Evidence map›Paper›PMID 26356710›Full record

Observational studyMedicine2015

Different Risk of Common Gastrointestinal Disease Between Groups Undergoing Hemodialysis or Peritoneal Dialysis or With Non-End Stage Renal Disease: A Nationwide Population-Based Cohort Study.

Yi-Che Lee, Shih-Yuan Hung, Hsi-Hao Wang, Hao-Kuang Wang, Chi-Wei Lin, Min-Yu Chang, Li-Chun Ho, Yi-Ting Chen, Ching-Fang Wu, Ho-Ching Chen and 4 more

Open access · goldAbstract readObservational Study
In one paragraph

Observational study in Medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 1 pooled it
3.8field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 1 synthesis or guideline pooled it, 52 citations in OpenAlex.

  1. Pooled it
  2. Gastrointestinal disease in end-stage renal disease.World journal of nephrology · 2025
    Review
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Gastrointestinal Manifestations of Adult Cystinosis in Iran: A Descriptive Study.Medical journal of the Islamic Republic of Iran · 2022
    Article
  9. Article
  10. Review
  11. Bleeding risk of haemodialysis and peritoneal dialysis patients.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2021
    Article
  12. Observational
  13. Review
  14. Acute pancreatitis in children on chronic maintenance dialysis.Pediatric nephrology (Berlin, Germany) · 2019
    Review
  15. Male Patients on Peritoneal Dialysis Have a Higher Risk of Sleep Apnea.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2019
    Observational
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 1 institution in 1 country.

Yi-Che LeeFrom the Department of Internal Medicine (Y-CL, S-YH, H-HW, M-YC, L-CH, Y-TC, C-FW, H-CC), Department of Neurosurgery (H-KW), Department of Medical Education (CW-L), School of Medicine for International Students (S-YH), E-DA Hospital/ I-Shou University, Kaohsiung, Taiwan. Institute of Clinical Medicine (Y-CL, H-KW, L-CH, Y-YC, S-HL), Biostatistics Consulting Center (W-MW) College of Medicine, National Cheng Kung University, Tainan, Taiwan. Department of Internal Medicine (J-MS), Department of Pediatrics (Y-YC), National Cheng Kung University Hospital, Tainan, Taiwan.
Shih-Yuan Hung
Hsi-Hao Wang
Hao-Kuang Wang
Chi-Wei Lin
Min-Yu Chang
Li-Chun Ho
Yi-Ting Chen
Ching-Fang Wu
Ho-Ching Chen
Wei-Ming Wang
Junne-Ming Sung
Yuan-Yow Chiou
Sheng-Hsiang Lin
Directorate-General for Interpretation · BE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Peritoneal dialysis (PD) is one type of renal replacement therapy, but potential peritoneal damage and gastrointestinal (GI) tract adverse effects during long-term exposure to bio-incompatible dialysate remain a concern. Although GI disease frequently occurs in dialysis patients, whether the risk of GI diseases differs among PD and hemodialysis (HD) or non-uremic groups is still uncertain.In this retrospective cohort study, data were obtained from the National Health Insurance Research Database, which includes almost all dialysis patients in Taiwan. Between 2000 and 2009, a total of 1791 PD and 8955 HD incident patients were enrolled and matched for age and sex or for propensity score. In addition, a comparison cohort of 8955 non-uremic patients was also selected. Individuals were monitored for the occurrence of common GI diseases until 2010, and data were analyzed using several different models.Generally speaking, the results showed that the risk of gastroesophageal reflux, intestinal obstruction or adhesions, and abdominal hernia was significantly higher in the PD group, whereas the risk of peptic ulcer disease and lower GI diverticula and bleeding was significantly greater in the HD group. Meanwhile, the risk of mesenteric ischemia, liver cirrhosis, and acute pancreatitis was higher in dialysis patients, but was not significantly different between the PD and HD groups; moreover, the risk of appendicitis in the PD group appeared to be lower than that in the HD group.In conclusion, dialysis patients have a higher risk of most common GI diseases, and PD and HD modalities are associated with different GI diseases.

Indexed as

Gastrointestinal DiseasesRenal Insufficiency, ChronicAdultAgedCohort StudiesFemaleHumansMaleMiddle AgedOutcome Assessment, Health CareRenal DialysisRetrospective StudiesRisk AssessmentRisk FactorsTaiwanTime

Identifiers

PMID26356710
PMCPMC4616635
OpenAlexW2326966321

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.