ArticlePloS one2015
Neutrophil Responses to Sterile Implant Materials.
Open access · goldAbstract read
In one paragraph
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
59citing papers in PubMed, 1 pooled it
3.3field-weighted citation impact, top 7% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
59 citing papers in PubMed, 1 synthesis or guideline pooled it, 127 citations in OpenAlex.
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Corrections and comments
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Authors and funding
23 authors at 5 institutions in 1 country.
Siddharth JhunjhunwalaDavid H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts, 02139, United States of America; Department of Anesthesiology, Boston Children's Hospital, Boston, Massachusetts, 02115, United States of America.
Stephanie Aresta-DaSilvaDavid H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts, 02139, United States of America; Department of Anesthesiology, Boston Children's Hospital, Boston, Massachusetts, 02115, United States of America.
Katherine TangDavid H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts, 02139, United States of America; Department of Anesthesiology, Boston Children's Hospital, Boston, Massachusetts, 02115, United States of America.
David AlvarezDepartment of Microbiology and Immunobiology, Harvard Medical School, Boston, Massachusetts, 02115, United States of America.
Matthew J WebberDavid H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts, 02139, United States of America; Department of Anesthesiology, Boston Children's Hospital, Boston, Massachusetts, 02115, United States of America.
Benjamin C TangDavid H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts, 02139, United States of America; Department of Anesthesiology, Boston Children's Hospital, Boston, Massachusetts, 02115, United States of America.
Danya M LavinDavid H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts, 02139, United States of America; Department of Anesthesiology, Boston Children's Hospital, Boston, Massachusetts, 02115, United States of America.
Omid VeisehDavid H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts, 02139, United States of America; Department of Anesthesiology, Boston Children's Hospital, Boston, Massachusetts, 02115, United States of America.
Joshua C DoloffDavid H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts, 02139, United States of America; Department of Anesthesiology, Boston Children's Hospital, Boston, Massachusetts, 02115, United States of America.
Suman BoseDavid H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts, 02139, United States of America; Department of Anesthesiology, Boston Children's Hospital, Boston, Massachusetts, 02115, United States of America.
Arturo VegasDavid H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts, 02139, United States of America; Department of Anesthesiology, Boston Children's Hospital, Boston, Massachusetts, 02115, United States of America.
Minglin MaDavid H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts, 02139, United States of America; Department of Anesthesiology, Boston Children's Hospital, Boston, Massachusetts, 02115, United States of America.
Gaurav SahayDavid H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts, 02139, United States of America; Department of Anesthesiology, Boston Children's Hospital, Boston, Massachusetts, 02115, United States of America.
Alan ChiuDavid H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts, 02139, United States of America; Department of Anesthesiology, Boston Children's Hospital, Boston, Massachusetts, 02115, United States of America.
Andrew BaderDavid H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts, 02139, United States of America; Department of Anesthesiology, Boston Children's Hospital, Boston, Massachusetts, 02115, United States of America.
Erin LanganDavid H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts, 02139, United States of America; Department of Anesthesiology, Boston Children's Hospital, Boston, Massachusetts, 02115, United States of America.
Sean SiebertDavid H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts, 02139, United States of America; Department of Anesthesiology, Boston Children's Hospital, Boston, Massachusetts, 02115, United States of America.
Jie LiDavid H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts, 02139, United States of America; Department of Anesthesiology, Boston Children's Hospital, Boston, Massachusetts, 02115, United States of America.
Dale L GreinerDepartment of Molecular Medicine, Diabetes Center of Excellence, University of Massachusetts Medical School, Worcester, Massachusetts, 01605, United States of America.
Peter E NewburgerDepartment of Pediatrics, University of Massachusetts Medical School, Worcester, Massachusetts, 01605, United States of America; Department of Cancer Biology, University of Massachusetts Medical School, Worcester, Massachusetts, 01605, United States of America.
Ulrich H von AndrianDepartment of Microbiology and Immunobiology, Harvard Medical School, Boston, Massachusetts, 02115, United States of America; The Ragon Institute of MGH, MIT and Harvard, Cambridge, Massachusetts, 02139, United States of America.
Robert LangerDavid H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts, 02139, United States of America; Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, 02139, United States of America; Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, Massachusetts, 02139, United States of America; Harvard-MIT Division of Health Science and Technology, Massachusetts Institute of Technology, Cambridge, Massachusetts, 02139, United States of America; Department of Anesthesiology, Boston Children's Hospital, Boston, Massachusetts, 02115, United States of America.
Daniel G AndersonDavid H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts, 02139, United States of America; Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, 02139, United States of America; Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, Massachusetts, 02139, United States of America; Harvard-MIT Division of Health Science and Technology, Massachusetts Institute of Technology, Cambridge, Massachusetts, 02139, United States of America; Department of Anesthesiology, Boston Children's Hospital, Boston, Massachusetts, 02115, United States of America.
Boston Children's Hospital · USMassachusetts Institute of Technology · USHarvard University · USUniversity of Massachusetts Chan Medical School · USHarvard–MIT Division of Health Sciences and Technology · US
Funding
The Development of Clinical Grade, Targeted Magnetic NanoparticlesU54CA151884 · NCI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI LANGER, ROBERT SAMUEL · 2010 to 2014
$11.3MTetramer CoreU19AI095261 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI VON ANDRIAN, ULRICH H · 2011 to 2015
$10.8MTRANSFUSION BIOLOGY AND MEDICINET32HL066987 · NHLBI · CHILDREN'S HOSPITAL BOSTON · PI JOHN P MANIS · 2001 to 2026
$10.2MPHOTOPOLYMERIZATION FOR NONINVASIVE CARTILAGE TISSUER01DE013023 · NIDCR · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI LANGER, ROBERT SAMUEL · 1998 to 2019
$6.8MCONTROLLED RELEASE OF MACROMOLECULESR01EB000244 · NIBIB · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI LANGER, ROBERT SAMUEL, TRAVERSO, CARLO GIOVANNI · 2002 to 2021
$6.1MGeneration and Function of NK Cell MemoryR01AI111595 · NIAID · HARVARD MEDICAL SCHOOL · PI VON ANDRIAN, ULRICH H · 2013 to 2017
$4.1MControlled Release of MacromoleculesR37EB000244 · NIBIB · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI LANGER, ROBERT SAMUEL · 2008 to 2017
$3.9MHigh-Throughput Craniofacial tissue engineeringR01DE016516 · NIDCR · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI LANGER, ROBERT SAMUEL · 2005 to 2014
$3.8MUltrasound Polymeric Drug DeliveryR01EB000351 · NIBIB · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI LANGER, ROBERT SAMUEL · 2002 to 2013
$3.0MNCI NIH HHS CA151884NCI NIH HHS U54 CA151884NHLBI NIH HHS 5T32 HL066987NHLBI NIH HHS T32 HL066987NIAID NIH HHS P01AI111595NIAID NIH HHS R01 AI111595NIAID NIH HHS U19 AI095261NIAID NIH HHS U19AI095261NIBIB NIH HHS EB000244NIBIB NIH HHS EB000351NIBIB NIH HHS R01 EB000244NIBIB NIH HHS R01 EB000351NIBIB NIH HHS R37 EB000244NIDCR NIH HHS DE013023NIDCR NIH HHS R01 DE013023NIDCR NIH HHS R01 DE016516
Abstract
In vivo implantation of sterile materials and devices results in a foreign body immune response leading to fibrosis of implanted material. Neutrophils, one of the first immune cells to be recruited to implantation sites, have been suggested to contribute to the establishment of the inflammatory microenvironment that initiates the fibrotic response. However, the precise numbers and roles of neutrophils in response to implanted devices remains unclear. Using a mouse model of peritoneal microcapsule implantation, we show 30-500 fold increased neutrophil presence in the peritoneal exudates in response to implants. We demonstrate that these neutrophils secrete increased amounts of a variety of inflammatory cytokines and chemokines. Further, we observe that they participate in the foreign body response through the formation of neutrophil extracellular traps (NETs) on implant surfaces. Our results provide new insight into neutrophil function during a foreign body response to peritoneal implants which has implications for the development of biologically compatible medical devices.
Indexed as
AnimalsCytokinesExtracellular TrapsFibrosisInflammation MediatorsLeukocyte CountMiceModels, AnimalNeutrophil InfiltrationNeutrophilsPhagocytosisProstheses and ImplantsCytokinesInflammation Mediators
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.