ReviewMolecular biology international2015
Systems Medicine: The Application of Systems Biology Approaches for Modern Medical Research and Drug Development.
Review in Molecular biology international, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed.
- Basic and Clinical Scientists Working Together-Do We Make the Best of Both Worlds?Calcified tissue international · 2025Article
- Roadmap for a Systems Biology Initiative in Iran.Journal of medical signals and sensors · 2025Article
- Interdisciplinary Research in Iran VII: The Convergence of Biology and Artificial Intelligence.Journal of medical signals and sensors · 2025Article
- Redefining Roles: A Paradigm Shift in Tryptophan-Kynurenine Metabolism for Innovative Clinical Applications.International journal of molecular sciences · 2024Review
- Gene Dosage ofGenes · 2024Article
- DeeP4med: deep learning for P4 medicine to predict normal and cancer transcriptome in multiple human tissues.BMC bioinformatics · 2023Article
- Perspectives of (/memorandum for) systems thinking on COVID-19 pandemic and pathology.Journal of evaluation in clinical practice · 2023Article
- PROTEOMAS: a workflow enabling harmonized proteomic meta-analysis and proteomic signature mapping.Journal of cheminformatics · 2023Article
- Lactation physiokinetics-using advances in technology for a fresh perspective on human milk transfer.Frontiers in pediatrics · 2023Article
- Exosome Carrier Effects; Resistance to Digestion in Phagolysosomes May Assist Transfers to Targeted Cells; II Transfers of miRNAs Are Better Analyzed via Systems Approach as They Do Not Fit Conventional Reductionist Stoichiometric Concepts.International journal of molecular sciences · 2022Review
- The Quest for System-Theoretical Medicine in the COVID-19 Era.Frontiers in medicine · 2021Article
- Sensitivity of comorbidity network analysis.JAMIA open · 2020Article
- Interplay of Darwinian Selection, Lamarckian Induction and Microvesicle Transfer on Drug Resistance in Cancer.Scientific reports · 2019Article
- Too much medicine? Scientific and ethical issues from a comparison between two conflicting paradigms.BMC public health · 2019Article
- Radiomics and liquid biopsy in oncology: the holons of systems medicine.Insights into imaging · 2018Review
- New perspectives: systems medicine in cardiovascular disease.BMC systems biology · 2018Article
- Network spectra for drug-target identification in complex diseases: new guns against old foes.Applied network science · 2018Review
- Identification of the difference in the pathogenesis in heart failure arising from different etiologies using a microarray dataset.Clinics (Sao Paulo, Brazil) · 2017Article
- Conceptual Foundations of Systems Biology Explaining Complex Cardiac Diseases.Healthcare (Basel, Switzerland) · 2017Review
- Systems Medicine-Complexity Within, Simplicity Without.Journal of healthcare informatics research · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The exponential development of highly advanced scientific and medical research technologies throughout the past 30 years has arrived to the point where the high number of characterized molecular agents related to pathogenesis cannot be readily integrated or processed by conventional analytical approaches. Indeed, the realization that several moieties are signatures of disease has partly led to the increment of complex diseases being characterized. Scientists and clinicians can now investigate and analyse any individual dysregulations occurring within the genomic, transcriptomic, miRnomic, proteomic, and metabolomic levels thanks to currently available advanced technologies. However, there are drawbacks within this scientific brave new age in that only isolated molecular levels are individually investigated for their influence in affecting any particular health condition. Since their conception in 1992, systems biology/medicine focuses mainly on the perturbations of overall pathway kinetics for the consequent onset and/or deterioration of the investigated condition/s. Systems medicine approaches can therefore be employed for shedding light in multiple research scenarios, ultimately leading to the practical result of uncovering novel dynamic interaction networks that are critical for influencing the course of medical conditions. Consequently, systems medicine also serves to identify clinically important molecular targets for diagnostic and therapeutic measures against such a condition.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.