Evidence map›Paper›PMID 26356042›Full record

ArticleNeurobiology of aging2015

Breadth and age-dependency of relations between cortical thickness and cognition.

Timothy A Salthouse, Christian Habeck, Qolamreza Razlighi, Daniel Barulli, Yunglin Gazes, Yaakov Stern

Abstract read
In one paragraph

Article in Neurobiology of aging, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed.

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  16. Assessing Flexibility of Solution Strategy: Strategy Shifting as a Measure of Cognitive Reserve.The journals of gerontology. Series B, Psychological sciences and social sciences · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Timothy A SalthouseDepartment of Psychology, University of Virginia, Charlottesville, VA, USA. Electronic address: salthouse@virginia.edu.
Christian HabeckCognitive Neuroscience Division, Department of Neurology, Taub Institute for Research on Alzheimer's Disease and The Aging Brain, Columbia University College of Physicians and Surgeons, New York, NY, USA.
Qolamreza RazlighiCognitive Neuroscience Division, Department of Neurology, Taub Institute for Research on Alzheimer's Disease and The Aging Brain, Columbia University College of Physicians and Surgeons, New York, NY, USA.
Daniel BarulliCognitive Neuroscience Division, Department of Neurology, Taub Institute for Research on Alzheimer's Disease and The Aging Brain, Columbia University College of Physicians and Surgeons, New York, NY, USA.
Yunglin GazesCognitive Neuroscience Division, Department of Neurology, Taub Institute for Research on Alzheimer's Disease and The Aging Brain, Columbia University College of Physicians and Surgeons, New York, NY, USA.
Yaakov SternCognitive Neuroscience Division, Department of Neurology, Taub Institute for Research on Alzheimer's Disease and The Aging Brain, Columbia University College of Physicians and Surgeons, New York, NY, USA.

Funding

Exploring Cognitive Aging Using Reference Ability Neural NetworksR01AG038465 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI HABECK, CHRISTIAN GEORG, STERN, YAAKOV · 2011 to 2025
$17.0M
Exploring Cognitive Aging Using Refernce Ability Neural NetworksRF1AG038465 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI HABECK, CHRISTIAN GEORG, STERN, YAAKOV · 2016 to 2018
$7.6M
Short-term cognitive change in adults from 18 to 80R37AG024270 · NIA · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI SALTHOUSE, TIMOTHY · 2005 to 2014
$4.4M
Analyzing age-related changes of brain activation in subjects native spaceK01AG044467 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI RAZLIGHI, QOLAMREZA RAY · 2013 to 2017
$636k
NIA NIH HHS AG038465NIA NIH HHS K01 AG044467NIA NIH HHS R01 AG038465NIA NIH HHS R37 AG024270NIA NIH HHS R37AG024270NIA NIH HHS RF1 AG038465
6 · The paper itself

Abstract

Recent advances in neuroimaging have identified a large number of neural measures that could be involved in age-related declines in cognitive functioning. A popular method of investigating neural-cognition relations has been to determine the brain regions in which a particular neural measure is associated with the level of specific cognitive measures. Although this procedure has been informative, it ignores the strong interrelations that typically exist among the measures in each modality. An alternative approach involves investigating the number and identity of distinct dimensions within the set of neural measures and within the set of cognitive measures before examining relations between the 2 types of measures. The procedure is illustrated with data from 297 adults between 20 and 79 years of age with cortical thickness in different brain regions as the neural measures and performance on 12 cognitive tests as the cognitive measures. The results revealed that most of the relations between cortical thickness and cognition occurred at a general level corresponding to variance shared among different brain regions and among different cognitive measures. In addition, the strength of the thickness-cognition relation was substantially reduced after controlling the variation in age, which suggests that at least some of the thickness-cognition relations in age-heterogeneous samples may be attributable to the influence of age on each type of measure.

Indexed as

AdultAgedAgingCerebral CortexCognitionFemaleHumansMaleMiddle AgedYoung AdultCognitive functioningLevel of analysisNeural correlates

Identifiers

PMID26356042
PMCPMC4609615

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.