in a Brazilian population.Genetics and molecular biology · 2020Article
- The FTO genetic variants are associated with dietary intake and body mass index amongst Emirati population.PloS one · 2019Article
- The association of the fat mass and obesity-associated gene (FTO) rs9939609 polymorphism and the severe obesity in a Brazilian population.Diabetes, metabolic syndrome and obesity : targets and therapy · 2019Article
- Identification of genetic basis of obesity and mechanistic link of genes and lipids in Pakistani population.Bioscience reports · 2018Article
- Use of a gene score of multiple low-modest effect size variants can predict the risk of obesity better than the individual SNPs.Lipids in health and disease · 2018Observational
- Copy Number Variations in Candidate Genes and Intergenic Regions Affect Body Mass Index and Abdominal Obesity in Mexican Children.BioMed research international · 2017Article
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND/
objectiveObesity has become a global epidemic due to an increase in the number of obese individuals worldwide. There is little research in the field of obesity genetics in Pakistan. The aim of the current study was to analyze the association of common variants in Fat Mass and Obesity associated (FTO) gene with obesity in Pakistan, to find out the effect of the selected SNPs on anthropometric and biochemical traits, and to observe whether these variants act synergistically.
methodsSamples from 631 subjects were taken after informed consent and were used for serum parameters and genetic analysis. Lipid profile was determined, tetra-ARMS PCR was used for genotyping, and allele/genotype frequencies and genescore were calculated.
resultsAll FTO variants were associated with obesity, and some biochemical and anthropometric measures and had higher minor allele frequencies than those reported for Asian populations previously. The risk allele of each single nucleotide polymorphism resulted in an increase in BMI in a quantitative manner.
conclusionCommon forms of obesity are due to a combined net effect of many variants presented in same or different genes. The more the number of risk alleles present, the higher the risk and severity of obesity resulting from an increase in BMI.
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