ArticlePloS one2015
A Metagenomic Investigation of the Duodenal Microbiota Reveals Links with Obesity.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
66 citing papers in PubMed, 3 syntheses or guidelines pooled it, 128 citations in OpenAlex.
- Physical activity, sedentary behavior and microbiome: A systematic review and meta-analysis.Journal of science and medicine in sport · 2024Pooled it
- Systematic Review of the Effects of Exercise and Physical Activity on the Gut Microbiome of Older Adults.Nutrients · 2022Pooled it
- Pooled it
- Stunted childhood growth is associated with decompartmentalization of the gastrointestinal tract and overgrowth of oropharyngeal taxa.Proceedings of the National Academy of Sciences of the United States of America · 2018Trial
- Spatio-temporal dynamics of the human small intestinal microbiome and its response to a synbiotic.Gut microbesTrial
- Recent advances and clinical relevance of microbiome dynamics in health and disease.Gut microbes · 2026Review
- The duodenal microbiota is compartmentalized and clinically stable yet rapidly responsive to nutrient exposure.Gut microbes · 2026Article
- Advancements in the study of gut microbiome in disease diagnosis.Antonie van Leeuwenhoek · 2026Review
- Gut Microbiome in Obesity: A Narrative Review of Mechanisms, Interventions, and Future Directions.Probiotics and antimicrobial proteins · 2026Review
- Moderate increase in dietary fat induces alterations of microbiota and metabolome along the digestive tract prior to systemic metabolic changes: insights from a pig model.Gut microbes · 2025Article
- A Scoping Review on the Role of the Microbiome as a Factor in the Bidirectional Association Between Obesity and Depression.Current diabetes reports · 2025Article
- Double-Edged Sword: Urbanization and Response of Amniote Gut Microbiome in the Anthropocene.Microorganisms · 2025Review
- How to Study the Effects of Dietary Lipids on the Small Intestinal Microbiome? Methodological Design and Evaluation of the Human HealThy fAt, haPpy mIcRobiome (TAPIR) Proof-of-Concept Study.Current developments in nutrition · 2025Article
- Comparative analysis of amino acid auxotrophies and peptidase profiles in non-dysbiotic and dysbiotic small intestinal microbiomes.Computational and structural biotechnology journal · 2025Article
- Survey of gut microbial biogeography and their functional niche in the grow-finishing swine of ordinary feeding.Frontiers in microbiology · 2025Article
- Metagenomic analysis reveals the community composition of the microbiome in different segments of the digestive tract in donkeys and cows: implications for microbiome research.BMC microbiology · 2024Article
- Distinctive duodenal microbiomes and bile acid profiles in duodenal tumor patients revealed by prospective observational study.Scientific reports · 2024Observational
- Antibiotic Residues in UK Foods: Exploring the Exposure Pathways and Associated Health Risks.Toxics · 2024Article
- Probiotics and Fecal Microbiota Transplantation in Major Depression: Doxa or Episteme?Advances in experimental medicine and biology · 2024Review
- Dysbiosis and primary B-cell immunodeficiencies: current knowledge and future perspective.Immunologic research · 2023Review
6 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 6 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundFew studies have tested the small intestine microbiota in humans, where most nutrient digestion and absorption occur. Here, our objective was to examine the duodenal microbiota between obese and normal volunteers using metagenomic techniques. METHODOLOGY/PRINCIPAL
findingsWe tested duodenal samples from five obese and five normal volunteers using 16S rDNA V6 pyrosequencing and Illumina MiSeq deep sequencing. The predominant phyla of the duodenal microbiota were Firmicutes and Actinobacteria, whereas Bacteroidetes were absent. Obese individuals had a significant increase in anaerobic genera (p < 0.001) and a higher abundance of genes encoding Acyl-CoA dehydrogenase (p = 0.0018) compared to the control group. Obese individuals also had a reduced abundance of genes encoding sucrose phosphorylase (p = 0.015) and 1,4-alpha-glucan branching enzyme (p = 0.05). Normal weight people had significantly increased FabK (p = 0.027), and the glycerophospholipid metabolism pathway revealed the presence of phospholipase A1 only in the control group (p = 0.05). CONCLUSIONS/SIGNIFICANCE: The duodenal microbiota of obese individuals exhibit alterations in the fatty acid and sucrose breakdown pathways, probably induced by diet imbalance.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.