Evidence map›Paper›PMID 26357478›Full record

ArticleTherapeutics and clinical risk management2015

National consumption of opioid and nonopioid analgesics in Croatia: 2007-2013.

Darko Krnic, Andrea Anic-Matic, Svjetlana Dosenovic, Pero Draganic, Sasa Zezelic, Livia Puljak

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in Therapeutics and clinical risk management, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03161795 (Addressing the Risks of Long-Term Opioid Therapy in Chronic Noncancer Pain), which is not on this map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
2.6field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03161795 completednot on this mapstarted 2017, after this paper: background citation

Addressing the Risks of Long-Term Opioid Therapy in Chronic Noncancer Pain: A National, Multicenter, and Observational Cross-sectional Study in South Korea

Typeobservational_patient_registrySponsorSeoul National UniversityRan2017 to 2018Enrolled258ConditionsChronic Noncancer Pain, Opioid-Related Disorders
3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Darko KrnicAgency for Medicinal Products and Medical Devices, Zagreb, Croatia.
Andrea Anic-MaticLaboratory for Pain Research, School of Medicine, University of Split, Split, Croatia.
Svjetlana DosenovicLaboratory for Pain Research, School of Medicine, University of Split, Split, Croatia.
Pero DraganicAgency for Medicinal Products and Medical Devices, Zagreb, Croatia.
Sasa ZezelicAgency for Medicinal Products and Medical Devices, Zagreb, Croatia.
Livia PuljakLaboratory for Pain Research, School of Medicine, University of Split, Split, Croatia.
Agency for Medicinal Products and Medical Devices of Croatia · HRUniversity of Split · HR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe increased consumption of analgesics has been documented worldwide during the last 2 decades. The aim of the study was to examine the trends in opioid and nonopioid analgesic consumption in Croatia between 2007 and 2013.

methodsData on opioid consumption were extracted from the database of the national authority. All opioid and nonopioid analgesics were included in the analysis. Data were presented as defined daily doses per 1,000 inhabitants per day. Adequacy of opioid consumption was calculated using adequacy of consumption measure.

resultsDuring the examined 7-year period, the total consumption and total cost of all analgesics in Croatia showed continuous increase. In the M01A group (anti-inflammatory and antirheumatic products, nonsteroids), ibuprofen had an exponential increasing trend, and in 2011, it overtook diclofenac consumption. Ibuprofen and diclofenac had the highest consumption also in the M02A group of topical products for joint and muscular pain. Tramadol was by far the most consumed type of opioids (N02A group) and paracetamol in the group of other analgesics and antipyretics (N02B). The adequacy of consumption measure value was 0.19, indicating that Croatia is a country with a low opioid consumption.

conclusionBetween 2007 and 2013, both consumption of analgesics and their cost in Croatia had an increasing trend. Comparisons with data from other countries, based on the published literature, indicate that analgesic consumption in Croatia is still relatively low. Calculation of the adequacy of opioid consumption indicated that Croatia is a country with low opioid consumption. Further studies are necessary for establishing whether current analgesic consumption in Croatia corresponds to patient needs.

Indexed as

adequacyanalgesic agentsdrug utilizationpainprescription opioids

Identifiers

PMID26357478
PMCPMC4559243
OpenAlexW1433009074

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LicenceCC BY-NC
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.