ArticleNature communications2015
Identification of a plastidial phenylalanine exporter that influences flux distribution through the phenylalanine biosynthetic network.
Article in Nature communications, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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Who cites it
40 citing papers in PubMed, 97 citations in OpenAlex.
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- RETICULATA1 is a plastid-localized basic amino acid transporter.Nature plants · 2025Article
- Nature's laboratory: plant metabolic engineering methods using phenylpropanoids as a case study.Biotechnology for biofuels and bioproducts · 2025Review
- A Guide to Metabolic Network Modeling for Plant Biology.Plants (Basel, Switzerland) · 2025Review
- Floral volatile benzenoids/phenylpropanoids: biosynthetic pathway, regulation and ecological value.Horticulture research · 2024Article
- Expression of dehydroshikimate dehydratase in poplar induces transcriptional and metabolic changes in the phenylpropanoid pathway.Journal of experimental botany · 2024Article
- Research advances in regulation and genetic engineering of floral scents.Plant biotechnology (Tokyo, Japan) · 2024Article
- UMAMIT44 is a key player in glutamate export from Arabidopsis chloroplasts.The Plant cell · 2024Article
- The cytosolic aminotransferase VAS1 coordinates aromatic amino acid biosynthesis and metabolism.Science advances · 2024Article
- The Main Functions of Plastids.Methods in molecular biology (Clifton, N.J.) · 2024Review
- Chloroplast Auxin Efflux Mediated by ABCB28 and ABCB29 Fine-Tunes Salt and Drought Stress Responses inPlants (Basel, Switzerland) · 2023Article
- The Dynamic Change in Aromatic Compounds and Their Relationship withMetabolites · 2023Article
- Identification of region-specific amino acid signatures for doxorubicin-induced chemo brain.Amino acids · 2023Article
- Emission of floral volatiles is facilitated by cell-wall non-specific lipid transfer proteins.Nature communications · 2023Article
- Lignin engineering in forest trees: From gene discovery to field trials.Plant communications · 2022Review
- Comprehensive genomic characterization of cotton cationic amino acid transporter genes reveals that GhCAT10D regulates salt tolerance.BMC plant biology · 2022Article
- Comparative transcriptome analysis linked to key volatiles reveals molecular mechanisms of aroma compound biosynthesis in Prunus mume.BMC plant biology · 2022Article
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Authors and funding
14 authors at 1 institution in 1 country.
Funding
Abstract
In addition to proteins, L-phenylalanine is a versatile precursor for thousands of plant metabolites. Production of phenylalanine-derived compounds is a complex multi-compartmental process using phenylalanine synthesized predominantly in plastids as precursor. The transporter(s) exporting phenylalanine from plastids, however, remains unknown. Here, a gene encoding a Petunia hybrida plastidial cationic amino-acid transporter (PhpCAT) functioning in plastidial phenylalanine export is identified based on homology to an Escherichia coli phenylalanine transporter and co-expression with phenylalanine metabolic genes. Radiolabel transport assays show that PhpCAT exports all three aromatic amino acids. PhpCAT downregulation and overexpression result in decreased and increased levels, respectively, of phenylalanine-derived volatiles, as well as phenylalanine, tyrosine and their biosynthetic intermediates. Metabolic flux analysis reveals that flux through the plastidial phenylalanine biosynthetic pathway is reduced in PhpCAT RNAi lines, suggesting that the rate of phenylalanine export from plastids contributes to regulating flux through the aromatic amino-acid network.
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