ArticleDeutsches Arzteblatt international2015
The prevalence of celiac disease in children and adolescents in Germany.
Article in Deutsches Arzteblatt international, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
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Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 81 citations in OpenAlex.
- Mass Screening Strategies for Celiac Disease in Apparently Healthy Children and Adolescents: A Systematic Review.Medicina (Kaunas, Lithuania) · 2026Pooled it
- Integrated multiomics reveals stable microbe-metabolite relationships in pediatric celiac disease.Frontiers in microbiology · 2026Article
- Healthcare resource utilization and cost in pediatric celiac disease: A case-control study using German insurance data.Journal of pediatric gastroenterology and nutrition · 2026Article
- Prevalence and Clinical Symptoms of Wheat Allergy in Adults and Adolescents in Central Europe.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2025Article
- Celiac Disease-Narrative Review on Progress in Celiac Disease.Foods (Basel, Switzerland) · 2025Review
- [Celiac disease: an update].Innere Medizin (Heidelberg, Germany) · 2025Review
- Evaluation of the Frequency of HLA-DQ2/DQ8 Genes Among Patients with Celiac Disease and Those on a Gluten-Free Diet.Foods (Basel, Switzerland) · 2025Article
- Burden of coeliac disease in Germany: real-world insights from a large retrospective health insurance claims database analysis.Therapeutic advances in gastroenterology · 2025Article
- Review
- Home capillary sampling and screening for type 1 diabetes, celiac disease, and autoimmune thyroid disease in a Swedish general pediatric population: the TRIAD study.Frontiers in pediatrics · 2024Article
- Review
- Prevalence of autoantibodies in patients with juvenile idiopathic arthritis: results from the German inception cohort ICON-JIA.Pediatric rheumatology online journal · 2022Article
- Celiac disease in children: Increasing prevalence and changing clinical presentations.Clinical and experimental pediatrics · 2021Article
- Different Clinical Features of Celiac Disease in Children, Adolescents, and Adults; a Cross-sectional Study.Middle East journal of digestive diseases · 2021Article
- [Prevalence of an association between coeliac disease and vitiligo].Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete · 2019Article
- Diet and Functional Gastrointestinal Disorders in Children. Is the Focus on Food Exaggerated?Nutrients · 2019Article
- Changing Pattern of Childhood Celiac Disease Epidemiology: Contributing Factors.Frontiers in pediatrics · 2019Review
- Diagnosing Celiac Disease: Towards Wide-Scale Screening and Serology-Based Criteria?Gastroenterology research and practice · 2019Review
- Prevalence of celiac disease among school-age children in Çorum, Turkey.The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2018Article
- Diabetes in Childhood and Adolescence.Deutsches Arzteblatt international · 2018Review
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundUntreated celiac disease is associated with increased morbidity and mortality. Until now, no up-to-date figures have been available on the prevalence of celiac disease among children and adolescents in Germany, or on the percentage of undiagnosed cases.
methodsTo estimate the prevalence of celiac disease, serum samples obtained from 2003 to 2006 from participants in the German Health Interview and Examination Survey for Children and Adolescents (KiGGS) were studied for celiac disease-specific autoantibodies and total IgA.
resultsOf the 12 741 study participants aged 1 to 17 years (6546 boys, 6195 girls), 9 (0.07%) had a reported history of celiac disease. An elevated concentration of serum autoantibodies to tissue transglutaminase was found in 91 children with a normal IgA concentration and in 7 with IgA deficiency. The prevalence of undiagnosed celiac disease, based on positive autoantibody findings, was 0.8% (95% confidence interval 0.6-1.0%), and the overall prevalence of the disease was 0.9%. Seropositive children and adolescents had lower ferritin and red blood cell folate concentrations than seronegative ones; they also tended to be shorter and to weigh less as reflected by age- and sex-standardized z-scores.
conclusionThe 0.9% prevalence of celiac disease in Germany, as determined from a combination of serological findings and clinical histories, is similar to reported prevalences elsewhere in Europe and North America. Pediatricians, primary care physicians, internists, and other specialists should be aware of the broad spectrum of clinical manifestations of this disease. Children who have symptoms suggestive of celiac disease or belong to a group at risk for it should be tested for antibodies against tissue transglutaminase, as should symptomatic adults after the exclusion of other possible causes. It is not yet clear whether asymptomatic adults from high-risk groups should be tested.
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