Evidence map›Paper›PMID 26356581›Full record

ArticleEvidence-based complementary and alternative medicine : eCAM2015

Alkaloids in Erythrina by UPLC-ESI-MS and In Vivo Hypotensive Potential of Extractive Preparations.

Liara Merlugo, Marí C Santos, Liane S Sant'Anna, Everson W F Cordeiro, Luiz A C Batista, Silvia T S Miotto, Cássia V Garcia, Cleci M Moreira, Andreas S L Mendez

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Evidence-based complementary and alternative medicine : eCAM, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 9 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Liara MerlugoPrograma de Pós-graduação em Bioquímica, Universidade Federal do Pampa, BR 472 Km 585, Caixa Postal 118, 97508-000 Uruguaiana, RS, Brazil ; Laboratório de Desenvolvimento e Controle de Qualidade de Medicamentos, Universidade Federal do Pampa, BR 472 Km 585, Caixa Postal 118, 97508-000 Uruguaiana, RS, Brazil.
Marí C SantosLaboratório de Desenvolvimento e Controle de Qualidade de Medicamentos, Universidade Federal do Pampa, BR 472 Km 585, Caixa Postal 118, 97508-000 Uruguaiana, RS, Brazil.
Liane S Sant'AnnaPrograma de Pós-graduação em Bioquímica, Universidade Federal do Pampa, BR 472 Km 585, Caixa Postal 118, 97508-000 Uruguaiana, RS, Brazil ; Laboratório de Fisiologia Cardiovascular, Universidade Federal do Pampa, BR 472 Km 585, Caixa Postal 118, 97508-000 Uruguaiana, RS, Brazil.
Everson W F CordeiroLaboratório de Desenvolvimento e Controle de Qualidade de Medicamentos, Universidade Federal do Pampa, BR 472 Km 585, Caixa Postal 118, 97508-000 Uruguaiana, RS, Brazil.
Luiz A C BatistaLaboratório de Desenvolvimento e Controle de Qualidade de Medicamentos, Universidade Federal do Pampa, BR 472 Km 585, Caixa Postal 118, 97508-000 Uruguaiana, RS, Brazil.
Silvia T S MiottoDepartamento de Botânica, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.
Cássia V GarciaFaculdade de Farmácia, Universidade Federal do Rio Grande do Sul, Avenida Ipiranga 2752, 90610-000 Porto Alegre, RS, Brazil.
Cleci M MoreiraPrograma de Pós-graduação em Bioquímica, Universidade Federal do Pampa, BR 472 Km 585, Caixa Postal 118, 97508-000 Uruguaiana, RS, Brazil ; Laboratório de Fisiologia Cardiovascular, Universidade Federal do Pampa, BR 472 Km 585, Caixa Postal 118, 97508-000 Uruguaiana, RS, Brazil.
Andreas S L MendezPrograma de Pós-graduação em Bioquímica, Universidade Federal do Pampa, BR 472 Km 585, Caixa Postal 118, 97508-000 Uruguaiana, RS, Brazil ; Faculdade de Farmácia, Universidade Federal do Rio Grande do Sul, Avenida Ipiranga 2752, 90610-000 Porto Alegre, RS, Brazil.
Universidade Federal do Pampa · BRUniversidade Federal do Rio Grande do Sul · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Erythrina species are used in popular medicine as sedative, anxiolytic, anti-inflammatory, and antihypertensive. In this work, we investigated the chemical composition of extracts obtained from leaves of E. falcata and E. crista-galli. The hypotensive potential of E. falcata and the mechanism of action were also studied. The extracts were obtained by maceration and infusion. The total content of phenolic compounds and flavonoids was estimated by spectrophotometric methods. The chemical constituents were studied performing a chromatographic analysis by UPLC-ESI-MS. For in vivo protocols, blood pressure and heart rate were measured by the invasive hemodynamic monitoring method. Different concentrations of extracts and drugs such as L-NAME, losartan, hexamethonium, and propranolol were administrated i.v. The results of total phenolic contents for E. falcata and E. crista-galli were 1.3193-1.4989 mgGAE/mL for maceration and 0.8771-0.9506 mgGAE/mL for infusion. In total flavonoids, the content was 7.7829-8.1976 mg RE/g for maceration and 9.3471-10.4765 RE mg/g for infusion. The chemical composition was based on alkaloids, suggesting the presence of erythristemine, 11β-methoxyglucoerysodine, erysothiopine, 11β-hydroxyerysodine-glucose, and 11-hydroxyerysotinone-rhamnoside. A potent dose-dependent hypotensive effect was observed for E. falcata, which may be related to the route of β-adrenergic receptors.

Identifiers

PMID26356581
PMCPMC4556073
OpenAlexW1489313662

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.